Abstract
Alzheimer's disease (AD) places a profound global challenge, driven by its escalating prevalence and the multifaceted strain it places on individuals, families, and societies. Family caregivers (FCs), who are pivotal in supporting family members with AD, frequently endure substantial emotional, physical, and psychological demands. To better understand the determinants of family caregiving strain, this study employed machine learning (ML) to develop predictive models identifying factors that contribute to caregiver burden over time. Participants were evaluated across sociodemographic clinical, psychophysiological, and psychological domains at baseline (T1; N = 130), six months (T2; N = 114), and twelve months (T3; N = 92). Results revealed three distinct risk profiles, with the first focusing on T2 data, highlighting the importance of distress, forgiveness, age, and heart rate variability. The second profile integrated T1 and T2 data, emphasizing additional factors like family stress. The third profile combined T1 and T2 data with sociodemographic and clinical features, underscoring the importance of both assessment moments on distress at T2 and forgiveness at T1 and T2, as well as family stress at T1. By employing computational methods, this research uncovers nuanced patterns in caregiver burden that conventional statistical approaches might overlook. Key drivers include psychological factors (distress, forgiveness), physiological markers (heart rate variability), contextual stressors (familial dynamics, sociodemographic disparities). The insights revealed enable early identification of FCs at higher risk of burden, paving the way for personalized interventions. Such strategies are urgently needed as AD rates rise globally, underscoring the imperative to safeguard both patients and the caregivers who support them.

Abstract
The concept of data spaces has emerged as a structured, scalable solution to streamline and harmonize data sharing across established ecosystems. Simultaneously, the rise of AI services enhances the extraction of predictive insights, operational efficiency, and decision-making. Despite the potential of combining these two advancements, integration remains challenging: data spaces technology is still developing, and AI services require further refinement in areas like ML workflow orchestration and energy-efficient ML algorithms. In this paper, we introduce an integrated architectural framework, developed under the Green.Dat.AI project, that unifies the strengths of data spaces and AI to enable efficient, collaborative data sharing across sectors. A practical application is illustrated through a smart farming use case, showcasing how AI services within a data space can advance sustainable agricultural innovation. Integrating data spaces with AI services thus maximizes the value of decentralized data while enhancing efficiency through a powerful combination of data and AI capabilities.

Abstract
Breakthroughs in sequencing technologies led to an exponential growth of genomic data, providing novel biological insights and therapeutic applications. However, analyzing large amounts of sensitive data raises key data privacy concerns, specifically when the information is outsourced to untrusted third-party infrastructures for data storage and processing (e.g., cloud computing). We introduce Gyosa, a secure and privacy-preserving distributed genomic analysis solution. By leveraging trusted execution environments (TEEs), Gyosa allows users to confidentially delegate their GWAS analysis to untrusted infrastructures. Gyosa implements a computation partitioning scheme that reduces the computation done inside the TEEs while safeguarding the users' genomic data privacy. By integrating this security scheme in Glow, Gyosa provides a secure and distributed environment that facilitates diverse GWAS studies. The experimental evaluation validates the applicability and scalability of Gyosa, reinforcing its ability to provide enhanced security guarantees.

Abstract
High-performance computing is pivotal for processing large datasets and executing complex simulations, ensuring faster and more accurate results. Improving the performance of software and scientific workflows in such environments requires careful analysis of their computational behavior and energy consumption. Therefore, maximizing computational throughput in these environments, through adequate software configuration and resource allocation, is essential for improving performance. The work presented in this paper focuses on leveraging regression-based machine learning and decision trees to analyze and optimize resource allocation in high-performance computing environments based on application's performance and energy metrics. Applied to a bioinformatics case study, these models enable informed decision-making by selecting the appropriate computing resources to enhance the performance of a phylogenomics software. Our contribution is to better explore and understand the efficient resource management of supercomputers, namely Santos Dumont. We show that the predictions for application's execution time using the proposed method are accurate for various amounts of computing nodes, while energy consumption predictions are less precise. The application parameters most relevant for this work are identified and the relative importance of each application parameter to the accuracy of the prediction is analysed.

Abstract
Driven by the NIST's post-quantum standardization efforts and the selection of Kyber as a lattice-based Key-Encapsulation Mechanism (KEM), severalPasswordAuthenticated KeyExchange (PAKE) protocols have been recently proposed that leverage a KEM to create an efficient, easy-to-implement and secure PAKE. In two recent works, Beguinet et al. (ACNS 2023) and Pan and Zeng (ASIACRYPT 2023) proposed generic compilers that transform KEM into PAKE, relying on an Ideal Cipher (IC) defined over a group. However, although IC on a group is often used in cryptographic protocols, special care must be taken to instantiate such objects in practice, especially when a low-entropy key is used. To address this concern, Dos Santos et al. (EUROCRYPT 2023) proposed a relaxation of the ICmodel under the Universal Composability (UC) framework called Half-Ideal Cipher (HIC). They demonstrate how to construct a UC-secure PAKE protocol, EKE-KEM, from a KEM and a modified 2round Feistel construction called m2F. Remarkably, the m2F sidesteps the use of an IC over a group, and instead employs an IC defined over a fixed-length bitstring domain, which is easier to instantiate. In this paper, we introduce a novel PAKE protocol called CHIC that improves the communication and computation efficiency of EKE-KEM, by avoiding the HIC abstraction. Instead, we split the KEM public key in two parts and use the m2F directly, without further randomization. We provide a detailed proof of the security of CHIC and establish precise security requirements for the underlying KEM, including one-wayness and anonymity of ciphertexts, and uniformity of public keys. Our findings extend to general KEM-based EKE-style protocols and show that a passively secure KEM is not sufficient. In this respect, our results align with those of Pan and Zeng (ASIACRYPT 2023), but contradict the analyses of KEM-to-PAKE compilers by Beguinet et al. (ACNS 2023) and Dos Santos et al. (EUROCRYPT 2023). Finally, we provide an implementation of CHIC, highlighting its minimal overhead compared to the underlying KEM - Kyber. An interesting aspect of the implementation is that we reuse the rejection sampling procedure in Kyber reference code to address the challenge of hashing onto the public key space. As of now, to the best of our knowledge, CHIC stands as the most efficient PAKE protocol from black-box KEM that offers rigorously proven UC security.