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Abstract Predicting and controlling crowd dynamics in emergencies is one of the main objectives of simulated emergency exercises. However, during emergency exercises, there is often a lack of sense of danger by the actors involved and concerns about exposing real people to potentially dangerous environments. These problems impose limitations in running an emergency drill, harming the collection of valuable information for posterior analysis and decision-making. This work aims to mitigate these problems by using Agent Based Modelling (ABM) simulator to deepen the comprehension of human actions when exposed to a sudden variation in extensive crowded environmental conditions and how evacuation strategies affect evacuation performance. To assess the impact of the evacuation strategy employed, we propose a modified informed leader-flowing approach and compare it with common evacuation strategies in a simulated environment, replicating stadium benches with narrow corridors leading to different exit points. The objective is to determine the impact of each set of configurations and evacuation strategies and compare them against other established ones. Our experiments determined that agents following the crowd generally lead to a higher number of victims due to the rise of herding phenomena near the exits, which was significantly reduced when agents were guided towards the exit via knowing the exit beforehand or following leader agent with real-time information regarding exit location and exit current state, proving that relevant and controlled information in combination with Follow Leader strategies can be crucial in an emergency evacuation scenario with limited evacuation exit capabi and distribution.

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Biofeedback is a promising tool to complement conventional physical therapy by fostering active participation of neurologically impaired patients during treatment. This work aims at a user-centered design and usability assessment for different age groups of a novel wearable augmented reality application composed of a multimodal sensor network and corresponding control strategies for personalized biofeedback during gait training. The proposed solution includes wearable AR glasses that deliver visual cues controlled in real-time according to mediolateral center of mass position, sagittal ankle angle, or tibialis anterior muscle activity from inertial and EMG sensors. Control strategies include positive and negative reinforcement conditions and are based on the user's performance by comparing real-time sensor data with an automatically user-personalized threshold. The proposed solution allows ambulatory practice on daily scenarios, physiotherapists' involvement through a laptop screen, and contributes to further benchmark biofeedback regarding the type of sensor. Although old healthy adults with low academic degrees have a preference for guidance from an expert person, excellent usability scores (SUS scores: 81.25-96.87) were achieved with young and middle-aged healthy adults and one neurologically impaired patient.

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TPS621 Background: Breast cancer treatments often pose challenges in balancing efficacy with quality of life. The CINDERELLA Project pioneers an artificial intelligence (AI)-driven approach (CINDERELLA APP) for shared decision-making process, aiming to harmonise locoregional therapeutic interventions with breast cancer patients' expectations about aesthetic outcomes. The CINDERELLA clinical trial aims to establish a new standard in patient-centred care by bridging the gap between clinical treatment options and patient expectations through innovative technology. The trial focuses on evaluating the effectiveness of the CINDERELLA APP in improving patient satisfaction regarding locoregional treatment aesthetic outcomes, aligning patient expectations with real-world results, and assessing its impact on overall quality of life and psychological well-being. Methods: Trial design and statistical methods: This international multicentric interventional randomised controlled open-label clinical trial will recruit and randomise patients into two groups: one receiving standard treatment information and the other using the AI-powered CINDERELLA APP. The primary objective is to assess the levels of agreement among patients' expectations regarding the aesthetic outcome before and 12 months after locoregional treatment. The trial will also evaluate the aesthetic outcome level of agreement between the AI evaluation tool and self-evaluation. The impact of the intervention on aligning expectations with outcomes will be evaluated using the Wilcoxon signed-rank test. The improvement in classification of aesthetic results post-intervention will be measured by calculating the Weighted Cohen's kappa. Outcomes across different groups will be compared using statistical tests and bootstrap methods. CANKADO functions as the base system, allowing doctors to supervise APP content for patients and handle data gathering, while upholding principles of privacy, data security, and ethical AI practices. Intervention planned: Using the CINDERELLA APP, the patient will have access to supervised medical information approved by breast cancer experts, and the AI system will match patient's information to pictures showing the potential aesthetic outcome (spectrum of good-poor) according to different locoregional approach. Major eligibility criteria: Non-metastatic breast cancer patients eligible for either breast-conserving surgery or mastectomy with immediate reconstruction. Current enrollment: Recruitment is currently open at six study sites. The recruitment started on 8 August 2023, aiming to enroll at least 515 patients/arm. As of January 26, 2024, clinical study sites have successfully randomised 177 patients. Clinical trial information: NCT05196269 .

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