Abstract
The application of machine learning (ML) algorithms to electronic health records (EHR) data allows the achievement of data-driven insights on various clinical problems and the development of clinical decision support (CDS) systems to improve patient care. However, data governance and privacy barriers hinder the use of data from multiple sources, especially in the medical field due to the sensitivity of data. Federated learning (FL) is an attractive data privacy-preserving solution in this context by enabling the training of ML models with data from multiple sources without any data sharing, using distributed remotely hosted datasets. The Secur-e-Health project aims at developing a solution in terms of CDS tools encompassing FL predictive models and recommendation systems. This tool may be especially useful in Pediatrics due to the increasing demands on Pediatric services, and the current scarcity of ML applications in this field compared to adult care. Herein we provide a description of the technical solution proposed in this project for three specific pediatric clinical problems: childhood obesity management, pilonidal cyst post-surgical care and retinography imaging analysis.

Abstract
In this paper we explain how to compute gradients of functions of the form G = 1/2 Sigma(m)(i=1) (Ey(i) - C-i )(2), which often appear in the calibration of stochastic models, using automatic adjoint differentiation and parallelization. We expand on the work of Goloubentsev and Lakshtanov and give approaches that are faster and easier to implement. We also provide an implementation of our methods and apply the technique to calibrate European options.

Abstract
The Atacama desert is a region with exceptional conditions for solar power production. However, despite its relevance, the impact of climate change on this resource in this region has barely been studied. Here, we use regional climate models to explore how climate change will affect the photovoltaic solar power resource per square meter (PVres) in Atacama. Models project average reductions in PVres of 1.5% and 1.7% under an RCP8.5 scenario, respectively, for 2021-2040 and 2041-2060. Under RCP2.6 and the same periods, reductions range between 1.2% and 0.5%. Also, we study the contribution to future changes in PVres of the downwelling shortwave radiation, air temperature and wind velocity. We find that the contribution from changes in wind velocity is negligible. Future changes of downwelling shortwave radiation, under the RCP8.5 scenario, cause up to 87% of the decrease of PVres for 2021-2040 and 84% for 2041-2060. Rising temperatures due to climate change are responsible for drops in PVres ranging between 13%–19% under RCP2.6 and 14%–16% under RCP8.5. We conclude that climate change has the potential to impact the PVres in the Atacama region while retaining exceptional conditions for solar power production.

Abstract
This paper investigates voltage regulation in low voltage (LV) networks under different loading conditions of a supply network, with increased levels of distributed generation, and in particular with a diverse range of locational solar photovoltaic (PV) penetration. This topic has been researched extensively, with beneficial impacts expected up to a certain point when reverse power flows begin to negatively impact customers connected to the distribution system. In this paper, a voltage-based approach that utilizes novel voltage-based reliability indices is proposed to analyse the risk and reliability of the LV supply feeder, as well as its PV hosting capacity. The proposed indices are directly comparable to results from a probabilistic reliability assessment. The operation of the network is simulated for different PV scenarios to investigate the impacts of increased PV penetration, the location of PV on the feeder, and loading conditions of the MV supply network on the reliability results. It can be seen that all reliability indices improve with increased PV penetration levels when the supply network is heavily loaded and conversely deteriorate when the supply network is lightly loaded. Moreover, bus voltages improve when an on-load tap changer is fitted at the secondary trans-former which leads to better reliability performance as the occurrence and duration of low voltage violations are reduced in all PV scenarios. The approach in this paper is opposed to the conventional reliability assessment, which considers sustained interruptions to customers caused by failure of network components, and thus contributes to a comprehensive analysis of quality of service by considering transient events (i.e., voltage related) in the LV distribution network.

Abstract
Effective utility system management is fundamental and critical for ensuring the normal activities, operations, and services in cities and urban areas. In that regard, the advanced information and communication technologies underpinning smart cities enable close linkages and coordination of different subutility systems, which is now attracting research attention. To increase operational efficiency, we propose a two-stage optimal co-management model for an integrated urban utility system comprised of water, power, gas, and heating systems, namely, integrated water-energy hubs (IWEHs). The proposed IWEH facilitates coordination between multienergy and water sectors via close energy conversion and can enhance the operational efficiency of an integrated urban utility system. In particular, we incorporate social-aware peer-to-peer (P2P) resource trading in the optimization model, in which operators of an IWEH can trade energy and water with other interconnected IWEHs. To cope with renewable generation and load uncertainties and mitigate their negative impacts, a two-stage distributionally robust optimization (DRO) is developed to capture the uncertainties, using a semidefinite programming reformulation. To demonstrate our model's effectiveness and practical values, we design representative case studies that simulate four interconnected IWEH communities. The results show that DRO is more effective than robust optimization (RO) and stochastic optimization (SO) for avoiding excessive conservativeness and rendering practical utilities, without requiring enormous data samples. This work reveals a desirable methodological approach to optimize the water-energy-social nexus for increased economic and system-usage efficiency for the entire (integrated) urban utility system. Furthermore, the proposed model incorporates social participations by citizens to engage in urban utility management for increased operation efficiency of cities and urban areas.

Abstract
Lightning hit a transmission powerline outside London, England on 9 August 2019. There followed a loss of power from a cascade of generator outages that exceeded contingency reserves, leading to an exceptional fall in grid frequency causing widespread transport disruptions and the disconnection of over 1m households. The power outage raised questions about the ability of the GB electricity grid to withstand rapid changes in frequency caused by outages and surges on the network. Grid inertia has been changing in recent years due to the emergence of renewable generation as a significant contributor to the energy mix. As part of climate change mitigation efforts, there has been an acceleration in the deployment of distributed renewable generation replacing conventional thermal power plants in grids across the world. As a result, there has been a change in the aggregate and regional inertial capacity, with consequences for the stability of these networks and their ability to withstand large variations in frequency. Measures to mitigate the consequences of this change to grid stability need to be evaluated and the level of investment required to prevent a reoccurrence of an event such as that of 9 August quantified. Simulating frequency events on the GB grid using a single-bus model involves a system of differential equations representing the overall generation and load present at the time. The standard model based on the swing equation assumes unlimited capacity in aggregated resources, the availability of these services for the duration of the frequency excursion and a homogeneous response without local variation. In simulating the effect of outages on the GB Grid frequency on 9 August 2019 and other events in the period 2018--2019, the effect of limiting these services to the capacity of resources engaged during the event is examined. Taking resource limitations into account enables the approximation of the frequency trace for documented network perturbations. Enhancing this model so that it represents a networked grid using an algebraic differential system of equations facilitates the simulation of the effects of localized variation in inertia and frequency response services on the propagation of transients across a network. Using this model, the effects of varying responses to transients can be investigated, and grids of varying scales and topologies can be compared to determine differences in their response to outages. The propagation of disturbances across domains within the network that have different frequency response characteristics can thereby be examined with a view to drawing conclusions about the optimal deployment of frequency response services, and their relative cost-effectiveness in delivering a stable supply as the proportion of renewable generation in the energy mix grows. The model is demonstrated to be generalizable by its application to simulating an outage on the Italian grid, with the results compared to similar results on that network. This demonstrates the facility of applying the model to examining power systems of different topologies and characteristics, and evaluating plans for their migration to zero-carbon generation. Insight is gained into the responses of various characteristics of the grid and how they interact with unplanned generation imbalances. Using this adapted model, events on the GB grid are examined to validate the influence of these features and evaluate the anticipated response to similar events in the future using energy-mix scenario projections. With the effectiveness of the model validated, novel mitigating measures to preserve the stability of a low-inertia grid can be evaluated.