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Details

  • Name

    Liliana Patrícia Soares
  • Role

    Research Assistant
  • Since

    23rd January 2019
  • Nationality

    Portugal
  • Centre

    Applied Photonics
  • Contacts

    +351220402301
    liliana.p.soares@inesctec.pt
Publications

2021

Application of a Fiber Optic Refractometric Sensor to Measure the Concentration of Paracetamol in Crystallization Experiments

Authors
Soares, L; Cruz, P; Novais, S; Ferreira, A; Frazao, O; Silva, S;

Publication
IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE

Abstract
A refractometric sensor was applied to measure in real-time the concentration of Active Pharmaceutical Ingredients (APIs) in crystallization experiments. Paracetamol was used as a model system due to the extensive literature available for this API. The refractometric sensor was fabricated by a simple and inexpensive method that consisted in splicing a short section of a multimode fiber to a single mode fiber. The compact geometry of this sensor, with an external diameter of just $125\ \mu\mathrm{m}$, allowed it to measure the concentration of paracetamol, both in a stirred tank crystallizer operating in batch and in an oscillatory flow crystallizer operating continuously. The proposed technique shows the potential to monitor the concentration of APIs in crystallizers of different sizes and geometries as an alternative to more expensive and complex analysis equipment.