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Details

  • Name

    Catarina Moreira Marques
  • Role

    Assistant Researcher
  • Since

    01st September 2015
005
Publications

2024

Deep Reinforcement Learning-Based Approach to Dynamically Balance Multi-manned Assembly Lines

Authors
Santos, R; Marques, C; Toscano, C; Ferreira, M; Ribeiro, J;

Publication
Lecture Notes in Mechanical Engineering

Abstract
Assembly lines are at the core of many manufacturing systems, and planning for a well-balanced flow is key to ensure long-term efficiency. However, in flexible configurations such as Multi-Manned Assembly Lines (MMAL), the balancing problem also becomes more challenging. Due to the increased relevance of these assembly lines, this work aims to investigate the MMAL balancing problem, to contribute for a more effective decision-making process. Therefore, a new approach is proposed based on Deep Reinforcement Learning (DRL) embedded in a Digital Twin architecture. The proposed approach provides a close-to-reality training environment for the agent, using Discrete Event Simulation to simulate the production system dynamics. This methodology was tested on a real-world instance with preliminary results showing that similar solutions to the ones obtained using optimization-based strategies are achieved. This research provides evidence of success in terms of dynamic resource assignment to tasks and workers as a basis for future developments. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

2023

A Simulation Approach for the Design of More Sustainable and Resilient Supply Chains in the Pharmaceutical Industry

Authors
Silva, AC; Marques, CM; de Sousa, JP;

Publication
SUSTAINABILITY

Abstract
In a world facing unprecedented challenges, such as climate changes and growing social problems, the pharmaceutical industry must ensure that its supply chains are environmentally sustainable and resilient, guaranteeing access to key medications even when faced with unanticipated disruptions or crises. The core goal of this work is to develop an innovative simulation-based approach to support more informed and effective decision making, while establishing reasonable trade-offs between supply chain robustness and resiliency, operational efficiency, and environmental and social concerns. Such a decision-support system will contribute to the development of more resilient and sustainable pharmaceutical supply chains, which are, in general, critical for maintaining access to essential medicines, especially during times of crises or relevant disruptions. The system will help companies to better manage and design their supply chains, providing a valuable tool to achieve higher levels of resilience and sustainability. The study we conducted has two primary contributions that are noteworthy. Firstly, we present a new advanced approach that integrates multiple simulation techniques, allowing for the modeling of highly complex environments. Secondly, we introduce a new conceptual framework that helps to comprehend the interplay between resiliency and sustainability in decision-making processes. These two contributions provide valuable insights into understanding complex systems and can aid in designing more resilient and sustainable systems.

2022

Supply Chain Resiliency in the Pharmaceutical Industry – a Simulation-Based Approach

Authors
da Silva, ACT; de Sousa, JP; Marques, CM;

Publication
Proceedings of the International Conference on Industrial Engineering and Operations Management

Abstract

2020

Decision-support challenges in the chemical-pharmaceutical industry: Findings and future research directions

Authors
Marques, CM; Moniz, S; de Sousa, JP; Barbosa Povoa, AP; Reklaitis, G;

Publication
COMPUTERS & CHEMICAL ENGINEERING

Abstract
The chemical-pharmaceutical sector is facing an unprecedented fast-changing environment, with new market and technological trends impacting the companies' operational strategies. Managing the pharmaceutical supply chain (PSC) operations is, therefore, ever more complex and challenging. The goal of this work is to present a comprehensive overview of the current state of the industry and research developments; and then, to develop a new decision-making reference framework to assist in the creation of optimization-based decision support models. This will be achieved through a multi-perspective analysis that encompasses strategic and tactical planning decision-making, in the current and future business context of the chemical-pharmaceutical industry. The findings reveal a lack of research addressing the most prominent trends currently driving this sector, such as patient centricity or new technological developments, thus highlighting the disruptive nature of the expected changes in a highly conservative industry.

2019

Challenges in Decision-Making Modelling for New Product Development in the Pharmaceutical Industry

Authors
Marques, CM; Moniz, S; de Sousa, JP;

Publication
29TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT B

Abstract
This study presents an assessment of the main research problems addressed in the literature on New Product Development (NPD) and its methodologies, for the pharmaceutical industry. The work is particularly focused on the establishment of an evolutionary perspective of the relevant modelling approaches, and on identifying the main current research challenges, considering the fast-changing business context of the industry. Main findings suggest a generalized misalignment of recent studies with today's technological and market trends, highlighting the need for new modelling strategies.

Supervised
thesis

2022

Assembly Line Balancing with multiple resources

Author
Ana Margarida da Silva Cruz

Institution
UP-FEUP