Abstract
Purpose: This paper presents the Rehab@home system, a tool specifically developed for helping neurological patients performing rehabilitation exercises at home, without the presence of a physiotherapist. It is centred on the rehabilitation of balance and on the sit-to-stand (STS) movement. Method: Rehab@home is composed of two Wii balance boards, a webcam and a computer, and it has two main software applications: one for patients to perform rehabilitation exercises and another one for therapists to visualize the data of the exercises. During the exercises, data from the boards and the webcam are processed in order to automatically assess the correctness of movements. Results: Rehab@home provides exercises for the rehabilitation of balance (in sitting and in standing positions), and for the execution of the STS movement. It gives automatic feedback to the patient and data are saved for future analysis. The therapist is able to adapt the difficulty of the exercises to match with each patient's needs. A preliminary study with seven patients was conducted for evaluating their feedback. They appreciated using the system and felt the exercises more engaging than conventional therapy. Conclusions: Feedback from patients gives the hope that Rehab@home can become a great tool for complementing their rehabilitation process.

Abstract
A new approach is introduced for the automatic detection of the lumen axis of the common carotid artery in B-mode ultrasound images. The image is smoothed using a Gaussian filter and then a dynamic programming scheme extracts the dominant paths of local minima of the intensity and the dominant paths of local maxima of the gradient magnitude with the gradient pointing downwards. Since these paths are possible estimates of the lumen axis and the far wall of a blood vessel, respectively, they are grouped together into pairs. Then, a pattern of two features is computed from each pair of paths and used as input to a linear discriminant classifier in order to select the pair of paths that correspond to the common carotid artery. The estimated lumen axis is the path of local minima of the intensity that belongs to the selected pair of paths. The proposed method is suited to real time processing, no user interaction is required and the number of parameters is minimal and easy to determine. The validation was performed using two datasets, with a total of 199 images, and has shown a success rate of 99.5% (100% if only the carotid regions for which a ground truth is available are considered). The datasets have a large diversity of images, including cases of arteries with plaque and images with heavy noise, text or other graphical markings inside the artery region.

Abstract
This chapter surveys methodologies for the segmentation of carotid ultrasound images and describes a method for the semiautomatic detection of the lumen-intima and the media-adventitia interfaces of the near and far common carotid wall. The approach is based on feature extraction, fitting of cubic splines, dynamic programming, smooth intensity thresholding surfaces, and geometric snakes. A set of 47 B-mode images of the common carotid were used to assess the performance of the method. The detection errors are similar to the ones observed in manual segmentations for 95% of the far wall interfaces and 73% of the near wall interfaces. © 2014 Springer Science+Business Media, LLC. All rights are reserved.

Abstract
The choroid is the middle layer of the eye globe located between the retina and the sclera. It is proven that choroidal thickness is a sign of multiple eye diseases. Optical Coherence Tomography (OCT) is an imaging technique that allows the visualization of tomographic images of near surface tissues like those in the eye globe. The automatic calculation of the choroidal thickness reduces the subjectivity of manual image analysis as well as the time of large scale measurements. In this paper, a method for the automatic estimation of the choroidal thickness from OCT images is presented. The pre-processing of the images is focused on noise reduction, shadow removal and contrast adjustment. The inner and outer boundaries of the choroid are delineated sequentially, resorting to a minimum path algorithm supported by new dedicated cost matrices. The choroidal thickness is given by the distance between the two boundaries. The data are then interpolated and mapped to an infrared image of the eye fundus. The method was evaluated by calculating the error as the distance from the automatically estimated boundaries to the boundaries delineated by an ophthalmologist. The error of the automatic segmentation was low and comparable to the differences between manual segmentations from different ophthalmologists.

Abstract

Abstract
An accurate detection of the macular edema (ME) presence constitutes a crucial ophthalmological issue as it provides useful information for the identification, diagnosis and treatment of different relevant ocular and Systemic diseaseS. serous Retinal Detachment (sRD) is a particular type of ME, which is characterized by the leakage of fluid that has a propensity of being accumulated in the macular region. This paper proposes a new methodology for the automatic identification and characterization of the sRD edema using Optical Coherence Tomography (OCT) imageS. The subretinal fluids and the External Limiting Membrane (ELM) retinal layers are identified and characterized to measure the disease severity. Four different visualization modules were designed including representative derived parameters to facilitate the doctor's work in the diagnostic evaluation of ME. The different steps of this method were validated using the manual labelling provided by an expert clinician. The validation of the proposed method offered satisfactory results, constituting a suitable scenario with intuitive visual representations that also include different relevant biomarkerS. © 2018 The Author(s).