Abstract
Purpose: BCCT.core (Breast Cancer Conservative Treatment. cosmetic results) is a software created for the objective evaluation of aesthetic result of breast cancer conservative treatment using a single patient frontal photography. The lack of volume information has been one criticism, as the use of 3D information might improve accuracy in aesthetic evaluation. In this study, we have evaluated the added value of 3D information to two methods of aesthetic evaluation: a panel of experts; and an augmented version of the computational model - BCCT.core3d. Material and methods: Within the scope of EU Seventh Framework Programme Project PICTURE, 2D and 3D images from 106 patients from three clinical centres were evaluated by a panel of 17 experts and the BCCT.core. Agreement between all methods was calculated using the kappa (K) and weighted kappa (wK) statistics. Results: Subjective agreement between 2D and 3D individual evaluation was fair to moderate. The agreement between the expert classification and the BCCT.core software with both 2D and 3D features was also fair to moderate. Conclusions: The inclusion of 3D images did not add significant information to the aesthetic evaluation either by the panel or the software. Evaluation of aesthetic outcome can be performed using of the BCCT.core software, with a single frontal image.

Abstract
The present paper proposes two hybrid genetic algorithms as decision-making techniques for operational level decisions in the Glass Container Industry (GCI). The proposed methods address a production scenario where one new furnace and the related machines must be added to the current industrial plant. The configurations for each machine connected in a furnace is a decision to be taken, which depends on demand forecasts for glass containers within a time horizon. It is a tactical and operational level decisions that must be efficiently made. A mathematical formulation is first presented to describe precisely the objective and constraints for such problem. The formulation will also allow solving the problem instances by applying an exact method. Next, a hybrid approach combining genetic algorithms with mathematical programming techniques, and a greedy filter heuristic is proposed to solve the same problem instances. The set of instances is generated with data provided by a GCI located in Portugal and Brazil. The results reported indicate that the hybrid genetic algorithms return solutions able to support the operational and tactical decisions.

Abstract
This paper offers a review of published conceptual and empirical studies indexed in the main academic search databases, covering literature on the internationalization of small and medium-sized firms. We analyzed a total of 554 papers covering the period between 1977 and 2014, and found the following general trends: empirical research focuses mainly on Europe and is characterized by a diversity that identifies 74 different topics. This study provides academics and practitioners with a clear perspective on future directions of SME internationalization and contributes to our understanding of the relevant research to date. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.

Abstract
The latest generation of high-contrast instruments dedicated to exoplanets and circumstellar disk imaging are equipped with extreme adaptive optics and coronagraphs to reach contrasts of up to 10 -4 at a few tenths of arcseconds in the near-infrared. The resulting image shows faint features, only revealed with this combination, such as the wind driven halo. The wind driven halo is due to the lag between the adaptive optics correction and the turbulence speed over the telescope pupil. However, we observe an asymmetry of this wind driven halo that was not expected when the instrument was designed. In this letter, we describe and demonstrate the physical origin of this asymmetry and support our explanation by simulating the asymmetry with an end-To-end approach. From this work, we find that the observed asymmetry is explained by the interference between the AO-lag error and scintillation effects, mainly originating from the fast jet stream layer located at about 12 km in altitude. Now identified and interpreted, this effect can be taken into account for further design of high-contrast imaging simulators, next generation or upgrade of high-contrast instruments, predictive control algorithms for adaptive optics, or image post-processing techniques.

Abstract
Demographic changes are leading to a growing older population (>65 years), with repercussions on age-related conditions. From a Computer Science perspective, this also means that there will soon be a significant number of users with changes in perceptual and motor skill capacities. The goal of this work is to develop an environment to support the preservation of memory and functional capacities of the elderly. Health professionals will be able to set up and personalize immersive and realistic scenarios with high ecological validity composed of visual, auditory, and physical stimuli. Patients will navigate through and interact with these scenarios and stimulate memory functions by later recalling distinct aspects of the different exercises of the tool. The long-term goal is to build a behavioral model of how older users interact with technology.

Abstract
Recent trends on microbiology point out the urge to develop optical micro-tools with multifunctionalities such as simultaneous manipulation and sensing. Considering that miniaturization has been recognized as one of the most important paradigms of emerging sensing biotechnologies, optical fiber tools, including Optical Fiber Tweezers (OFTs), are suitable candidates for developing multifunctional small sensors for Medicine and Biology. OFTs are flexible and versatile optotools based on fibers with one extremity patterned to form a micro-lens. These are able to focus laser beams and exert forces onto microparticles strong enough (piconewtons) to trap and manipulate them. In this paper, through an exploratory analysis of a 45 features set, including time and frequency-domain parameters of the back-scattered signal of particles trapped by a polymeric lens, we created a novel single feature able to differentiate synthetic particles (PMMA and Polystyrene) from living yeasts cells. This single statistical feature can be useful for the development of label-free hybrid optical fiber sensors with applications in infectious diseases detection or cells sorting. It can also contribute, by revealing the most significant information that can be extracted from the scattered signal, to the development of a simpler method for particles characterization (in terms of composition, heterogeneity degree) than existent technologies.