Vítor Santos Costa

Abstract
Diabetes management is a complex problem. The patient needs to monitor several parameters in order to react in the most appropriate way. Different situations require the diabetic to understand and evaluate different rules. The main source of knowledge for those rules arises from medical practice and is usually transmitted through medical appointments. Given this initial advice, most patient are on a continuous process of managing the disease, toward achieving the best possible quality of life. Motivated by recent aadvances in diabetes monitoring devices, we introduce a diabetes support system designed to accompany the user, advising her and providing early guidance to avoid some of the many complications associated with diabetes. To accomplish this goal, we incorporate standard medical protocols, advice and directives in a Rule Based System (RBS). This RBS which we call Advice Rule Based System (ARBS) is capable of advising and uncovering possible causes for different occurrences. We believe that this solution is not only beneficial to the patient, but may also may be of use to the clinitians advising the patient. The device has continuous contact with the patient, thus it can provide early response if/where needed, Moreover, the system can provide useful data, that an authorized medical expert can use while prescribing a particular treatment, or even when investingating this health problem. We have started to add data-mining algorithms and methods, to uncover hidden behavioural patterns that may lead to crisis situations. Ultimately, through refining the rule systems base don human and machine learning, our approach has the potential for personalising the system according to the habits and phenotype of its user. The system is to be incorporated in a currently developed diabetes management application for Android.

Abstract
Diabetes management is a complex and a sensible problem as each diabetic is a unique case with particular needs. The optimal solution would be a constant monitoring of the diabetic's values and automatically acting accordingly. We propose an approach that guides the user and analyses the data gathered to give individual advice. By using data mining algorithms and methods, we uncover hidden behaviour patterns that may lead to crisis situations. These patterns can then be transformed into logical rules, able to trigger in a particular context, and advise the user. We believe that this solution, is not only beneficial for the diabetic, but also for the doctor accompanying the situation. The advice and rules are useful input that the medical expert can use while prescribing a particular treatment. During the data gathering phase, when the number of records is not enough to attain useful conclusions, a base set of logical rules, defined from medical protocols, directives and/or advice, is responsible for advise and guiding the user. The proposed system will accompany the user at start with generic advice, and with constant learning, advise the user more specifically. We discuss this approach describing the architecture of the system, its base rules and data mining component. The system is to be incorporated in a currently developed diabetes management application for Android. © 2017 IEEE.

Abstract
Adverse drug events (ADEs) are a major concern and point of emphasis for the medical profession, government, and society. A diverse set of techniques from epidemiology, statistics, and computer science are being proposed and studied for ADE discovery from observational health data (e.g., EHR and claims data), social network data (e.g., Google and Twitter posts), and other information sources. Methodologies are needed for evaluating, quantitatively measuring and comparing the ability of these various approaches to accurately discover ADEs. This work is motivated by the observation that text sources such as the Medline/Medinfo library provide a wealth of information on human health. Unfortunately, ADEs often result from unexpected interactions, and the connection between conditions and drugs is not explicit in these sources. Thus, in this work, we address the question of whether we can quantitatively estimate relationships between drugs and conditions from the medical literature. This paper proposes and studies a state-of-the-art NLP-based extraction of ADEs from text.

Abstract
Several prominent public health incidents [29] that occurred at the beginning of this century due to adverse drug events (ADEs) have raised international awareness of governments and industries about pharmacovigilance (PhV) [6, 7], the science and activities to monitor and prevent adverse events caused by pharmaceutical products after they are introduced to the market. A major data source for PhV is large-scale longitudinal observational databases (LODs) [6] such as electronic health records (EHRs) and medical insurance claim databases. Inspired by the Multiple Self-Controlled Case Series (MSCCS) model [27], arguably the leading method for ADE discovery from LODs, we propose baseline regularization, a regularized generalized linear model that leverages the diverse health profiles available in LODs across different individuals at different times. We apply the proposed method as well as MSCCS to the Marshfield Clinic EHR. Experimental results suggest that incorporatingthe heterogeneity among different patients and different times help to improve the performance in identifying benchmark ADEs from the Observational Medical Outcomes Partnership ground truth [26]. © 2017 Copyright held by the owner/author(s).

Abstract
Theory Revision from Examples is the process of repairing incorrect theories and/or improving incomplete theories from a set of examples. This process usually results in more accurate and comprehensible theories than purely inductive learning. However, so far, progress on the use of theory revision techniques has been limited by the large search space they yield. In this article, we argue that it is possible to reduce the search space of a theory revision system by introducing stochastic local search. More precisely, we introduce a number of stochastic local search components at the key steps of the revision process, and implement them on a state-of-the-art revision system that makes use of the most specific clause to constrain the search space. We show that with the use of these SLS techniques it is possible for the revision system to be executed in a feasible time, while still improving the initial theory and in a number of cases even reaching better accuracies than the deterministic revision process. Moreover, in some cases the revision process can be faster and still achieve better accuracies than an ILP system learning from an empty initial hypothesis or assuming an initial theory to be correct.