Rui Camacho

Abstract

Abstract
Biological processes are mediated by protein-protein interactions (PPI) that have been studied using different methodologies, and organized as centralized repositories - PPI databases. The data stored in the different PPI databases only overlaps partially. Moreover, some of the repositories are dedicated to a species or subset of species, not all have the same functionalities, or store data in the same format, making comparisons between different databases difficult to perform. Therefore, here we present EvoPPI (http://evoppi.i3s.up.pt), an open source web application tool that allows users to compare the protein interactions reported in two different interactomes. When interactomes belong to different species, a versatile BLAST search approach is used to identify orthologous/paralogous genes, which to our knowledge is a unique feature of EvoPPI. © Springer Nature Switzerland AG 2019.

Abstract
Large corpus of scientific research papers have been available for a long time. However, most of those corpus store only the title and the abstract of the paper. For some domains this information may not be enough to achieve high performance in text mining tasks. This problem has been recently reduced by the growing availability of full text scientific research papers. A full text version provides more detailed information but, on the other hand, a large amount of data needs to be processed. A priori, it is difficult to know if the extra work of the full text analysis has a significant impact in the performance of text mining tasks, or if the effect depends on the scientific domain or the specific corpus under analysis. The goal of this paper is to show a framework for full text analysis, called LearnSec, which incorporates domain specific knowledge and information about the content of the document sections to improve the classification process with propositional and relational learning. To demonstrate the usefulness of the tool, we process a scientific corpus based on OSHUMED, generating an attribute/value dataset in Weka format and a First Order Logic dataset in Inductive Logic Programming (ILP) format. Results show a successful assessment of the framework.

Abstract

Abstract