Abstract
The main objective of this work was to answer the question 'How are videogames implemented in healthcare organizations to be used as therapy instruments?'. This question emerged in the intersection of the recent increasing interest in the use of this type of technologies in therapy, with the importance of the implementation process for organizations to use a technology in its full potential. A multiple case study was performed, using three cases of implementations of Nintendo Wii console as a therapy instrument in rehabilitation clinics. The cases were used to compare the implementation of the same technology in organizations with the same core activity. The implementation processes were characterized and compared in light of the well-established literature about implementations of technologies, which led to a preliminary conceptual generalization of the implementation of videogames in healthcare organizations when they are intended to be used as therapy tools, highlighting the key characteristics of such projects. From this research it was possible to conclude that when adopting a console such as Nintendo Wii with rehabilitation purposes, the adoption decision seems to be predominantly informal; the stage of preparation of the implementation (when therapists conveniently prepare themselves to start using the console in their treatments) is quite important for the implementation process; the implementation of a technology such as Nintendo Wii occurs as a mutual adaptation process although with characteristics of a learning implementation, where adaptations occur mostly in the adopter; and, even though there may not be in place the best conditions to use the technology in its full potential, the efforts to routinize it may help overcoming the resistance to use it that results from those lack of conditions © 2017 IEEE.

Abstract
Unique Objects (UNOs) are relevant for real-world applications such as anti-counterfeiting systems. In this work, cork is demonstrated as a UNO, part of the Physical Unclonability and Disorder (PUD) system. An adequate measurement kit (illumination device) and recognition method are also devised and evaluated. Natural hills and valleys of the cork are enhanced using the illumination device and the overall robustness of the recognition application inherent to UNOs is presented. The lighting device is based on grazing light and the recognition task is based on a local feature detector and descriptor called ORB - Oriented FAST (Features from Accelerated Segment Test) and Rotated BRIEF (Binary Robust Independent Elementary Features). The performance evaluation utilizes a private cork database (1500 photos of 500 cork stoppers) and three public iris databases. In the tests carried out on the illumination device, the results clearly show the success of capturing stable/repeatable features needed for the recognition task in the cork database. This achievement is also reflected in the perfect recognition score achieved in the cork database, in the intra-distance measure mu(intra), which gives the notion of average noise between measures, and in the inter-distance mu(inter) which provides hints about the randomness/uniqueness of a cork. Regarding the recognition application, its effectiveness is further tested using the iris databases. Regardless of the fact that the recognition algorithm was not designed for the iris recognition problem, the results show that the proposed approach is capable of competing with the techniques found in the literature specially designed for iris recognition. Furthermore, the evaluation shows that the three requirements that constitute a UNO (Disorder, Operability, and Unclonability) are fulfilled, thus supporting the main assertion of this work: that cork is a UNO.

Abstract
Chaos Game Representation (CGR) of DNA sequences has been used for visual representation as well as alignment-free comparisons. CGR is considered to be of great value as the images obtained from parts of a genome present the same structure as those obtained for the whole genome. However, the robustness of the CGR method to compare DNA sequences obtained in a variety of scenarios is not yet fully demonstrated. This paper addresses this issue by presenting a method to evaluate the potential of CGR to distinguish various classes in a DNA dataset. Two indices are proposed for this purpose - a rejection rate and an overlapping rate. The method was applied to 4 datasets, with between 31 to 400 classes each. Nearly 430 million pairs of DNA sequences were compared using the CGR. © 2018, Springer Nature Switzerland AG.

Abstract
Doctoral programmes are facing several challenges in modern societies. The societal role of the University, funded by the state, requires it to: a) increase the offer and admission of third cycle students; b) to reach industry/companies expectations; c) to ensure reasonable employability prospects for the PhD candidates. With the current demography, most candidates can only find a job in industry/companies. Therefore, significant pressure is being put on doctoral programmes to include transferable skills in their curriculum. This paper presents a course "Fit for Industry?" aiming at filling this need. The course design methodology is presented in detail. It includes: a) the involvement of industry since its inception; b) the joint identification of a small number of key competencies to be addressed; c) the inclusion of assessment and feedback mechanisms in its design; d) an immersive and international dimension. It was found that the course had a profound impact on the candidates' perceptions of industry and valued by industry participants. Other stakeholders, such as PhD supervisors, also had a positive perception. The paper concludes with recommendations for those willing to replicate the course locally.

Abstract
The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch+RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed. These results suggest that Ch scaffolds embedded with RvD1 were able to lead to the formation of new bone with improvement of trabecular thickness. This study shows that the presence of RvD1 in the acute phase of the inflammatory response to the implanted biomaterial had a positive role in the subsequent bone tissue repair, thus demonstrating the importance of innovative approaches for the control of immune responses to biomedical implants in the design of advanced strategies for regenerative medicine. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1626-1633, 2018.

Abstract