Abstract
Abstract The increasing popularity of attention mechanisms in deep learning algorithms for computer vision and natural language processing made these models attractive to other research domains. In healthcare, there is a strong need for tools that may improve the routines of the clinicians and the patients. Naturally, the use of attention-based algorithms for medical applications occurred smoothly. However, being healthcare a domain that depends on high-stake decisions, the scientific community must ponder if these high-performing algorithms fit the needs of medical applications. With this motto, this paper extensively reviews the use of attention mechanisms in machine learning (including Transformers) for several medical applications. This work distinguishes itself from its predecessors by proposing a critical analysis of the claims and potentialities of attention mechanisms presented in the literature through an experimental case study on medical image classification with three different use cases. These experiments focus on the integrating process of attention mechanisms into established deep learning architectures, the analysis of their predictive power, and a visual assessment of their saliency maps generated by post-hoc explanation methods. This paper concludes with a critical analysis of the claims and potentialities presented in the literature about attention mechanisms and proposes future research lines in medical applications that may benefit from these frameworks.

Abstract

Abstract
3D human pose estimation aims to reconstruct the human skeleton of all the individuals in a scene by detecting several body joints. The creation of accurate and efficient methods is required for several real-world applications including animation, human-robot interaction, surveillance systems or sports, among many others. However, several obstacles such as occlusions, random camera perspectives, or the scarcity of 3D labelled data, have been hampering the models' performance and limiting their deployment in real-world scenarios. The higher availability of cameras has led researchers to explore multi-view solutions due to the advantage of being able to exploit different perspectives to reconstruct the pose. Most existing reviews focus mainly on monocular 3D human pose estimation and a comprehensive survey only on multi-view approaches to determine the 3D pose has been missing since 2012. Thus, the goal of this survey is to fill that gap and present an overview of the methodologies related to 3D pose estimation in multi-view settings, understand what were the strategies found to address the various challenges and also, identify their limitations. According to the reviewed articles, it was possible to find that most methods are fully-supervised approaches based on geometric constraints. Nonetheless, most of the methods suffer from 2D pose mismatches, to which the incorporation of temporal consistency and depth information have been suggested to reduce the impact of this limitation, besides working directly with 3D features can completely surpass this problem but at the expense of higher computational complexity. Models with lower supervision levels were identified to overcome some of the issues related to 3D pose, particularly the scarcity of labelled datasets. Therefore, no method is yet capable of solving all the challenges associated with the reconstruction of the 3D pose. Due to the existing trade-off between complexity and performance, the best method depends on the application scenario. Therefore, further research is still required to develop an approach capable of quickly inferring a highly accurate 3D pose with bearable computation cost. To this goal, techniques such as active learning, methods that learn with a low level of supervision, the incorporation of temporal consistency, view selection, estimation of depth information and multi-modal approaches might be interesting strategies to keep in mind when developing a new methodology to solve this task.

Abstract

Abstract
Deep-learning techniques can improve the efficiency of medical diagnosis while challenging human experts’ accuracy. However, the rationale behind these classifier’s decisions is largely opaque, which is dangerous in sensitive applications such as healthcare. Case-based explanations explain the decision process behind these mechanisms by exemplifying similar cases using previous studies from other patients. Yet, these may contain personally identifiable information, which makes them impossible to share without violating patients’ privacy rights. Previous works have used GANs to generate anonymous case-based explanations, which had limited visual quality. We solve this issue by employing a latent diffusion model in a three-step procedure: generating a catalogue of synthetic images, removing the images that closely resemble existing patients, and using this anonymous catalogue during an explanation retrieval process. We evaluate the proposed method on the MIMIC-CXR-JPG dataset and achieve explanations that simultaneously have high visual quality, are anonymous, and retain their explanatory value.

Abstract
The main challenges hindering the adoption of deep learning-based systems in clinical settings are the scarcity of annotated data and the lack of interpretability and trust in these systems. Concept Bottleneck Models (CBMs) offer inherent interpretability by constraining the final disease prediction on a set of human-understandable concepts. However, this inherent interpretability comes at the cost of greater annotation burden. Additionally, adding new concepts requires retraining the entire system. In this work, we introduce a novel two-step methodology that addresses both of these challenges. By simulating the two stages of a CBM, we utilize a pretrained Vision Language Model (VLM) to automatically predict clinical concepts, and an off-the-shelf Large Language Model (LLM) to generate disease diagnoses grounded on the predicted concepts. Furthermore, our approach supports test-time human intervention, enabling corrections to predicted concepts, which improves final diagnoses and enhances transparency in decision-making. We validate our approach on three skin lesion datasets, demonstrating that it outperforms traditional CBMs and state-of-the-art explainable methods, all without requiring any training and utilizing only a few annotated examples. The code is available at https://github.com/CristianoPatricio/2step-concept-based-skin-diagnosis.