Abstract

Depressive symptoms are common among older adults and can significantly impact their quality of life. Yet, many older adults face barriers to accessing psychological treatment. Internet-based cognitive behavioural therapy (iCBT) is a promising alternative to face-to-face treatments, but its feasibility among older adults is less researched.

Abstract

Abstract
The current surge in the development of web applications highlights the necessity of incorporating user-specific preferences into the design process. An innovative approach to improving these applications involves the analysis of interaction data recorded by browsers, such as the number of mouse clicks and keystrokes. The data thus obtained provides valuable insight into user behavior, enabling effective personalization of web applications. The WebTraceSense project proposes the development of a web platform designed to facilitate the customization of the visualization of interaction data from websites. The platform will include a dynamic visualization component, which will support the identification of user behaviors, and a DevOps cycle, which will help streamline software cycle processes. This article presents a case study for the examination of user interaction logs from a visual data analysis tool, utilizing the functionalities of the WebTraceSense platform to facilitate the identification of behavioral trace patterns.

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This research investigates the use of artificial intelligence algorithms to identify behavioural patterns in computer use, with the aim of detecting trends that help to flag cases of depression by analysing the human-computer interaction records of these users, thereby increasing the quality of the data for early detection of these situations. Following design science methodology, a case study will be conducted using an existing mental health screening questionnaire, integrating an artificial intelligence layer to map mouse and keyboard interactions, followed by machine learning analysis of the records. The results of the machine learning assisted questionnaires will be compared with the results of the questionnaires without the mapping. If there is a significant difference, this model could be useful for making predictions about emotional states, contributing to the field of artificial intelligence and helping to prevent depression, which is the focus of the research, although the aim is to look at mental health in a global way.

Abstract
Enhancing the reproducibility and comprehension of adaptive immune receptor repertoire sequencing (AIRR-seq) data analysis is critical for scientific progress. This study presents guidelines for reproducible AIRR-seq data analysis, and a collection of ready-to-use pipelines with comprehensive documentation. To this end, ten common pipelines were implemented using ViaFoundry, a user-friendly interface for pipeline management and automation. This is accompanied by versioned containers, documentation and archiving capabilities. The automation of pre-processing analysis steps and the ability to modify pipeline parameters according to specific research needs are emphasized. AIRR-seq data analysis is highly sensitive to varying parameters and setups; using the guidelines presented here, the ability to reproduce previously published results is demonstrated. This work promotes transparency, reproducibility, and collaboration in AIRR-seq data analysis, serving as a model for handling and documenting bioinformatics pipelines in other research domains.