Abstract
Background: ROP Plus Form is an eye disease that can lead to blindness, and diagnosing it requires medical experts to manually examine the retinal condition. This task is challenging due to its subjective nature and poor image quality. Therefore, developing automatic tools for Retinal Blood Vessel Segmentation in fundus images could assist healthcare experts in diagnosing, monitoring, and prognosing the disease. Objective: This study focuses on developing a novel pipeline for automatically segmenting retinal blood vessels. The main requirements are that it can correctly identify the blood vessels in fundus images and perform well on different systems used for newborn evaluation. Methods: The pipeline uses different methods, including CIELAB Enhancement, Background Normalization, BellShaped Gaussian Matched Filtering, Modified Top-Hat operation, and a combination of vesselness filtering composed of Frangi and Jerman Filters. The segmentation is done by determining a threshold using the Triangle Threshold algorithm. A novel filter is also proposed to remove the Optical Disc artifacts from the primary segmentation based on the Circular Hough Transform. The segmentation pipeline is combined with different pretrained Convolution Neural Network architectures to evaluate its automatic classification capabilities. Results: The pipeline was tested with newborn fundus images acquired with Clarity RetCam3 and Phoenix ICON systems. The results were compared against annotations from three ophthalmologic experts. Clarity RetCam3 images achieved an accuracy of 0.94, specificity of 0.95, and sensitivity of 0.81, while Phoenix ICON images achieved an accuracy of 0.94, specificity of 0.97, and sensitivity of 0.83. The pipeline was also tested for the DRIVE Database, achieving an accuracy of 0.95, specificity of 0.97, and sensitivity of 0.82. For the classification task, the best results were achieved with the DenseNet121 architecture with an accuracy of 0.946. Conclusion: The segmentation scores were auspicious and confirmed the clinical relevance of the proposed pipeline. It has also proven to have a good generalization performance, essential for easier clinic integration. Finally, preliminary results on using CNNs showed how our work can be used to develop fully automatic tools for diagnosing ROP Plus form disease.

Abstract
The first scientific observations with adaptive optics (AO) at W. M. Keck Observatory (WMKO) began in 1999. Through 2023, over 1200 refereed science papers have been published using data from the WMKO AO systems. The scientific competitiveness of AO at WMKO has been maintained through a continuous series of AO and instrument upgrades and additions. This tradition continues with AO being a centerpiece of WMKO's scientific strategic plan for 2035. We will provide an overview of the current and planned AO projects from the context of this strategic plan. The current projects include implementation of new real-time controllers, the KAPA laser tomography system and the HAKA high-order deformable mirror system, the development of multiple advanced wavefront sensing and control techniques, the ORCAS space-based guide star project, and three new AO science instruments. We will also summarize steps toward the future strategic directions which are centered on ground-layer, visible and high-contrast AO.

Abstract
Manufacturing industry is experiencing another revolution towards the digitalization of industrial processes. Different value chain actors must share specific and sensitive data according to business and data requirements. Digital architectures must ensure seamless and comprehensive communications between actors according to agreed-upon vocabularies. The digital representation of machines and other types of equipment, including crucial information about their static and dynamic operational data, is made possible by the ontological modelling of Asset Administration Shells (AAS), which is proposed in this paper as modular and semantically interoperable resources. These Cognitive Digital Twins are herein defined with de facto domain ontologies that model the semantics of the current operation, status and configurations of assets. This paper reports a proof-of-concept technical implementation that demonstrates an innovative digital architecture that connects and communicates active and modular Digital Twin of a machine in a bi-directional, connecting this asset to a digital manufacturing service provider.

Abstract
Early and accurate disease diagnosis is pivotal for effective phytosanitary management strategies in agriculture. Hyperspectral sensing has emerged as a promising tool for early disease detection, yet challenges remain in effectively harnessing its potential. This study compares parametric spectral Vegetation Indices (VIs) and a nonparametric Gaussian Process Classification based on an Automated Spectral Band Analysis Tool (GPC-BAT) for diagnosing plant bacterial diseases using hyperspectral data. The study conducted experiments on tomato plants in controlled conditions and kiwi plants in field settings to assess the performance of VIs and GPC-BAT. In the tomato experiment, the modeling processes were applied to classify the spectral data measured on the healthy class of plants (sprayed with water only) and discriminate them from the data captured on plants inoculated with the two bacterial suspensions (108 CFU mL-1). In the kiwi experiment, the standard modeling results of the spectral data collected on nonsymptomatic plants were compared to the ones obtained using symptomatic plants' spectral data. VIs, known for their simplicity in extracting biophysical information, successfully distinguished healthy and diseased tissues in both plant species. The overall accuracy achieved was 63% and 71% for tomato and kiwi, respectively. Limitations were observed, particularly in differentiating specific disease infections accurately. On the other hand, GPC-BAT, after feature reduction, showcased enhanced accuracy in identifying healthy and diseased tissues. The overall accuracy ranged from 70% to 75% in the tomato and kiwi case studies. Despite its effectiveness, the model faced challenges in accurately predicting certain disease infections, especially in the early stages. Comparative analysis revealed commonalities and differences in the spectral bands identified by both approaches, with overlaps in critical regions across plant species. Notably, these spectral regions corresponded to the absorption regions of various photosynthetic pigments and structural components affected by bacterial infections in plant leaves. The study underscores the potential of hyperspectral sensing in disease diagnosis and highlights the strengths and limitations of VIs and GPC-BAT. The identified spectral features hold biological significance, suggesting correlations between bacterial infections and alterations in plant pigments and structural components. Future research avenues could focus on refining these approaches for improved accuracy in diagnosing diverse plant-pathogen interactions, thereby aiding disease diagnosis. Specifically, efforts could be directed towards adapting these methodologies for early detection, even before symptom manifestation, to better manage agricultural diseases.

Abstract

Abstract
This study focuses on the task of developing automated models for complex aerobatic aircraft maneuvers. The approach employed here utilizes Behavioral Cloning, a technique in which human pilots supply a series of sample maneuvers. These maneuvers serve as training data for a Machine Learning algorithm, enabling the system to generate control models for each maneuver. The optimal instances for each maneuver were chosen based on a set of objective evaluation criteria. By utilizing these selected sets of examples, resilient models were developed, capable of reproducing the maneuvers performed by the human pilots who supplied the examples. In certain instances, these models even exhibited superior performance compared to the pilots themselves, a phenomenon referred to as the clean-up effect. We also explore the application of transfer learning to adapt the developed controllers to various airplane models, revealing compelling evidence that transfer learning is effective for refining them for targeted aircraft. A comprehensive set of intricate maneuvers was executed through a meta -controller capable of orchestrating the fundamental maneuvers acquired through imitation. This undertaking yielded promising outcomes, demonstrating the proficiency of several Machine Learning models in successfully executing highly intricate aircraft maneuvers.