Abstract
We intend to further the research related to the factors that determine successful entrepreneurial endeavours by academic researchers, and thus put forth an exploratory model of Knowledge-Based Entrepreneurship (KBE). Given the lack of extant adequate indicators, a new scale was developed based on the most frequently cited constructs in the literature. A sample of 1,401 researchers from Portuguese universities was administered a questionnaire and the data collected permitted a validation with regards to the psychometric properties of the questionnaire, to see its applicability to the study. The findings suggest that the absence of a patenting history or start-up portfolio act as significant barriers to academic entrepreneurship. However, when the institutional strategy is to increase patenting and spin-off activities, the university should begin investing in creating a networking environment capable of reinforcing the researchers' Social Capital. Observing the example of successful entrepreneurs motivates other researchers to consider the possibility of developing their own ventures. The Structural Equations Modelling (SEM) approach allowed for us to identify and measure the non-linear relationships that shape the core of KBE and influence the attainment of measurable outcomes aimed at encouraging entrepreneurship. A relatively high share of the variance of the dependent variables is explained by the model, ensuring their representativeness and contributing to the state-of-art of the knowledge in this research field.

Abstract

Abstract
Project-based learning offers a student centered pedagogy and a dynamic approach which promotes a deeper knowledge through real-world challenges and problems solving. The U.Openlab concept is developed at the University of Porto (U.Porto) in the context of the teaching/learning process and is assumed to be an interaction facilitator platform between real-world needs and practical works topics. The aim is to provide innovative answers and the effective use of assessment results, the credits recognition for future professional or scientific careers and a sustainable process oriented for, among others, universities heritage services' needs. The pilot-project in course at the University of Porto, focusing on the U.Porto Digital Museum, includes a technological infrastructure with three main components: several collections, an information and services management platform, with its corresponding digital repository; the U.Porto community contributions management platform (U.Porto OpenLab); and an adaptive framework that will support various interface applications with non-specific audiences. The U.Porto OpenLab considers two main areas: the bidding management area/calls for contributions and a contributions personal management area. The professor, the student and the "client" are the actors in the process. As for main tasks we point out the reception, selection and distribution of real needs/problems. Having concluded the assessment process, results were selected and an online publication was submitted. The inherent credits are recorded in a contributors' digital portfolio management and in the professional social networks profiles. The methodology will be presented and discussed as well as the process along with the obstacles and other factors contributing to the success and future replication of this experience.

Abstract
Innovation has a cost. It is often the case that museums trying to innovate, simply cannot afford what it takes to build truly memorable exhibitions. Lack of human resources and high-tech equipment makes it hard to create quality contents that could be shown to the general public. Nevertheless, universities' museums are usually embedded in an environment that has the potential to provide all the tools and human resources required. The only thing needed is to establish a proper strategy and an interaction facilitator platform - U.OpenLab - which enables creating, building and sharing knowledge about the museums' collections and the academic population. This will make it easier to distribute the aforementioned knowledge to the general public, in a truly sustainable, systematic, integrated and articulated manner. In this paper we are going to present the University of Porto (U.Porto) OpenLab prototype that is being built as the stepping stone of this project, providing students with learning in a project environment.

Abstract
Bone repair is a specialized type of wound repair controlled by complex multi-factorial events. The nervous system is recognized as one of the key regulators of bone mass, thereby suggesting a role for neuronal pathways in bone homeostasis. However, in the context of bone injury and repair, little is known on the interplay between the nervous system and bone. Here, we addressed the neuropeptide Y (NPY) neuronal arm during the initial stages of bone repair encompassing the inflammatory response and ossification phases in femoral-defect mouse model. Spatial and temporal analysis of transcriptional and protein levels of NPY and its receptors, Y1R and Y2R, reported to be involved in bone homeostasis, was performed in bone, dorsal root ganglia (DRG) and hypothalamus after femoral injury. The results showed that NPY system activity is increased in a time- and space-dependent manner during bone repair. Y1R expression was trigged in both bone and DRG throughout the inflammatory phase, while a Y2R response was restricted to the hypothalamus and at a later stage, during the ossification step. Our results provide new insights into the involvement of NPY neuronal pathways in bone repair.

Abstract