2025
Authors
Caetano, E; MPM Oliveira, B; Correia, F; Torres, D; Poínhos, R;
Publication
Acta Portuguesa de Nutrição
Abstract
2025
Authors
Alexandre, MR; Poinhos, R; Oliveira, BMPM; Correia, F;
Publication
NUTRIENTS
Abstract
Background/Objectives: Obesity is a major contributor to cardiovascular disease, yet traditional risk assessment methods may overlook behavioral and circadian influences that modulate metabolic health. Chronotype, physical activity, sleep quality, eating speed, and breakfast habits have been increasingly associated with cardiometabolic outcomes. This study aims to evaluate the associations between these behavioral factors and both anthropometric and biochemical markers of cardiovascular risk among obese candidates for bariatric surgery. Methods: A cross-sectional study was conducted in a sample of 286 obese adults (78.3% females, mean 44.3 years, SD = 10.8, mean BMI = 42.5 kg/m2, SD = 6.2) followed at a central Portuguese hospital. Chronotype (reduced Morningness-Eveningness Questionnaire), sleep quality (Pittsburgh Sleep Quality Index), physical activity (Godin-Shephard Questionnaire), eating speed, and breakfast skipping were assessed. Cardiovascular risk markers included waist-to-hip ratio (WHR), waist-to-height ratio, A Body Shape Index (ABSI), Body Roundness Index, atherogenic index of plasma (AIP), triglyceride-glucose index (TyG), and homeostatic model assessment for insulin resistance (HOMA-IR). Results: Men exhibited significantly higher WHR, ABSI, HOMA-IR, TyG, and AIP. Eveningness was associated with higher insulin (r = -0.168, p = 0.006) and HOMA-IR (r = -0.156, p = 0.011). Poor sleep quality was associated with higher body fat mass (r = 0.151, p = 0.013), total cholesterol (r = 0.169, p = 0.005) and LDL cholesterol (r = 0.132, p = 0.030). Faster eating speed was associated with a higher waist circumference (r = 0.123, p = 0.038) and skeletal muscle mass (r = 0.160, p = 0.009). Conclusions: Male sex, evening chronotype, and poor sleep quality were associated with more adverse cardiometabolic profiles in individuals with severe obesity. These findings support the integration of behavioral and circadian factors into cardiovascular risk assessment strategies.
2023
Authors
Accinelli, E; Hernández-Lerma, O; Hervés-Beloso, C; Neme, A; Oliveira, BMPM; Pinto, AA; Yannacopoulos, AN;
Publication
Journal of Dynamics and Games
Abstract
2025
Authors
Kindlovits, R; Sousa, AC; Viana, JL; Milheiro, J; Oliveira, BMPM; Marques, F; Santos, A; Teixeira, VH;
Publication
NUTRIENTS
Abstract
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by hyperglycemia, which can affect metabolic, vascular, and hematological parameters. A low-carbohydrate, high-fat (LCHF) diet has been shown to improve glycemic control and blood pressure regulation. Exercise in hypoxia (EH) enhances insulin sensitivity, erythropoiesis, and angiogenesis. The combination of LCHF and EH may offer a promising strategy for managing T2DM and hypertension (HTN), although evidence remains limited. This study aimed to assess the effects of an eight-week normobaric EH intervention at 3000 m simulated altitude combined with an LCHF diet on hematological and lipid profiles, inflammation, and blood pressure in older patients with T2DM and HTN. Methods: Forty-two diabetic patients with HTN were randomly assigned to three groups: (1) control group (control diet + exercise in normoxia), (2) EH group (control diet + EH), and (3) intervention group (EH+LCHF) Baseline and eight-week measurements included systolic, diastolic, and mean blood pressure (SBP, DBP, MAP), hematological and lipid profiles, and inflammation biomarkers. Results: Blood pressure decreased after the intervention (p < 0.001), with no significant differences between groups (SBP: p = 0.151; DBP: p = 0.124; MAP: p = 0.18). No differences were observed in lipid profile or C-reactive protein levels (p > 0.05). Mean corpuscular hemoglobin (MCH) increased in the EH group (p = 0.027), while it decreased in the EH+LCHF group (p = 0.046). Conclusions: Adding hypoxia or restricting carbohydrates did not provide additional benefits on blood pressure in T2DM patients with HTN. Further elucidation of the mechanisms underlying hematological adaptations is imperative.
2024
Authors
Monteiro, M; Pereira, F; Gaspar, M; Jorge, I; Poínhos, R; Oliveira, BM; Rodrigues, S; Afonso, C;
Publication
Acta Portuguesa de Nutrição
Abstract
2024
Authors
Kindlovits, R; Sousa, AC; Viana, JL; Milheiro, J; Oliveira, BMPM; Marques, F; Santos, A; Teixeira, VH;
Publication
NUTRIENTS
Abstract
In the original publication [1], there was a minor error in Figure 1 and Table 6. Unfortunately, Figure 1 presented a smaller text size than appropriate, making it difficult for the reader, in addition to the abbreviation “FiO2” instead of “FiO2”. Then, in Table 6, the basal lactate values between the groups were corrected and the lactate peak values were included. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated. © 2024 by the authors.
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