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About

Bruno M. P. M. Oliveira is an auxiliary professor at the University of Porto (Portugal) and a researcher of the LIAAD, INESC TEC. He has a degree in Astronomy, a MSc in Applied Mathematics, a PhD in Applied Mathematics and an Habilitation in Clinical Nutrition - Basic Sciences.
His research reaches several Mathematical areas that include Dynamical Systems, Game Theory and Statistics.
Of his particular interest are applications to Nutrition and Food Sciences (in particular to Clinical Nutrition and Food and Nutrition Consumption Sciences), Immunology (in particular modelling T cell and Tregs), Epidemiology and Economy (in particular in Cournot competition and random pairing markets).
He has participated in research projects funded by EU and the Portuguese FCT covering Nutrition and Food Sciences and Mathematics.

Interest
Topics
Details

Details

  • Name

    Bruno Mendes Oliveira
  • Cluster

    Computer Science
  • Role

    Senior Researcher
  • Since

    01st April 2012
001
Publications

2020

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4(+) T Cells and CD4(+) Tregs

Authors
Yusuf, AA; Figueiredo, IP; Afsar, A; Burroughs, NJ; Pinto, AA; Oliveira, BMPM;

Publication
MATHEMATICS

Abstract
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4+ effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability. Here, we present explicit exact formulas that give the relationship between the concentration of T cells, the concentration of Tregs, and the antigenic stimulation of T cells, when the system is at equilibria, stable or unstable. We found a parameter region of bistability, limited by two thresholds of antigenic stimulation of T cells (hysteresis). Moreover, there are values of the slope parameter of the tuning for which an isola-center bifurcation appears, and, for some other values, there is a transcritical bifurcation. We also present time evolutions of the ODE system.

2020

High prevalence of malnutrition in Internal Medicine wards - a multicentre ANUMEDI study

Authors
Marinho, R; Pessoa, A; Lopes, M; Rosinhas, J; Pinho, J; Silveira, J; Amado, A; Silva, S; Oliveira, BMPM; Marinho, A; Jager Wittenaar, H;

Publication
EUROPEAN JOURNAL OF INTERNAL MEDICINE

Abstract
Background: Disease-related malnutrition is a significant problem in hospitalized patients, with high prevalence rates depending on the studied population. Internal Medicine wards are the backbone of the hospital setting. However, prevalence and determinants of malnutrition in these patients remain unclear. We aimed to determine the prevalence of malnutrition in Internal Medicine wards and to identify and characterize malnourished patients. Methods: A cross-sectional observational multicentre study was performed in Internal Medicine wards of 24 Portuguese hospitals during 2017. Demographics, hospital admissions during the previous year, type of admission, primary diagnosis, Charlson comorbidity index, and education level were registered. Malnutrition at admission was assessed using Patient-Generated Subjective Global Assessment (PG-SGA). Demographic characteristics were compared between well-nourished and malnourished patients. Logistic regression analysis was used to identify determinants of malnutrition. Results: 729 participants were included (mean age 74 years, 51% male). Main reason for admission was respiratory disease (32%). Mean Charlson comorbidity index was 5.8 +/- 2.8. Prevalence of malnutrition was 73% (56% moderate/suspected malnutrition and 17% severe malnutrition), and 54% had a critical need for multidisciplinary intervention (PG-SGA score >= 9). No education (odds ratio [OR] 1.88, 95% confidence interval [CI]: 1.16-3.04), hospital admissions during previous year (OR 1.53, 95%CI: 1.05-2.26), and multiple comorbidities (OR 1.22, 95%CI: 1.14-1.32) significantly increased the odds of being malnourished. Conclusions: Prevalence of malnutrition in the Internal Medicine population is very high, with the majority of patients having critical need for multidisciplinary intervention. Low education level, admissions during previous year, and multiple comorbidities increase the odds of being malnourished.

2019

Evolution of body composition of obese patients undergoing bariatric surgery

Authors
Silva, LB; Oliveira, BMPM; Correia, F;

Publication
CLINICAL NUTRITION ESPEN

Abstract
Background & aims: Bariatric surgery is increasingly common in the fight against morbid obesity. However, after this intervention, it is not fully understood the evolution of weight loss and how body composition changes. The objective of this work is to study the evolution after surgery of weight and body composition of obese patients that underwent bariatric surgery. Methods: In this retrospective and prospective study, we studied initially BMI and body composition of obese patients who attended nutritional appointments at Centro Hospitalar Sao Joao E.P.E. We collected personal data and anthropometric measurements between the pre-surgery appointment up to 60 months after surgery. Results: The sample consisted of 793 patients, of which 86.5% were female and 13.5% were male, with a mean age of 43 years (SD = 10.5 years) and mean height of 1.62 m (SD = 0.079 m). Patients undergoing gastric band, sleeve gastrectomy and gastric bypass had, respectively, an initial BMI reduction of 6.3 kg/ m(2), 13.2 kg/m(2) and 15.4 kg/m(2) and an initial fat mass% reduction of 4.4%, 14.3% and 17.3%. On the other hand, they had an initial increase of 3.2%, 10.8% and 12.4% of water%, 1.4%, 3.9% and 4.6% of fat and waterfree mass%, and 1.9%, 7.3% and 8.9% of skeletal muscle mass%, respectively. BMI and fat mass% on average had a large decrease in the first 12 months, increasing slightly from 24 months onwards. The opposite behaviour was observed for water%, fat and water-free mass% and skeletal muscle mass%. Conclusions: Bariatric surgery initially allows a substantial decrease in BMI as well as beneficial changes in the overall body composition of the individuals. Gastric bypass was the method that caused the most changes, followed by sleeve gastrectomy and, finally, gastric band. On average, after 24 months of follow-up, and for all surgical procedures studied, we observed a reversion in BMI and body composition values, showing the difficulties in maintaining weight and fat loss.

2019

The relationship between health self-perception, food consumption and nutritional status among Portuguese older adults

Authors
Babo, M; Poinhos, R; Franchini, B; Afonso, C; Oliveira, BMPM; Vaz de Almeida, MDV;

Publication
European Journal of Clinical Nutrition

Abstract
In Portugal people aged 65 and above will be the populational group with the highest growth rate of the next decades. Healthy ageing constitutes a challenge as not only the number of years lived are essential, but also the quality of life becomes a priority. The aim of this study was to understand the relationship between health self-perception (HSP), food consumption and nutritional status among Portuguese older adults. Four hundred fifty-nine older adults (aged = 65) were interviewed, almost half had a positive HSP. The most significant predictor of HSP was nutritional status, p = 0.005, but independence in shopping had the largest impact on how they compared to others, p < 0.001. Interventions need to focus on factors like nutritional status, independency on Activities of Daily Living, Satisfaction with Food-Related Life and utilize them to modify the negative HSP and attitudes towards ageing and health and maximize the positive aspects of old age. © 2019, Springer Nature Limited.

2019

The National School Feeding Program as a promoter of Food and Nutrition Education actions in Brazilian schools

Authors
Ottoni, IC; Paz Mendes de Oliveira, BMPM; Bandoni, DH;

Publication
MUNDO DA SAUDE

Abstract
The National School Feeding Program - NSFP is the public health policy that guarantees the minimum supply of healthy food and offers space for the construction of healthy eating habits in Brazilian schools. The objective of the present study was to evaluate the presence of Food and Nutrition Education (FNE) actions within the framework of the NSFP to verify its adequacy toward the program's legislation and to investigate which parameters are predictors of running school gardens. This was a cross-sectional observational study using secondary data obtained from the database of the Efficient School Lunch Management Award for the year 2010, with a sample of 749 municipalities in Brazil. A binary logistic regression was performed, considering the running of school gardens as a dependent variable, and the FNE indicators and the demographic variables as independent. The model containing the presence of FNE in the school curriculum was significant (p<0.001). The presence of FNE in school curricula OR=2.406;95%CI=[1.725, 3.357] was the most significant predictor of running school gardens, followed by the use of food from family farms OR=2.049;95%CI=[1.477, 2.842] and the carrying out of culinary workshops OR=2.032;95%CI=[1.442; 2.863], considering p<0.05. The presence of FNE in the school curriculum was positively associated with growing vegetable gardens, showing that complex actions that require more resources can be stimulated from simpler measures, and the NSFP as a public health policy is an important tool to promote actions throughout the national territory.

Supervised
thesis

2019

Valor preditivo dos marcadores nutricionais na mortalidade e morbilidade dos doentes em hemodiálise

Author
Rosária Maria Afonso Rodrigues de Melo

Institution
UP-FCNAUP

2019

Evolução da densidade mineral óssea em doentes submetidos a cirurgia bariátrica

Author
Beatriz Isabel Guimarães Pereira

Institution
UP-FCNAUP

2019

Défices nutricionais em doentes submetidos a cirurgia bariátrica: relevância da suplementação

Author
Mariana Ferreira e Silva dos Santos Lopes

Institution
UP-FCNAUP

2019

Hábitos Alimentares e Estado Nutricional em Centenários

Author
Juliana Soares Batista

Institution
UP-FCNAUP

2019

Avaliação da Composição Corporal em doentes obesos submetidos a Cirurgia Bariátrica de Revisão

Author
Tiago de Castro Ferreira Neto

Institution
UP-FCNAUP