Abstract

Abstract

Abstract
Sound-based uroflowmetry (SU) is a non-invasive technique emerging as an alternative to traditional uroflowmetry (UF) to calculate the voiding flow rate based on the sound generated by the urine impacting the water in a toilet, enabling remote monitoring and reducing the patient burden and clinical costs. This study trains four different machine learning (ML) models (random forest, gradient boosting, support vector machine and convolutional neural network) using both regression and classification approaches to predict and categorize the voiding flow rate from sound events. The models were trained with a dataset that contains sounds from synthetic void events generated with a high precision peristaltic pump and a traditional toilet. Sound was simultaneously recorded with three devices: Ultramic384k, Mi A1 smartphone and Oppo Smartwatch. To extract the audio features, our analysis showed that segmenting the audio signals into 1000 ms segments with frequencies up to 16 kHz provided the best results. Results show that random forest achieved the best performance in both regression and classification tasks, with a mean absolute error (MAE) of 0.9, 0.7 and 0.9 ml/s and quadratic weighted kappa (QWK) of 0.99, 1.0 and 1.0 for the three devices. To evaluate the models in a real environment and assess the effectiveness of training with synthetic data, the best-performing models were retrained and validated using a real voiding sounds dataset. The results reported an MAE below 2.5 ml/s and a QWK above 0.86 for regression and classification tasks, respectively.

Abstract

Abstract
Physiological signals are often corrupted by noisy sources. Usually, artificial intelligence algorithms analyze the whole signal, regardless of its varying quality. Instead, experienced cardiologists search for a high-quality signal segment, where more accurate conclusions can be draw. We propose a methodology that simultaneously selects the optimal processing region of a physiological signal and determines its decoding into a state sequence of physiologically meaningful events. Our approach comprises two phases. First, the training of a neural network that then enables the estimation of the state probability distribution of a signal sample. Second, the use of the neural network output within an integer program. The latter models the problem of finding a time window by maximizing a likelihood function defined by the user. Our method was tested and validated in two types of signals, the phonocardiogram and the electrocardiogram. In phonocardiogram and electrocardiogram segmentation tasks, the system's sensitivity increased on average from 95.1% to 97.5% and from 78.9% to 83.8%, respectively, when compared to standard approaches found in the literature.