Abstract
Objective: Murmurs are abnormal heart sounds, identified by experts through cardiac auscultation. The murmur grade, a quantitative measure of the murmur intensity, is strongly correlated with the patient's clinical condition. This work aims to estimate each patient's murmur grade (i.e., absent, soft, loud) from multiple auscultation location phonocardiograms (PCGs) of a large population of pediatric patients from a low-resource rural area. Methods: The Mel spectrogram representation of each PCG recording is given to an ensemble of 15 convolutional residual neural networks with channel-wise attention mechanisms to classify each PCG recording. The final murmur grade for each patient is derived based on the proposed decision rule and considering all estimated labels for available recordings. The proposed method is cross-validated on a dataset consisting of 3456 PCG recordings from 1007 patients using a stratified ten-fold cross-validation. Additionally, the method was tested on a hidden test set comprised of 1538 PCG recordings from 442 patients. Results: The overall cross-validation performances for patient-level murmur gradings are 86.3% and 81.6% in terms of the unweighted average of sensitivities and F1-scores, respectively. The sensitivities (and F1-scores) for absent, soft, and loud murmurs are 90.7% (93.6%), 75.8% (66.8%), and 92.3% (84.2%), respectively. On the test set, the algorithm achieves an unweighted average of sensitivities of 80.4% and an F1-score of 75.8%. Conclusions: This study provides a potential approach for algorithmic pre-screening in low-resource settings with relatively high expert screening costs. Significance: The proposed method represents a significant step beyond detection of murmurs, providing characterization of intensity, which may provide an enhanced classification of clinical outcomes.

Abstract
Physiological signals are often corrupted by noisy sources. Usually, artificial intelligence algorithms analyze the whole signal, regardless of its varying quality. Instead, experienced cardiologists search for a high-quality signal segment, where more accurate conclusions can be draw. We propose a methodology that simultaneously selects the optimal processing region of a physiological signal and determines its decoding into a state sequence of physiologically meaningful events. Our approach comprises two phases. First, the training of a neural network that then enables the estimation of the state probability distribution of a signal sample. Second, the use of the neural network output within an integer program. The latter models the problem of finding a time window by maximizing a likelihood function defined by the user. Our method was tested and validated in two types of signals, the phonocardiogram and the electrocardiogram. In phonocardiogram and electrocardiogram segmentation tasks, the system's sensitivity increased on average from 95.1% to 97.5% and from 78.9% to 83.8%, respectively, when compared to standard approaches found in the literature.

Abstract
The pericardium is a thin membrane sac that covers the heart. As such, the segmentation of the pericardium in computed tomography (CT) can have several clinical applications, namely as a preprocessing step for extraction of different clinical parameters. However, manual segmentation of the pericardium can be challenging, time-consuming and subject to observer variability, which has motivated the development of automatic pericardial segmentation methods. In this study, a method to automatically segment the pericardium in CT using a U-Net framework is proposed. Two datasets were used in this study: the publicly available Cardiac Fat dataset and a private dataset acquired at the hospital centre of Vila Nova de Gaia e Espinho (CHVNGE). The Cardiac Fat database was used for training with two different input sizes - 512 512 and 256 256. A superior performance was obtained with the 256 256 image size, with a mean Dice similarity score (DCS) of 0.871 ± 0.01 and 0.807 ± 0.06 on the Cardiac Fat test set and the CHVNGE dataset, respectively. Results show that reasonable performance can be achieved with a small number of patients for training and an off-the-shelf framework, with only a small decrease in performance in an external dataset. Nevertheless, additional data will increase the robustness of this approach for difficult cases and future approaches must focus on the integration of 3D information for a more accurate segmentation of the lower pericardium. © 2023, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

Abstract
Echocardiography is the most frequently used imaging modality in cardiology. However, its acquisition is affected by inter-observer variability and largely dependent on the operator's experience. In this context, artificial intelligence techniques could reduce these variabilities and provide a user independent system. In recent years, machine learning (ML) algorithms have been used in echocardiography to automate echocardiographic acquisition. This review focuses on the state-of-the-art studies that use ML to automate tasks regarding the acquisition of echocardiograms, including quality assessment (QA), recognition of cardiac views and assisted probe guidance during the scanning process. The results indicate that performance of automated acquisition was overall good, but most studies lack variability in their datasets. From our comprehensive review, we believe automated acquisition has the potential not only to improve accuracy of diagnosis, but also help novice operators build expertise and facilitate point of care healthcare in medically underserved areas.

Abstract
Gastric Cancer (GC) and Colorectal Cancer (CRC) are some of the most common cancers in the world. The most common diagnostic methods are upper endoscopy and biopsy. Possible expert distractions can lead to late diagnosis. GC is a less studied malignancy than CRC, leading to scarce public data that difficult the use of AI detection methods, unlike CRC where public data are available. Considering that CRC endoscopic images present some similarities with GC, a CRC Transfer Learning approach could be used to improve AI GC detectors. This paper evaluates a novel Transfer Learning approach for real-time GC detection, using a YOLOv4 model pre-trained on CRC detection. The results achieved are promising since GC detection improved relatively to the traditional Transfer Learning strategy.