Abstract
We present DIO, a generic tool for observing inefficient and erroneous I/O interactions between applications and in-kernel storage backends that lead to performance, dependability, and correctness issues. DIO eases the analysis and enables near real-time visualization of complex I/O patterns for data-intensive applications generating millions of storage requests. This is achieved by non-intrusively intercepting system calls, enriching collected data with relevant context, and providing timely analysis and visualization for traced events. We demonstrate its usefulness by analyzing four production-level applications. Results show that DIO enables diagnosing inefficient I/O patterns that lead to poor application performance, unexpected and redundant I/O calls caused by high-level libraries, resource contention in multithreaded I/O that leads to high tail latency, and erroneous file accesses that cause data loss. Moreover, through a detailed evaluation, we show that, when comparing DIO's inline diagnosis pipeline with a similar state-of-the-art solution, our system captures up to 28x more events while keeping tracing performance overhead between 14% and 51%.

Abstract
Service-based architecture is an approach that emerged to overcome software development challenges such as difficulty to scale, low productivity, and strong dependence between elements. Microservice, an architectural style that follows this approach, offers advantages such as scalability, agility, resilience, and reuse. This architectural style has been well accepted and used in industry and has been the target of several academic studies. However, analyzing the state-of-the-art and -practice, we can notice a fuzzy limit when trying to classify and characterize the architecture of service-based systems. Furthermore, it is possible to realize that it is difficult to analyze the trade-offs to make decisions regarding the design and evolution of this kind of system. Some concrete examples of these decisions are related to how big the services should be, how they communicate, and how the data should be divided/shared. Based on this context, we developed the CharM, a model for characterizing the architecture of service-based systems that adopts microservices guidelines. To achieve this goal, we followed the guidelines of the Design Science Research in five iterations, composed of an ad-hoc literature review, discussions with experts, two case studies, and a survey. As a contribution, the CharM is an easily understandable model that helps professionals with different profiles to understand, document, and maintain the architecture of service-based systems.& COPY; 2023 Elsevier Inc. All rights reserved.

Abstract

Abstract
IntroductionHereditary transthyretin amyloidosis (ATTRv amyloidosis) is a rare neurological hereditary disease clinically characterized as severe, progressive, and life-threatening while the age of onset represents the moment in time when the first symptoms are felt. In this study, we present and discuss our results on the study, development, and evaluation of an approach that allows for time-to-event prediction of the age of onset, while focusing on genealogical feature construction. Materials and methodsThis research was triggered by the need to answer the medical problem of when will an asymptomatic ATTRv patient show symptoms of the disease. To do so, we defined and studied the impact of 77 features (ranging from demographic and genealogical to familial disease history) we studied and compared a pool of prediction algorithms, namely, linear regression (LR), elastic net (EN), lasso (LA), ridge (RI), support vector machines (SV), decision tree (DT), random forest (RF), and XGboost (XG), both in a classification as well as a regression setting; we assembled a baseline (BL) which corresponds to the current medical knowledge of the disease; we studied the problem of predicting the age of onset of ATTRv patients; we assessed the viability of predicting age of onset on short term horizons, with a classification framing, on localized sets of patients (currently symptomatic and asymptomatic carriers, with and without genealogical information); and we compared the results with an out-of-bag evaluation set and assembled in a different time-frame than the original data in order to account for data leakage. ResultsCurrently, we observe that our approach outperforms the BL model, which follows a set of clinical heuristics and represents current medical practice. Overall, our results show the supremacy of SV and XG for both the prediction tasks although impacted by data characteristics, namely, the existence of missing values, complex data, and small-sized available inputs. DiscussionWith this study, we defined a predictive model approach capable to be well-understood by medical professionals, compared with the current practice, namely, the baseline approach (BL), and successfully showed the improvement achieved to the current medical knowledge.

Abstract
This work presents a novel methodology for the quality assessment of material extrusion parts through AI-based Computer Vision. To this end, different techniques are integrated using inspection methods that are applied to other areas in additive manufacturing field. The system is divided into four main points: (1) pre-processing, (2) color analysis, (3) shape analysis, and (4) defect location. The color analysis is performed in CIELAB color space, and the color distance between the part under analysis and the reference surface is calculated using the color difference formula CIE2000. The shape analysis consists of the binarization of the image using the Canny edge detector. Then, the Hu moments are calculated for images from the part under analysis and the results are compared with those from the reference part. To locate defects, the image of the part to be analyzed is first processed with a median filter, and both the original and filtered image are subtracted. Then, the resulting image is binarized, and the defects are located through a blob detector. In the training phase, a subset of parts was used to evaluate the performance of different methods and to set the values of parameters. Later, in a testing and validation phase, the performance of the system was evaluated using a different set of parts. The results show that the proposed system is able to classify parts produced by additive manufacturing, with an overall accuracy of 86.5%, and to locate defects on their surfaces in a more effective manner.

Abstract
Climate change will increase the frequency of drought, heat waves, and wildfires. We intended to analyse how fire recurrence and/or induced water stress can affect seed germination and root cell division in Pinus pinaster Aiton. Seeds from stands with no prior fire history and from post-fire regeneration (in areas burnt once, twice, and thrice) in northern Portugal were germinated in distilled water (control) and polyethylene glycol (PEG) to simulate water stress for four weeks, followed by a recovery period. Roots were analysed cytogenetically. The germination index of the Pinus pinaster seeds was not statistically influenced by the induction of osmotic stress, nor by the fire recurrence of the stands. The mean germination time (MGT) was 10-29 days and 1-36 days for the stress and recovery periods, respectively, and increased with PEG concentration. The 20% PEG treatment inhibited root growth after germination. The 10% PEG treatment induced a high frequency of cytogenetic anomalies, mostly in the sites which experienced fire exposure. While fire recurrence did not affect the germination rate, it seemed to reduce the water stress response, negatively impacting cell division and impair root growth.