Abstract
[No abstract available]

Abstract
In order to facilitate the adoption of deep learning in areas where decisions are of critical importance, understanding the model's internal workings is paramount. Nevertheless, since most models are considered black boxes, this task is usually not trivial, especially when the user does not have access to the network's intermediate outputs. In this paper, we propose IBISA, a model-agnostic attribution method that reaches state-of-the-art performance by optimizing sampling masks using the Information Bottleneck Principle. Our method improves on the previously known RISE and IBA techniques by placing the bottleneck right after the image input without complex formulations to estimate the mutual information. The method also requires only twenty forward passes and ten backward passes through the network, which is significantly faster than RISE, which needs at least 4000 forward passes. We evaluated IBISA using a VGG-16 and a ResNET-50 model, showing that our method produces explanations comparable or superior to IBA, RISE, and Grad-CAM but much more efficiently. © 2025 The Authors

Abstract
Due to the high variability in Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs), hidden stratification, and batch effects, generalizing beyond the training distribution is one of the main challenges in Deep Learning (DL) for Computational Pathology (CPath). But although DL depends on large volumes of diverse and annotated data, it is common to have a significant number of annotated samples from one or multiple source distributions, and another partially annotated or unlabeled dataset representing a target distribution for which we want to generalize, the so-called Domain Adaptation (DA). In this work, we focus on the task of generalizing from a single source distribution to a target domain. As it is still not clear which domain adaptation strategy is best suited for CPath, we evaluate three different DA strategies, namely FixMatch, CycleGAN, and a self-supervised feature extractor, and show that DA is still a challenge in CPath.