Abstract

Abstract

Abstract
In this study, we used machine learning techniques to reconstruct the wavelength dependence of the absorption coefficient of human normal and pathological colorectal mucosa tissues. Using only diffuse reflectance spectra from the ex vivo mucosa tissues as input to algorithms, several approaches were tried before obtaining good matching between the generated absorption coefficients and the ones previously calculated for the mucosa tissues from invasive experimental spectral measurements. Considering the optimized match for the results generated with the multilayer perceptron regression method, we were able to identify differentiated accumulation of lipofuscin in the absorption coefficient spectra of both mucosa tissues as we have done before with the corresponding results calculated directly from invasive measurements. Considering the random forest regressor algorithm, the estimated absorption coefficient spectra almost matched the ones previously calculated. By subtracting the absorption of lipofuscin from these spectra, we obtained similar hemoglobin ratios at 410/550 nm: 18.9-fold/9.3-fold for the healthy mucosa and 46.6-fold/24.2-fold for the pathological mucosa, while from direct calculations, those ratios were 19.7-fold/10.1-fold for the healthy mucosa and 33.1-fold/17.3-fold for the pathological mucosa. The higher values obtained in this study indicate a higher blood content in the pathological samples used to measure the diffuse reflectance spectra. In light of such accuracy and sensibility to the presence of hidden absorbers, with a different accumulation between healthy and pathological tissues, good perspectives become available to develop minimally invasive spectroscopy methods for in vivo early detection and monitoring of colorectal cancer. © 2021 Author(s).

Abstract
The usage of unmanned aerial vehicles (UAV) has increased in recent years and new application scenarios have emerged. Some of them involve tasks that require a high degree of autonomy, leading to increasingly complex systems. In order for a robot to be autonomous, it requires appropriate perception sensors that interpret the environment and enable the correct execution of the main task of mobile robotics: navigation. In the case of UAVs, flying at low altitude greatly increases the probability of encountering obstacles, so they need a fast, simple, and robust method of collision avoidance. This work covers the problem of navigation in unknown scenarios by implementing a simple, yet robust, environment-reactive approach. The implementation is done with both CPU and GPU map representations to allow wider coverage of possible applications. This method searches for obstacles that cross a cylindrical safety volume, and selects an escape point from a spiral for avoiding the obstacle. The algorithm is able to successfully navigate in complex scenarios, using both a high and low-power computer, typically found aboard UAVs, relying only on a depth camera with a limited FOV and range. Depending on the configuration, the algorithm can process point clouds at nearly 40 Hz in Jetson Nano, while checking for threats at 10 kHz. Some preliminary tests were conducted with real-world scenarios, showing both the advantages and limitations of CPU and GPU-based methodologies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Abstract
Cervical cancer ranks as the fourth most common cancer among females worldwide with roughly 528, 000 new cases yearly. Significant progress in the realm of artificial intelligence particularly in neural networks and deep learning help physicians to diagnose cervical cancer more accurately. In this paper, we address a classification problem with the widely used VGG16 architecture. In addition to classification error, our model considers a regularization part during tuning of the weights, acting as prior knowledge of the colposcopic image. This embedded regularization approach, using a 2D Gaussian kernel, has enabled the model to learn which sections of the medical images are more crucial for the classification task. The experimental results show an improvement compared with standard transfer learning and multimodal approaches of cervical cancer classification in literature. © 2021 IEEE.

Abstract
The concepts brought by Industry 4.0 have been explored and gradually applied.The cybersecurity impacts on the progress of Industry 4.0 implementations and their interactions with other technologies require constant surveillance, and it is important to forecast cybersecurity-related challenges and trends to prevent and mitigate these impacts. The contributions of this paper are as follows: (1) it presents the results of a systematic review of industry 4.0 regarding attacks, vulnerabilities and defense strategies, (2) it details and classifies the attacks, vulnerabilities and defenses mechanisms, and (3) it presents a discussion of recent challenges and trends regarding cybersecurity-related areas for Industry 4.0. From the systematic review, regarding the attacks, the results show that most attacks are carried out on the network layer, where dos-related and mitm attacks are the most prevalent ones. Regarding vulnerabilities, security flaws in services and source code, and incorrect validations in authentication procedures are highlighted. These are vulnerabilities that can be exploited by dos attacks and buffer overflows in industrial devices and networks. Regarding defense strategies, Blockchain is presented as one of the most relevant technologies under study in terms of defense mechanisms, thanks to its ability to be used in a variety of solutions, from Intrusion Detection Systems to the prevention of Distributed dos attacks, and most defense strategies are presented as an after-attack solution or prevention, in the sense that the defense mechanisms are only placed or thought, only after the harm has been done, and not as a mitigation strategy to prevent the cyberattack. Concerning challenges and trends, the review shows that digital sovereignty, cyber sovereignty, and data sovereignty are recent topics being explored by researchers within the Industry 4.0 scope, and GAIA-X and International Data Spaces are recent initiatives regarding data sovereignty. A discussion of trends is provided, and future challenges are pointed out.