Abstract
eHealth is expected to integrate a comprehensive set of patient data sources into a coherent continuum, but implementations vary and Portugal is still lacking on electronic patient data sharing. In this work, we present a clinical information hub to aggregate multi-institution patient data and bridge the information silos. This integration platform enables a coherent object model, services-oriented applications development and a trust framework. It has been instantiated in the Rede Telematica de Sa de (www.RTSaude.org) to support a regional Electronic Health Record approach, fed dynamically from production systems at eight partner institutions, providing access to more than 11,000,000 care episodes, relating to over 350,000 citizens. The network has obtained the necessary clearance from the Portuguese data protection agency.

Abstract

Abstract
A Biased Random Key Genetic Algorithm (BRKGA) is proposed to find solutions for the unit commitment problem. In this problem, one wishes to schedule energy production on a given set of thermal generation units in order to meet energy demands at minimum cost, while satisfying a set of technological and spinning reserve constraints. In the BRKGA, solutions are encoded by using random keys, which are represented as vectors of real numbers in the interval [0, 1]. The GA proposed is a variant of the random key genetic algorithm, since bias is introduced in the parent selection procedure, as well as in the crossover strategy. Tests have been performed on benchmark large-scale power systems of up to 100 units for a 24 hours period. The results obtained have shown the proposed methodology to be an effective and efficient tool for finding solutions to large-scale unit commitment problems. Furthermore, from the comparisons made it can be concluded that the results produced improve upon some of the best known solutions.

Abstract
Low-cost short read sequencing technology has revolutionized genomics, though it is only just becoming practical for the high-quality de novo assembly of a novel large genome. We describe the Assemblathon 1 competition, which aimed to comprehensively assess the state of the art in de novo assembly methods when applied to current sequencing technologies. In a collaborative effort, teams were asked to assemble a simulated Illumina HiSeq data set of an unknown, simulated diploid genome. A total of 41 assemblies from 17 different groups were received. Novel haplotype aware assessments of coverage, contiguity, structure, base calling, and copy number were made. We establish that within this benchmark: ( 1) It is possible to assemble the genome to a high level of coverage and accuracy, and that ( 2) large differences exist between the assemblies, suggesting room for further improvements in current methods. The simulated benchmark, including the correct answer, the assemblies, and the code that was used to evaluate the assemblies is now public and freely available from http://www.assemblathon.org/.

Abstract
Optical fibre sensors for Hydrogen detection at low concentrations has become a growing research area using Palladium as an active medium. Palladium is widely used in hydrogen sensing as it show a high and selective affinity for hydrogen. This metal is capable to absorb hydrogen up to 900 times its own volume which permits that during the expansion mechanical forces are applied in the fibre modifying the optical response. Several optical fibre hydrogen sensor heads coated with Palladium are presented and compared using different working principles: interferometric, intensity and fiber grating-based sensors. These principles were applied in Fabry-Perot cavities, fibre Bragg gratings written in fibre SMF28 with etching in the cladding, multimode interferometers and fibre end micro-mirrors. Palladium thin film coatings over the fibre surface and with thicknesses from 10nm to 350nm were produced by using the sputtering RF technique. These studies were performed in a Hydrogen/Nitrogen atmosphere with Hydrogen concentrations from 0% to 4% (lower limit explosion). The Bragg grating inscribed in a fibre with reduced cladding diameter appears to be one of the best approaches for a fibre optic sensing head for Hydrogen detection. Future work will continue the investigation of other fibre optic structures with Hydrogen sensing capabilities and their application in specific field situations will be assessed.

Abstract
In this paper we describe a parameter optimization approach to a simulation algorithm of a mixer-settler system in the transient state. The model we are using for the shallow-layer settler, in a mixer-settler system, is able to describe the hydrodynamic phenomena of the transient state of a liquid liquid system. Its mathematical model includes parameters of the drop transport process as well as of the drop drop and drop-interface coalescence with the active interface. The most adequate values of these parameters are unknown. In order to tune the model parameters we have Linked the mixer-settler simulation algorithm to an optimization procedure. We have used the Hooke-Jeeves optimization algorithm to fit these parameters to given experimental results.