Abstract
The learning from continuous data streams is a relevant area within machine learning, focusing on the creation and updating of predictive models in real time as new data becomes available for training and prediction. Among the most widely used methods for this type of task, Hoeffding Trees are highly valued for their simplicity and robustness across a variety of applications and are considered the primary choice for generating decision trees in data stream contexts. However, Hoeffding Trees tend to continuously expand as new data is incorporated, resulting in increased processing time and memory consumption, often without providing significant gains in accuracy. In this study, we propose an instance selection scheme that combines different strategies to regularize Hoeffding Trees and their variants, mitigating excessive growth without compromising model accuracy. The method selects misclassified instances and a fraction of correctly classified instances during the training phase. After extensive experimental evaluation, the instance selection scheme demonstrates superior predictive performance compared to the original models (without selection), for both real and synthetic datasets for data streams, using a reduced subset of examples. Additionally, the method achieves relevant improvements in processing time, model complexity, and memory consumption, highlighting the effectiveness of the proposed instance selection scheme. Copyright © 2025 held by the owner/author(s).

Abstract
Multimodal models, namely vision-language models, present unique possibilities through the seamless integration of different information mediums for data generation. These models mostly act as a black-box, making them lack transparency and explicability. Reliable results require accountable and trustworthy Artificial Intelligence (AI), namely when in use for critical tasks, such as the automatic generation of medical imaging reports for healthcare diagnosis. By exploring stress-testing techniques, multimodal generative models can become more transparent by disclosing their shortcomings, further supporting their responsible usage in the medical field. Copyright © 2025, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

Abstract

Abstract
In healthcare, diagnoses usually rely on physician expertise. However, complex cases may benefit from consulting similar past clinical reports cases. In this paper, we present MedLink (http://medlink.inesctec.pt), a tool that given a free-text medical report, retrieves and ranks relevant clinical case reports published in health conferences and journals, aiming to support clinical decision-making, particularly in challenging or complex diagnoses. To this regard, we trained two BERT models on the sentence similarity task: a bi-encoder for retrieval and a cross-encoder for reranking. To evaluate our approach, we used 10 medical reports and asked a physician to rank the top 10 most relevant published case reports for each one. Our results show that MedLink’s ranking model achieved NDCG@10 of 0.747. Our demo also includes the visualization of clinical entities (using a NER model) and the production of a textual explanation (using a LLM) to ease comparison and contrasting between reports. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

Abstract

Abstract
Background: Tobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular mechanisms driving smoking-related health decline and aging acceleration in most tissues remain unexplored. Methods: Here, we use data from the Genotype-Tissue Expression Project (GTEx) to perform a characterization of the effect of cigarette smoking across human tissues. We perform a multi-tissue analysis across 46 human tissues. Our multi-omics characterization includes analysis of gene expression, alternative splicing, DNA methylation, and histological alterations. We further analyze ex-smoker samples to assess the reversibility of these molecular alterations upon smoking cessation. Results: We show that smoking impacts tissue architecture and triggers systemic inflammation. We find that in many tissues, the effects of smoking significantly overlap those of aging. Specifically, both age and smoking upregulate inflammatory genes and drive hypomethylation at enhancers (odds ratio (OR) = 2). In addition, we observe widespread smoking-driven hypermethylation at target regions of the Polycomb repressive complex (OR = 2), which is a well-known aging effect. Smoking-induced epigenetic changes overlap causal aging CpGs, suggesting that these methylation changes may directly mediate the aging acceleration observed in smokers. Finally, we find that smoking effects that are shared with aging are more persistent over time. Conclusion: Overall, our multi-tissue and multi-omic analysis of the effects of cigarette smoking provides an extensive characterization of the impact of tobacco smoke across tissues and unravels the molecular mechanisms driving smoking-induced tissue homeostasis decline and aging acceleration. © The Author(s) 2025.