Abstract
Rapidly changing environments place different players at the vortex of the innovation process. Therefore, in the digital age, strong businesses are sometimes built on perceptions and on the approval of the community. The shift from linear value chains to ecosystems is likely to occur in 4.0 organizations adopting service or customer orientations, according to their participation in networked ecosystems. Moving from organization-centered innovation to ecosystem co-creation will approach individuals and institutions thus enhancing sustainable and smart product development along with trust. Embedded innovation is a self-sustained process in which firms and stakeholders interact in a common environment creating a common identity. Empirical results reinforce the role of open innovation strategies and the user community as pillars of sustainable innovation ecosystems. Policy actions need to reinforce these ecosystems as they will generate employment encompassing innovative and inclusive growth, fostering the resilience of societies and environmental sustainability. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Abstract
NADH:ubiquinone oxidoreductase, respiratory complex I, plays a central role in cellular energy metabolism. As a major source of reactive oxygen species (ROS) it affects ageing and mitochondrial dysfunction. The novel inhibitor NADH-OH specifically blocks NADH oxidation and ROS production by complex I in nanomolar concentrations. Attempts to elucidate its structure by NMR spectroscopy have failed. Here, by using X-ray crystallographic analysis, we report the structure of NADH-OH bound in the active site of a soluble fragment of complex I at 2.0 angstrom resolution. We have identified key amino acid residues that are specific and essential for binding NADH-OH. Furthermore, the structure sheds light on the specificity of NADH-OH towards the unique Rossmann-fold of complex I and indicates a regulatory role in mitochondrial ROS generation. In addition, NADH-OH acts as a lead-structure for the synthesis of a novel class of ROS suppressors.

Abstract

Abstract
The integration of the outbound and the inbound logistics of a company leads to a large transportation network, allowing to detect backhauling opportunities to increase the efficiency of the transportation. In collaborative networks, backhauling is used to find profitable services in the return trip to the depot and to reduce empty running of vehicles. This work investigates the vertical collaboration between a shipper and a carrier for the planning of integrated inbound and outbound transportation. Based on the hierarchical nature of the relation between the shipper and the carrier and their different goals, the problem is formulated as a bilevel Vehicle Routing Problem with Selective Backhauls (VRPSB). At the upper level, the shipper decides the minimum cost delivery routes and the set of incentives offered to the carrier to perform integrated routes. At the lower level, the carrier decides which incentives are accepted and on which routes the backhaul customers are visited. We devise a mathematical programming formulation for the bilevel VRPSB, where the routing and the pricing problems are optimized simultaneously, and propose an equivalent reformulation to reduce the problem to a single-level VRPSB. The impact of collaboration is evaluated against non-collaborative approaches and two different side payment schemes. The results suggest that our bilevel approach leads to solutions with higher synergy values than the approaches with side payments.

Abstract
Based on the perspective of information asymmetry theory and transaction cost theory, this paper discusses the effect of agricultural industrialization organizations on the quality of agricultural products. Through the survey of litchi growers in Guangdong Province and surrounding areas, it designs indicators suitable for measuring litchi quality from the two dimensions of safety and texture, uses factor analysis, correlation analysis, OLS model to test the hypothesis proposed herein. The results show that: the involvement of agricultural industrialization organizations has played an important role in improving litchi quality of growers. Enlightenment: unified management and unified standards through industrial organization forms such as enterprises, cooperatives, and associations are an important way to implement large-scale production of litchi, strengthen respective advantages, share risks, seek mutual benefit and win-win results. Government departments should play a leading and propaganda role, provide financial and technical support, improve the service system for the industrialization of the litchi industry, cultivate leading litchi enterprises, and accelerate the development of professional litchi cooperatives, associations and other intermediary organizations to make them become standardized and competitive main market players. © 2021 ACM.

Abstract
This article presents a contingency-based stochastic security-constrained unit commitment to address the integration of wind power producers to the joint energy and reserve markets. The model considers ancillary services as a solution to cope with the uncertainties of the problem. In this regard, a comprehensive model is considered that maintains the profit of supplementary services. The contingency ranking is a popular method for reducing the computation burden of the unit commitment problem, but performing the contingency analysis changes the high-impact events in previous ranking methods. This article employs an intelligent contingency ranking technique to address the above issue and to find the actual top-ranked outages based on the final solution. The proposed algorithm simultaneously clears the energy and reserve based on the mechanism of the day-ahead market. The main idea of this article is to develop a framework for considering the most effective outages in the presence of the uncertainty of wind power without a heavy computation burden. Also, energy storage systems are considered to evaluate the impact of the scheduling of storage under uncertainties. Also, an accelerated Benders decomposition technique is applied to solve the problem. Numerical results on a six-bus and the IEEE 118-bus test systems show the effectiveness of the proposed approach. Furthermore, it shows that utilizing both wind farms and storage devices will reduce the total operational cost of the system, while the intelligent contingency ranking analysis and enough reserves ensure the security of power supply.