Details
Name
Liliana Patrícia SoaresCluster
Networked Intelligent SystemsRole
Research AssistantSince
23rd January 2019
Nationality
PortugalCentre
Applied PhotonicsContacts
+351220402301
liliana.p.soares@inesctec.pt
2021
Authors
Soares, L; Cruz, P; Novais, S; Ferreira, A; Frazao, O; Silva, S;
Publication
IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE
Abstract
A refractometric sensor was applied to measure in real-time the concentration of Active Pharmaceutical Ingredients (APIs) in crystallization experiments. Paracetamol was used as a model system due to the extensive literature available for this API. The refractometric sensor was fabricated by a simple and inexpensive method that consisted in splicing a short section of a multimode fiber to a single mode fiber. The compact geometry of this sensor, with an external diameter of just $125\ \mu\mathrm{m}$, allowed it to measure the concentration of paracetamol, both in a stirred tank crystallizer operating in batch and in an oscillatory flow crystallizer operating continuously. The proposed technique shows the potential to monitor the concentration of APIs in crystallizers of different sizes and geometries as an alternative to more expensive and complex analysis equipment.
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