Abstract

Abstract
Abstract Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of paramount importance for precision medicine. Machine learning(ML) algorithms can be trained on high-throughput screening data to develop models that are able to predict the response of cancer cell lines and patients to novel drugs or drug combinations. Deep learning (DL) refers to a distinct class of ML algorithms that have achieved top-level performance in a variety of fields, including drug discovery. These types of models have unique characteristics that may make them more suitable for the complex task of modeling drug response based on both biological and chemical data, but the application of DL to drug response prediction has been unexplored until very recently. The few studies that have been published have shown promising results, and the use of DL for drug response prediction is beginning to attract greater interest from researchers in the field. In this article, we critically review recently published studies that have employed DL methods to predict drug response in cancer cell lines. We also provide a brief description of DL and the main types of architectures that have been used in these studies. Additionally, we present a selection of publicly available drug screening data resources that can be used to develop drug response prediction models. Finally, we also address the limitations of these approaches and provide a discussion on possible paths for further improvement. Contact:mrocha@di.uminho.pt

Abstract

Abstract
Probabilistic forecasting of distribution tails (i.e., quantiles below 0.05 and above 0.95) is challenging for non-parametric approaches since data for extreme events are scarce. A poor forecast of extreme quantiles can have a high impact in various power system decision-aid problems. An alternative approach more robust to data sparsity is extreme value theory (EVT), which uses parametric functions for modelling distribution's tails. In this work, we apply conditional EVT estimators to historical data by directly combining gradient boosting trees with a truncated generalized Pareto distribution. The parametric function parameters are conditioned by covariates such as wind speed or direction from a numerical weather predictions grid. The results for a wind power plant located in Galicia, Spain, show that the proposed method outperforms state-of-the-art methods in terms of quantile score. © 2020 Elsevier B.V.

Abstract

Abstract