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About

Daniel Vasconcelos is the Head of INESC TEC’s Technology Licensing Office (TLO), boosting the societal impact of the R&D results generated at the institution. Making a smart use of different types of Intellectual Property Rights, Daniel the development and commercialisation of deep tech-based products and services on ICT and medical technology fields. Open source compliance is also a key field. Additionally, he is European IP Helpdesk Ambassador for Portugal, member of renowned associations of technology transfer professionals as ASTP-Proton and I3PM. Daniel is invited professor at Faculdade de Engenharia da Universidade do Porto for medical technology development (Biodesign) and Economics and Management courses. He holds a PhD in Biomedical Sciences, a MSc in Bioengineering, and a MSc in Innovation Economics and Management, all from U.Porto.

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020
Publications

2021

Pneuma: entrepreneurial science in the fight against the COVID-19 pandemic - a tale of industrialisation and international cooperation

Authors
Mendonça, JM; Cruz, N; Vasconcelos, D; Sá-Couto, C; Moreira, AP; Costa, P; Mendonça, H; Pereira, A; Naimi, Z; Miranda, V;

Publication
Journal of Innovation Management

Abstract
When the COVID-19 pandemic hits Portugal in early March 2020, medical doctors, engineers and researchers, with the encouragement of the Northern Region Health Administration, teamed up to develop and build, locally and in a short time, a ventilator that might eventually be used in extreme emergency situations in the hospitals of northern Portugal. This letter tells you the story of Pneuma, a low-cost emergency ventilator designed and built under harsh isolation constraints, that gave birth to derivative designs in Brazil and Morocco, has been industrialized with 200 units being produced and is now looking forward to the certification as a medical device that will possibly support a go-to-market launch. Open intellectual property (IP), multidisciplinarity teamwork, fast prototyping and product engineering have shortened to a few months an otherwise quite longer idea-to-product route, clearly demonstrating that when scientific and engineering knowledge hold hands great challenges can be successfully faced.

2020

Osteoclasts degrade fibrinogen scaffolds and induce mesenchymal stem/stromal osteogenic differentiation

Authors
Almeida, AR; Bessa Goncalves, M; Vasconcelos, DM; Barbosa, MA; Santos, SG;

Publication
Journal of Biomedical Materials Research Part A

Abstract

2018

The use of chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing

Authors
Vasconcelos, DP; Costa, M; Neves, N; Teixeira, JH; Vasconcelos, DM; Santos, SG; Aguas, AP; Barbosa, MA; Barbosa, JN;

Publication
Journal of Biomedical Materials Research Part A

Abstract

2018

Profiling the circulating miRnome reveals a temporal regulation of the bone injury response

Authors
Silva, AM; Almeida, MI; Teixeira, JH; Ivan, C; Oliveira, J; Vasconcelos, D; Neves, N; Ribeiro Machado, C; Cunha, C; Barbosa, MA; Calin, GA; Santos, SG;

Publication
THERANOSTICS

Abstract
Bone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the plasma miRnome after bone injury and determine its biological implications. Methods: A rat model of femoral bone defect was used, and animals were evaluated at days 3 and 14 after injury. Non-operated (NO) and sham operated animals were used as controls. Blood and spleen were collected and peripheral blood mononuclear cells (PBMC) and plasma were separated. Plasma miRnome was determined by RT-qPCR array and bioinformatics Ingenuity pathway analysis (IPA) was performed. Proliferation of bone marrow mesenchymal stem/stromal cells (MSC) was evaluated by Ki67 staining and high-throughput cell imaging. Candidate miRNAs were evaluated in splenocytes by RT-qPCR, and proteins found in the IPA analysis were analysed in splenocytes and PBMC by Western blot. Results: Bone injury resulted in timely controlled changes to the miRNA expression profile in plasma. At day 3 there was a major down-regulation of miRNA levels, which was partially recovered by day 14 post-injury. Interestingly, bone injury led to a significant up-regulation of let-7a, let-7d and miR-21 in plasma and splenocytes at day 14 relative to day 3 after bone injury, but not in sham operated animals. IPA predicted that most miRNAs temporally affected were involved in cellular development, proliferation and movement. MSC proliferation was analysed and found significantly increased in response to plasma of animals days 3 and 14 post-injury, but not from NO animals. Moreover, IPA predicted that miRNA processing proteins Ago2 and Dicer were specifically inhibited at day 3 post-injury, with Ago2 becoming activated at day 14. Protein levels of Ago2 and Dicer in splenocytes were increased at day 14 relative to day 3 post-bone injury and NO animals, while in PBMC, levels were reduced at day 3 (albeit Dicer was not significant) and remained low at day 14. Ephrin receptor B6 followed the same tendency as Ago2 and Dicer, while Smad2/3 was significantly decreased in splenocytes from day 14 relative to NO and day 3 post-bone injury animals. Conclusion: Results show a systemic miRNA response to bone injury that is regulated in time and is related to inflammation resolution and the start of bone repair/regeneration, unravelling candidate miRNAs to be used as biomarkers in the monitoring of healthy bone healing and as therapeutic targets for the development of improved bone regeneration therapies.

2018

Interplay between sympathetic nervous system and inflammation in aseptic loosening of hip joint replacement

Authors
Ribeiro da Silva, M; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJ;

Publication
Scientific Reports

Abstract