Abstract
An innovative, forward-looking organization has a different kind of internal structure, different Marketing and a different way of processing things. Innovative organizations have methods and processes that help them avoid stagnation. In the 21st century we have embraced a whole new technological world. Communicating through social networks is a new phenomenon and organizations must follow this trend, otherwise they will not endure. Companies need to be close to clients and the best way to achieve this is by exploring the new tools that online social media provide (social media includes e-mail and social networks and other such applications). The way people are exposed to information and publicity suffered a real change, as nowadays almost everything is also advertised online. Internet usage and social networking will be the focus of this article. The main research question of this paper is: what is the impact of using social networks on the performance and competitiveness of organizations? This question is relevant since almost every company has access to the Internet, as do their employees. Social networks may also be used for professional purposes as networks that connect everyone to expedite and facilitate communication. On the other hand, social networks may influence productivity negatively. To better discuss the main issue, we will use a Portuguese company as a case study. Thus, we interviewed an employee at BRABBU - the head of the BRABBU Press & Communications department - to establish patterns in the usage of social networks for internal communication during working hours. BRABBU is an award-winning company which won the Best Viral Instagram award, in January 2018, attributed by the Maison et Objet. Furthermore, a sample of the general population was surveyed (we received 352 answers to the survey) to deepen the study of this topic and so as to ascertain whether people think that online social networks help or hinder business performance. The result was clear: social networks may be a great help for internal communication, but this does not replace human contact. Finally, this usage of social networks in the work environment has to reach a consensus amongst the younger generations (e.g. millennial, in favour of this usage) and older ones (e.g. baby boomers, not so receptive to new technologies).

Abstract
This study followed a mixed methodology - five semi-structured interviews were performed, and transcribed in full, with four senior lecturers and one administrative employee at the university; and a survey with 124 valid responses, answered by students of the university, was also conducted. The research question was the following: how does the University of Aveiro achieve its competitive advantage, in view of its competition in Porto, Coimbra and Lisbon, which are the three main geographical areas nearby? The University of Aveiro may also be seen, however, to be competing with other international universities, as the University of Aveiro is highly placed in the international rankings for young universities (the University of Aveiro was, in 2017, ranked 81st in the Times Higher Education Young University Rankings, for universities aged under fifty years). The resources, capabilities and key competences of the University of Aveiro, founded in 1973, were analysed. The results of the study indicate that 76% of the respondents of the survey chose the University of Aveiro as their first choice in their applications, which means that these students are following their first choice for their careers. The University has constructed its attractiveness around value innovation: its low price (not only for its annual fees, but also concerning the cost of living in the Aveiro area - in central Portugal), coupled to its superior and highly recognized teaching practices, its highly recognized research around its 18 research centres, its start-up incubator, its creative science park, its cooperation and knowledge transfer to society (via its many partnerships with different organizations), its multicultural environment (the University of Aveiro is a favourite of Erasmus students), its award-winning campus (in architectural terms), and its organizational culture geared towards the satisfaction of its students, as well as its organizational structure in a matrix format whereby the university is built around different and unique departments (for different functional areas of study) with each having a degree of autonomy, though being managed centrally by the university rectorate. The University of Aveiro is thus seen to be very entrepreneurial as it has remained flexible, dynamic, and principally open to new teaching methods.

Abstract
This paper evaluates the success of an innovative web platform created in 2011 by the Institute for Financing Agriculture and Fisheries (IFAP) named "IFAP Private Account" in which the farmer was registered and accessed their data, their history of correspondence with the Institute, checking the forms they had already submitted as well inspections carried out in the field or administratively. In 2011 the ordinance 86/2011 was published that dictated new procedures by the Institute of Financing of Agriculture and Fisheries, I.P. (IFAP) as the institution allocated the managing of the EAGF (European Agricultural Guarantee Fund) and the EAFRD (European Agricultural Fund for Rural Development). Gradually, the functionalities included in this platform increased the possibility for farmers to submit application forms in their own private accounts. Later, in 2014, IFAP released an APP for Android and iOS smartphones where the beneficiary has access to his or her private account in a faster and more convenient way. For the enabling framework of the target audience of the study it was imperative to do a literature review to carry out an economic and social analysis of the sector and the population living in rural areas and manual labour and agricultural entrepreneurs. Therefore, to understand and characterize IFAP's target public (farmers/beneficiaries) as well as the wherewithal and knowledge they have to access their own private account in an autonomous way, quantifying and characterizing the type of access was a priority. Headquartered in low-density areas, agricultural entrepreneurs present unique opportunities for innovation and differentiation and, at the same time, experience several barriers to growth. Some of these barriers are mentioned in the article in order to raise awareness of the difficulties presented by farmers and inhabitants of rural and peripheral areas. Thus, surveys were directed to farmers and technicians in grassroots entities (associations and cooperatives) in order to understand whether users carry out access to the reserved area autonomously or if they need assistance from others in doing so.

Abstract
Apresenta o Modelo de Gestão do Sistema de Informação Ativa e Permanente (MGSI-AP), resultado de uma investigação que discutiu conceitos e perspetivas em torno da Gestão da Informação, posicionou-a como área transversal e aplicada em Ciência da Informação, com foco no(s) fluxo(s) infocomunicacional(ais), atendendo de forma particular aos que ocorrem em meio digital, no contexto de uma instituição complexa – a universidade pública portuguesa – e respetivos serviços de informação. Aborda um dos eixos da operacionalização da investigação realizada e do modelo desenvolvido. Nele se destaca a estreita ligação da Gestão da Informação à área de estudo da Produção Informacional. A universidade, foco do estudo, é abordada numa dupla faceta sistémica e, consequentemente, complexa, isto é, entre o sistema organizado formal e o sistema combinatório de feição loosely coupled. A formulação de uma proposta teórico-metodológica e de modelação operacional convergiram para uma definição de Gestão da Informação.

Abstract
The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch+RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed. These results suggest that Ch scaffolds embedded with RvD1 were able to lead to the formation of new bone with improvement of trabecular thickness. This study shows that the presence of RvD1 in the acute phase of the inflammatory response to the implanted biomaterial had a positive role in the subsequent bone tissue repair, thus demonstrating the importance of innovative approaches for the control of immune responses to biomedical implants in the design of advanced strategies for regenerative medicine. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1626-1633, 2018.

Abstract
Bone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the plasma miRnome after bone injury and determine its biological implications. Methods: A rat model of femoral bone defect was used, and animals were evaluated at days 3 and 14 after injury. Non-operated (NO) and sham operated animals were used as controls. Blood and spleen were collected and peripheral blood mononuclear cells (PBMC) and plasma were separated. Plasma miRnome was determined by RT-qPCR array and bioinformatics Ingenuity pathway analysis (IPA) was performed. Proliferation of bone marrow mesenchymal stem/stromal cells (MSC) was evaluated by Ki67 staining and high-throughput cell imaging. Candidate miRNAs were evaluated in splenocytes by RT-qPCR, and proteins found in the IPA analysis were analysed in splenocytes and PBMC by Western blot. Results: Bone injury resulted in timely controlled changes to the miRNA expression profile in plasma. At day 3 there was a major down-regulation of miRNA levels, which was partially recovered by day 14 post-injury. Interestingly, bone injury led to a significant up-regulation of let-7a, let-7d and miR-21 in plasma and splenocytes at day 14 relative to day 3 after bone injury, but not in sham operated animals. IPA predicted that most miRNAs temporally affected were involved in cellular development, proliferation and movement. MSC proliferation was analysed and found significantly increased in response to plasma of animals days 3 and 14 post-injury, but not from NO animals. Moreover, IPA predicted that miRNA processing proteins Ago2 and Dicer were specifically inhibited at day 3 post-injury, with Ago2 becoming activated at day 14. Protein levels of Ago2 and Dicer in splenocytes were increased at day 14 relative to day 3 post-bone injury and NO animals, while in PBMC, levels were reduced at day 3 (albeit Dicer was not significant) and remained low at day 14. Ephrin receptor B6 followed the same tendency as Ago2 and Dicer, while Smad2/3 was significantly decreased in splenocytes from day 14 relative to NO and day 3 post-bone injury animals. Conclusion: Results show a systemic miRNA response to bone injury that is regulated in time and is related to inflammation resolution and the start of bone repair/regeneration, unravelling candidate miRNAs to be used as biomarkers in the monitoring of healthy bone healing and as therapeutic targets for the development of improved bone regeneration therapies.