Abstract
We propose a Relaxation Adaptive Memory Programming (RAMP) algorithm for the solution of the Single Source Capacitated Facility Location Problem (SSCFLP). This problem considers a set of possible locations for opening facilities and a set of clients whose demand must be satisfied. The objective is to minimize the cost of assigning the clients to the facilities, ensuring that all clients are served by only one facility without exceeding the capacity of the facilities. The RAMP framework efficiently explores the relation between the primal and the dual sides of combinatorial optimization problems. In our approach, the dual problem, obtained through a lagrangean relaxation, is solved by subgradient optimization. Computational experiments of the effectiveness of this approach are presented and discussed.

Abstract
This paper proposes a conventional approach for pulmonary nodule segmentation, that uses the Sliding Band Filter to estimate the center of the nodule, and consequently the filter's support points, matching the initial border coordinates. This preliminary segmentation is then refined to try to include mainly the nodular area, and no other regions (e.g. vessels and pleural wall). The algorithm was tested on 2653 nodules from the LIDC database and achieved a Dice score of 0.663, yielding similar results to the ground truth reference, and thus being a promising tool to promote early lung cancer screening and improve nodule characterization.

Abstract
Progress in the field of Natural Language Processing (NLP) has been closely followed by applications in the medical domain. Recent advancements in Neural Language Models (NLMs) have transformed the field and are currently motivating numerous works exploring their application in different domains. In this paper, we explore how NLMs can be used for Medical Entity Linking with the recently introduced MedMentions dataset, which presents two major challenges: (1) a large target ontology of over 2M concepts, and (2) low overlap between concepts in train, validation and test sets. We introduce a solution, MedLinker, that addresses these issues by leveraging specialized NLMs with Approximate Dictionary Matching, and show that it performs competitively on semantic type linking, while improving the state-of-the-art on the more fine-grained task of concept linking (+4 F1 on MedMentions main task).

Abstract
While service design has been accepted as a human-centered and cocreative approach to service innovation, its role in technology-driven contexts, specifically technology startups, has been largely unexplored. Previous research suggests that technology startups tend to focus on technical aspects of innovation, neglecting the value cocreation potential of service innovation that service design can facilitate. Focusing on value propositions as the main mechanisms of service innovation, this study explores how service design facilitates service innovation in technology startups. This longitudinal study examines the opportunities and challenges of introducing service design for the purpose of service innovation in five technology startups over a period of 11 months. Results reveal how service design facilitates the creation of new value propositions that expand the previous technology-driven focus towards a human-centered and cocreative one. Additionally, findings suggest that there are two levels of how service design becomes embedded in technology startups that are contingent on their life cycle stage. This contributes to the service innovation literature that views innovation as development of new value propositions and describes the key role of service design. The study also discusses managerial implications of the findings for technology startups and service designers and provides directions for future research.

Abstract
Invasive species present a global problem that requires better awareness from the general population. Serious games can serve as a tool for bringing attention to issues of this kind. People who are not informed cannot distinguish the invasive species apart from the ones native to a particular ecosystem. In this wok we present a serious game designed with the primary objective of informing people about the main characteristics of invasive plant species in Portugal, as well as showing proper ways of removing and disposing it, without allowing to spread throughout the local ecosystem. A game prototype was developed for mobile devices, since these are the most widely used platform, allowing the game's message to have a wider reach. Currently, the game has a single level focusing on a plant species, the water hyacinth, that thrive in rivers and lakes. User tests were performed to evaluate the prototype and to gather feedback and suggestions for future improvements. Results revealed a positive reception and an interest in further developments.

Abstract
Purpose This paper explores how service design can contribute to the evolution of health service systems, moving them toward people-centered, integrated and technology-enabled care; the paper develops a research agenda to leverage service design research for healthcare transformation. Design/methodology/approach This conceptual study starts by analyzing healthcare challenges in terms of demographic trends and economic constraints, along with the problems of lack of people-centricity, dispersion of care and slowness in incorporating emerging technologies. Then, it examines the theoretical underpinnings of service design to develop a framework for exploring how a human-centered, transformative and service systems approach can contribute to addressing healthcare challenges, with illustrative cases of service design research in healthcare being given. Findings The proposed framework explores how a human-centered service design approach can leverage the potential of technology and advance healthcare systems toward people-centered care; how a transformative service design approach can go beyond explanatory research of healthcare phenomena to develop innovative solutions for healthcare change and wellbeing; and how a service systems perspective can address the complexity of healthcare systems, hence moving toward integrated care. Originality/value This paper systematizes and develops a framework for how service design can contribute to healthcare transformation. It identifies key healthcare application areas for future service design research and pathways for advancing service design in healthcare by using new interdisciplinary bridges, methodological developments and theoretical foundations.