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About

After a PhD at KU Leuven, Belgium on 3D echocardiography, I have taken the challenge of a postdoctoral position at INESC TEC under the guidance of Aurélio Campilho. My current project is lung nodule detection, segmentation and characterization on chest CT.

My research interests are medical imaging acquisition and processing, machine learning and applied research for improved patient care.

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Publications

2019

Velocities of Naturally Occurring Myocardial Shear Waves Increase With Age and in Cardiac Amyloidosis

Authors
Petrescu, A; Santos, P; Orlowska, M; Pedrosa, J; Bézy, S; Chakraborty, B; Cvijic, M; Dobrovie, M; Delforge, M; D'hooge, J; Voigt, JU;

Publication
JACC: Cardiovascular Imaging

Abstract

2019

Deep Learning for Segmentation using an Open Large-Scale Dataset in 2D Echocardiography

Authors
Leclerc, S; Smistad, E; Pedrosa, J; Ostvik, A; Cervenansky, F; Espinosa, F; Espeland, T; Berg, EAR; Jodoin, PM; Grenier, T; Lartizien, C; Dhooge, J; Lovstakken, L; Bernard, O;

Publication
IEEE Transactions on Medical Imaging

Abstract

2019

Natural shear wave imaging in the human heart: normal values, feasibility and reproducibility

Authors
Santos, P; Petrescu, AM; Pedrosa, JP; Orlowska, M; Komini, V; Voigt, JU; D'Hooge, J;

Publication
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

Abstract

2019

Non-invasive myocardial performance mapping using 3D echocardiographic stress-strain loops

Authors
Pedrosa, J; Duchenne, J; Queiros, S; Degtiarova, G; Gheysens, O; Claus, P; Voigt, JU; D'hooge, J;

Publication
PHYSICS IN MEDICINE AND BIOLOGY

Abstract
Regional contribution to left ventricular (LV) ejection is of much clinical importance but its assessment is notably challenging. While deformation imaging is often used, this does not take into account loading conditions. Recently, a method for intraventricular pressure estimation was proposed, thus allowing for loading conditions to be taken into account in a non-invasive way. In this work, a method for 3D automatic myocardial performance mapping in echocardiography is proposed by performing 3D myocardial segmentation and tracking, thus giving access to local geometry and strain. This is then used to assess local LV stress-strain relationships which can be seen as a measure of local myocardial work. The proposed method was validated against F-18-fluorodeoxyglucose positron emission tomography, the reference method to clinically assess local metabolism. Averaged over all patients, the mean correlation between FDG-PET and the proposed method was 0.67 +/- 0.18. In conclusion, stress-strain loops were, for the first time, estimated from 3D echocardiography and correlated to the clinical gold standard for local metabolism, showing the future potential of real-time 3D echocardiography ( RT3DE) for the assessment of local metabolic activity of the heart.

2019

Interplay of cardiac remodelling and myocardial stiffness in hypertensive heart disease: a shear wave imaging study using high-frame rate echocardiography

Authors
Cvijic, M; Bézy, S; Petrescu, A; Santos, P; Orlowska, M; Chakraborty, B; Duchenne, J; Pedrosa, J; Vanassche, T; D’hooge, J; Voigt, J;

Publication
European Heart Journal - Cardiovascular Imaging

Abstract
Abstract Aims To determine myocardial stiffness by means of measuring the velocity of naturally occurring myocardial shear waves (SWs) at mitral valve closure (MVC) and investigate their changes with myocardial remodelling in patients with hypertensive heart disease. Methods and results Thirty-three treated arterial hypertension (HT) patients with hypertrophic left ventricular (LV) remodelling (59?±?14?years, 55% male) and 26 aged matched healthy controls (55±15?years, 77% male) were included. HT patients were further divided into a concentric remodelling (HT1) group (13 patients) and a concentric hypertrophy (HT2) group (20 patients). LV parasternal long-axis views were acquired with an experimental ultrasound scanner at 1266?±?317 frames per seconds. The SW velocity induced by MVC was measured from myocardial acceleration maps. SW velocities differed significantly between HT patients and controls (5.83?±?1.20 m/s vs. 4.04?±?0.96 m/s; P?<?0.001). In addition, the HT2 group had the highest SW velocities (P?<?0.001), whereas values between controls and the HT1 group were comparable (P?=?0.075). Significant positive correlations were found between SW velocity and LV remodelling (interventricular septum thickness: r?=?0.786, P?<?0.001; LV mass index: r?=?0.761, P?<?0.001). SW velocity normalized for wall stress indicated that myocardial stiffness in the HT2 group was twice as high as in controls (P?<?0.001), whereas values of the HT1 group overlapped with the controls (P?=?1.00). Conclusions SW velocity as measure of myocardial stiffness is higher in HT patients compared with healthy controls, particularly in advanced hypertensive heart disease. Patients with concentric remodelling have still normal myocardial properties whereas patients with concentric hypertrophy show significant stiffening.