Detalhes
Nome
Susana NovaisCargo
Investigador AuxiliarDesde
01 abril 2019
Nacionalidade
PortugalCentro
Centro de Fotónica AplicadaContactos
+351220402301
susana.novais@inesctec.pt
2024
Autores
Soares, L; Pérez Herrera, RA; Novais, S; Ferreira, A; Silva, S; Frazão, O;
Publicação
Abstract
2024
Autores
Cunha, C; Monteiro, C; Vaz, A; Silva, S; Frazao, O; Novais, S;
Publicação
SENSORS
Abstract
This paper presents an approach to enhancing sensitivity in optical sensors by integrating self-image theory and graphene oxide coating. The sensor is specifically engineered to quantitatively assess glucose concentrations in aqueous solutions that simulate the spectrum of glucose levels typically encountered in human saliva. Prior to sensor fabrication, the theoretical self-image points were rigorously validated using Multiphysics COMSOL 6.0 software. Subsequently, the sensor was fabricated to a length corresponding to the second self-image point (29.12 mm) and coated with an 80 mu m/mL graphene oxide film using the Layer-by-Layer technique. The sensor characterization in refractive index demonstrated a wavelength sensitivity of 200 +/- 6 nm/RIU. Comparative evaluations of uncoated and graphene oxide-coated sensors applied to measure glucose in solutions ranging from 25 to 200 mg/dL showed an eightfold sensitivity improvement with one bilayer of Polyethyleneimine/graphene. The final graphene oxide-based sensor exhibited a sensitivity of 10.403 +/- 0.004 pm/(mg/dL) and demonstrated stability with a low standard deviation of 0.46 pm/min and a maximum theoretical resolution of 1.90 mg/dL.
2023
Autores
Soares, L; Perez Herrera, RA; Novais, S; Ferreira, A; Silva, S; Frazao, O;
Publicação
PHOTONICS
Abstract
Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol, is one of these parameters, and controlling its variations allows for optimization of the production process. In this study, a refractometric sensor, implemented by an interrogation system based on an Erbium-Doped Fiber Ring Cavity (EDFRC), was presented and experimentally demonstrated. The Cavity Ring proposed included a 1 x 3 coupler. One port of the coupler was used to increase the optical power of the system through a Fiber Bragg Grating (FBG), and the other two ports were used as sensing head and reference. The sensor detected variations of paracetamol concentration with a sensitivity of [(-1.00 +/- 0.05) x 10(-3)] nW/(g/kg) and a resolution of 5.53 g/kg. The results demonstrate the potential of this technology as a possible non-invasive PAT tool.
2023
Autores
Perez Herrera, RA; Soares, L; Novais, S; Frazão, O; Silva, S;
Publicação
Proceedings of SPIE - The International Society for Optical Engineering
Abstract
2023
Autores
Soares, L; Perez-Herrera, RA; Novais, S; Ferreira, A; Frazao, O; Silva, S;
Publicação
2023 IEEE 7TH PORTUGUESE MEETING ON BIOENGINEERING, ENBENG
Abstract
A linear fiber laser system for measurements of paracetamol concentration is experimentally demonstrated. The cavity is based on a fiber loop mirror and an FBG centered at 1567.8 nm. The sensing head corresponds to a refractometric sensor, whose which principle of operation is based on Fresnel reflection in the fiber tip (FBG side). The system works at detected variations of paracetamol concentrations with a sensitivity of [(8.74 +/- 0.34) x10(-5)] mu W/(g/kg) and a resolution of 2.77 g/kg. The results prove that the fiber laser system could be an asset for processing industries, specifically for non-invasive and real-time measurements of concentration.
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