Abstract

Abstract
In the present study the strategies of innovation, risk and proactiveness in micro and small businesses comparing their results between family and non- family firms were studied. Although it is common to find in the literature a trend of better performance of family businesses, this work is counteracted this trend. Not to the particular performance level, but the strategies presented, whose adoption leads to better performance. The study was carried out in the Vale do Sousa region and industrial and construction companies were considered. In terms of results, the sample allows us to conclude by 47 % of family businesses. Comparing the family business groups and unfamiliar, it was found that there were no differences in terms of innovation strategies and risks, however, the non- family businesses have become more proactive. In line with these results also found that it is not possible to distinguish between family and non- family firms in terms of entrepreneurship.

Abstract
We report on the use of second-order Raman amplification to assist a phase-sensitive optical time domain reflectometer (phi OTDR) used for vibration measurements over very long distances. The sensor was able to measure vibrations of up to 380 Hz (limit set by the time of flight of light pulses) in a distance of 125 km with a resolution of 10 m and no post-processing. Balanced detection is used to reduce the relative intensity noise. A comparison with a sensor using first-order Raman amplification under similar conditions is presented and a clear improvement of performance is demonstrated.

Abstract
The so called 'Soft Skills' (SSs) are the set of non-technical skills that enable a given individual to interact effectively and harmoniously with other people. These skills are also interesting for the promotion of deep knowledge and to foster academic success. The case study analyses the very special 'Projeto FEUP' course that promotes SSs across all engineering programmes in the Faculty of Engineering of the University of Porto (FEUP), in Portugal. This is done right after the arrival of students at the institution by means of producing several communicational items over an adequate technical work. The study involved 781 students. The presented results hint that Soft Skills are, in fact, improved after half-semester but this is not the sole product of the mentioned course.

Abstract
RNA-sequencing (RNA-Seq) has become the technology of choice for whole-transcriptome profiling. However, processing the millions of sequence reads generated requires considerable bioinformatics skills and computational resources. At each step of the processing pipeline many tools are available, each with specific advantages and disadvantages. While using a specific combination of tools might be desirable, integrating the different tools can be time consuming, often due to specificities in the formats of input/output files required by the different programs. Here we present iRAP, an integrated RNA-seq analysis pipeline that allows the user to select and apply their preferred combination of existing tools for mapping reads, quantifying expression, testing for differential expression. iRAP also includes multiple tools for gene set enrichment analysis and generates web browsable reports of the results obtained in the different stages of the pipeline. Depending upon the application, iRAP can be used to quantify expression at the gene, exon or transcript level. iRAP is aimed at a broad group of users with basic bioinformatics training and requires little experience with the command line. Despite this, it also provides more advanced users with the ability to customise the options used by their chosen tools.

Abstract
Laparoscopic surgery (LS) has revolutionized traditional surgical techniques introducing minimally invasive procedures for diagnosis and local therapies. LSs have undeniable advantages, such as small patient incisions, reduced postoperative pain and faster recovery. On the other hand, restricted vision of the anatomical target, difficult handling of the surgical instruments, restricted mobility inside the human body, need of dexterity to hand-eye coordination and inadequate and non-ergonomic surgical instruments may restrict LS only to more specialized surgeons. To overcome the referred limitations, this work presents a new robotic surgical handheld system - the EndoRobot. The EndoRobot was designed to be used in clinical practice or even as a surgical simulator. It integrates an electromechanical system with 3 degrees of freedom. Each degree can be manipulated independently and combined with different levels of sensitivity allowing fast and slow movements. As other features, the EndoRobot has battery power or external power supply, enables the use of bipolar radiofrequency to prevent bleeding while cutting and allows plug-and-play of the laparoscopic forceps for rapid exchange. As a surgical simulator, the system was also instrumented to measure and transmit, in real time, its position and orientation for a training software able to monitor and assist the trainee's surgical movements.