Abstract
Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol, is one of these parameters, and controlling its variations allows for optimization of the production process. In this study, a refractometric sensor, implemented by an interrogation system based on an Erbium-Doped Fiber Ring Cavity (EDFRC), was presented and experimentally demonstrated. The Cavity Ring proposed included a 1 x 3 coupler. One port of the coupler was used to increase the optical power of the system through a Fiber Bragg Grating (FBG), and the other two ports were used as sensing head and reference. The sensor detected variations of paracetamol concentration with a sensitivity of [(-1.00 +/- 0.05) x 10(-3)] nW/(g/kg) and a resolution of 5.53 g/kg. The results demonstrate the potential of this technology as a possible non-invasive PAT tool.

Abstract

Abstract
A linear fiber laser system for measurements of paracetamol concentration is experimentally demonstrated. The cavity is based on a fiber loop mirror and an FBG centered at 1567.8 nm. The sensing head corresponds to a refractometric sensor, whose which principle of operation is based on Fresnel reflection in the fiber tip (FBG side). The system works at detected variations of paracetamol concentrations with a sensitivity of [(8.74 +/- 0.34) x10(-5)] mu W/(g/kg) and a resolution of 2.77 g/kg. The results prove that the fiber laser system could be an asset for processing industries, specifically for non-invasive and real-time measurements of concentration.

Abstract
Using surface resonance (SPR) as a sensitivity enhancer, this work describes the development of a transmissive multimode optical fiber sensor with a gold (Au) thin film that measures glucose concentration. The fiber's cladding was initially removed, and an Au layer was then sputtered onto its surface to simultaneously excite SPR and reflect light, making the SPR sensor extremely sensitive to changes in the environment's refractive index. A range of glucose concentrations, from 0.0001 to 0.5000 g/ml, were tested on the sensor. A maximum sensitivity of 161.302 nm/(g/mL) was attained for the lowest glucose concentration, while the highest concentration yielded a sensitivity of 312.000 nm/(g/mL). The proposed sensor's compact size, high sensitivity, good stability and practicality make it a promising candidate for a range of applications, including detecting diabetes.

Abstract
A paracetamol concentration-sensing scheme based on a linear cavity fiber laser configuration is demonstrated experimentally. The laser cavity has a fiber sensor at one end, that allows refractive index measurements. The refractometer consists of a cleaved fiber tip combined with an FBG functioning as a reflecting mirror. The combination of a fiber loop mirror at the other end allows to reflect all the light from the FBG and refractometer, forming a linear cavity. By measuring the intensity variation of the Fresnel reflection at the fiber-to-liquid interface, the measured concentration is linear and have a concentration sensitivity of [( - 8.74 & PLUSMN; 0.34) x 10-5 ] & mu;W/(g/kg), over a range of 52.61 to 219.25 g/kg, and with a resolution of 2.77 g/kg. The results obtained present high stability and prove the potential of the fiber laser system to performed realtime measurements of concentration, in a non-invasive way.