Abstract

Abstract
Microgrid, as an emerging small-scale power system comprising a range of power sources, power electronic interfaces, loads, storage units, and being able to supply remote areas or local communities, either can be operated in islanded or grid-connected mode. Based on this concept, this paper proposes the scalability assessment and day-ahead optimization, with time-varying load and time-of-use tariff data in 48 time-periods, for multiple microgrids applied in the accommodation area in a UK university, based on an existing microgrid test system currently under investigation in its Smart Grid Laboratory. Four different scenarios, including weekdays and weekends over two seasons (summer and winter), are analyzed to achieve the optimal scheduling of the microgrid technologies. In addition, a long-term planning assessment, on optimization over 20 years, is presented to discuss the influence of microgrids' power component depreciation and life span on total energy costs and savings.

Abstract
Dizajn distributivne mreže predstavlja jednu od strateških odluka u konkurenciji za kompanije visokog uticaja. Optimalna lokacija objekata u odnosu na kapacitet ponude i potražnje omogucuje visokom nivou usluga prisustvo na tržištu. U ovom radu predstavljen je metodološki okvir za projektovanje distributivnih mreža kombinovanjem primene tehnika klastera i matematickog programiranja. Predložena metodologija je testirana sa realnim podacima dobijenim od kompanije bezalkoholnih pica u Kolumbiji. Pristup razmatra tri glavne faze. U prvoj fazi, proces klasteriranja kupaca vrši se pomocu K-sredstava kako bi se dobila lokacija za potencijalne distributivne centre (DC). U drugoj fazi, model za dizajn distributivne mreže se vrši pomocu mešovitog programiranja celih brojeva (MPCB) razmatrajuci razlicite opcije za dodeljivanje DC-ma. U finalnoj fazi vrši se procena predložene metodologije u realnom slucaju. Kao rezultat, definisana je distributivna šema koja omogucava ulaz u nova tržišna podrucja sa efikasnom strategijom za prodiranje proizvoda u velike gradove kao što je Bogota u Kolumbiji.

Abstract
ABSTRACTTumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity. Using a novel transgenic steroidogenesis-reporter mouse line we identify and characterize de novo steroidogenic immune cells. Genetic ablation of T cell steroidogenesis restricts primary tumor growth and metastatic dissemination in mouse models. Steroidogenic T cells dysregulate anti-tumor immunity, and inhibition of the steroidogenesis pathway was sufficient to restore anti-tumor immunity. This study demonstrates T cell de novo steroidogenesis as a mechanism of anti-tumor immunosuppression and a potential druggable target.

Abstract
Higher education is a complex business including very different process. At its core are the teaching and research processes and along the edge of the business model are the administrative processes, targeted to the students and alumni. Some of these processes translate into services that must be available during the whole life of the users and the institutions. For example, a higher education institution is expected to issue diplomas during the whole lifetime of its former students. In this context, we've been working in order to use the current e-government infrastructure of electronic services as building blocks for some of the features of the higher education institution electronic services. This work proposes the adoption of a set of those services. We've concluded a successful testing stage and expect to deploy a full production system very soon.

Abstract
Portugal, as part of the European Union, has general legislation regarding accessibility and inclusion for general purposes, particularly for education. There are several international and national initiatives, including some projects. However, disabled and non-disabled people still do not share equal opportunities. In this project a proposal for a remote class system is presented, which includes sign language interpretation, targeted at those students who cannot be physically present in the classroom and/or need sign language interpretation. The system is based on audio and video communication between the classroom, the student and an interpreter, so that the student can access and understand the content of the class in real-time, as well as be able to interact with the professor and classmates. A prototype is being developed in conjunction with the Portugal Telecom Foundation, which should be a step forward to a new full-featured service targeted at educational institutions and disabled students. © Springer International Publishing AG, part of Springer Nature 2018.