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About

Bruno M. P. M. Oliveira is an auxiliary professor at the University of Porto (Portugal) and a researcher of the LIAAD, INESC TEC. He has a degree in Astronomy, a MSc in Applied Mathematics, a PhD in Applied Mathematics and an Habilitation in Clinical Nutrition - Basic Sciences.
His research reaches several Mathematical areas that include Dynamical Systems, Game Theory and Statistics.
Of his particular interest are applications to Nutrition and Food Sciences (in particular to Clinical Nutrition and Food and Nutrition Consumption Sciences), Immunology (in particular modelling T cell and Tregs), Epidemiology and Economy (in particular in Cournot competition and random pairing markets).
He has participated in research projects funded by EU and the Portuguese FCT covering Nutrition and Food Sciences and Mathematics.

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Details

Details

  • Name

    Bruno Mendes Oliveira
  • Cluster

    Computer Science
  • Role

    Senior Researcher
  • Since

    01st April 2012
001
Publications

2021

FOREWORD: SPECIAL ISSUE "EURO 2019: GAMES IN ECONOMICS, FINANCE AND BIOLOGY"

Authors
Daniele, P; Fulga, C; Martn Herran, G; Mazalov, V; Petrosyan, L; Oliveira, BMPM; Ramos, C; Weber, GW; Zenkevich, N;

Publication
JOURNAL OF DYNAMICS AND GAMES

Abstract

2021

Prevalence of Nutritional Risk at Admission in Internal Medicine Wards in Portugal: The Multicentre Cross-Sectional ANUMEDI Study

Authors
Marinho, R; Pessoa, A; Lopes, M; Rosinhas, J; Pinho, J; Silveira, J; Amado, A; Silva, S; Oliveira, B; Marinho, A; Jager Wittenaar, H;

Publication
ACTA MEDICA PORTUGUESA

Abstract
Introduction: Disease-related undernutrition is highly prevalent and requires timely intervention. However, identifying undernutrition often relies on physician judgment. As Internal Medicine wards are the backbone of the hospital setting, insight into the prevalence of nutritional risk in this population is essential. We aimed to determine the prevalence of nutritional risk in Internal Medicine wards, to identify its correlates, and to assess the agreement between the physicians' impression of nutritional risk and evaluation by Nutritional Risk Screening 2002. Material and Methods: A cross-sectional multicentre study was performed in Internal Medicine wards of 24 Portuguese hospitals during 2017. Data on demographics, previous hospital admissions, primary diagnosis, and Charlson comorbidity index score were collected. Nutritional risk at admission was assessed using Nutritional Risk Screening 2002. Agreement between physicians' impression of nutritional risk and Nutritional Risk Screening 2002 was tested by Cohen's kappa. Results: The study included 729 participants (mean age 74 +/- 14.6 years, 51% male). The main reason for admission was respiratory disease. Mean Charlson comorbidity index score was 5.8 +/- 2.8. Prevalence of nutritional risk was 51%. Nutritional risk was associated with admission during the previous year (odds ratio = 1.65, 95% confidence interval: 1.22 - 2.24), solid tumour with metastasis (odds ratio = 4.73, 95% confidence interval: 2.06 - 10.87), any tumour without metastasis (odds ratio = 2.04, 95% confidence interval:1.24 - 3.34), kidney disease (odds ratio = 1.83, 95% confidence interval: 1.21 - 2.75), peptic ulcer (odds ratio = 2.17, 95% confidence interval: 1.10 - 4.25), heart failure (odds ratio = 1.51, 95% confidence interval: 1.11 - 2.04), dementia (odds ratio = 3.02, 95% confidence interval: 1.96 - 4.64), and cerebrovascular disease (odds ratio = 1.62, 95% confidence interval: 1.12 - 2.35). Agreement between physicians' evaluation of nutritional status and Nutritional Risk Screening 2002 was weak (Cohen's kappa = 0.415, p < 0.001). Discussion: Prevalence of nutritional risk in the Internal Medicine population is very high. Admission during the previous year and multiple comorbidities increase the odds of being at-risk. Subjective physician evaluation is not appropriate for nutritional screening. Conclusion: The high prevalence of at-risk patients and poor subjective physician evaluation suggest the need to implement mandatory nutritional screening.

2020

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4(+) T Cells and CD4(+) Tregs

Authors
Yusuf, AA; Figueiredo, IP; Afsar, A; Burroughs, NJ; Pinto, AA; Oliveira, BMPM;

Publication
MATHEMATICS

Abstract
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4+ effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability. Here, we present explicit exact formulas that give the relationship between the concentration of T cells, the concentration of Tregs, and the antigenic stimulation of T cells, when the system is at equilibria, stable or unstable. We found a parameter region of bistability, limited by two thresholds of antigenic stimulation of T cells (hysteresis). Moreover, there are values of the slope parameter of the tuning for which an isola-center bifurcation appears, and, for some other values, there is a transcritical bifurcation. We also present time evolutions of the ODE system.

2020

High prevalence of malnutrition in Internal Medicine wards - a multicentre ANUMEDI study

Authors
Marinho, R; Pessoa, A; Lopes, M; Rosinhas, J; Pinho, J; Silveira, J; Amado, A; Silva, S; Oliveira, BMPM; Marinho, A; Jager Wittenaar, H;

Publication
EUROPEAN JOURNAL OF INTERNAL MEDICINE

Abstract
Background: Disease-related malnutrition is a significant problem in hospitalized patients, with high prevalence rates depending on the studied population. Internal Medicine wards are the backbone of the hospital setting. However, prevalence and determinants of malnutrition in these patients remain unclear. We aimed to determine the prevalence of malnutrition in Internal Medicine wards and to identify and characterize malnourished patients. Methods: A cross-sectional observational multicentre study was performed in Internal Medicine wards of 24 Portuguese hospitals during 2017. Demographics, hospital admissions during the previous year, type of admission, primary diagnosis, Charlson comorbidity index, and education level were registered. Malnutrition at admission was assessed using Patient-Generated Subjective Global Assessment (PG-SGA). Demographic characteristics were compared between well-nourished and malnourished patients. Logistic regression analysis was used to identify determinants of malnutrition. Results: 729 participants were included (mean age 74 years, 51% male). Main reason for admission was respiratory disease (32%). Mean Charlson comorbidity index was 5.8 +/- 2.8. Prevalence of malnutrition was 73% (56% moderate/suspected malnutrition and 17% severe malnutrition), and 54% had a critical need for multidisciplinary intervention (PG-SGA score >= 9). No education (odds ratio [OR] 1.88, 95% confidence interval [CI]: 1.16-3.04), hospital admissions during previous year (OR 1.53, 95%CI: 1.05-2.26), and multiple comorbidities (OR 1.22, 95%CI: 1.14-1.32) significantly increased the odds of being malnourished. Conclusions: Prevalence of malnutrition in the Internal Medicine population is very high, with the majority of patients having critical need for multidisciplinary intervention. Low education level, admissions during previous year, and multiple comorbidities increase the odds of being malnourished.

2020

BMI, waist-to-height ratio and body fat mass in older adults: results from the Pronutrisenior project

Authors
Correia, F; Oliveira, BMPM; Poinhos, R; Sorokina, A; Afonso, C; Franchini, B; Pereira, B; Fonseca, L; Sousa, M; Monteiro, A; Vaz de Almeida, MDV;

Publication
PROCEEDINGS OF THE NUTRITION SOCIETY

Abstract
AbstractNear 20% of the Portuguese population is aged 65 years or above, a value similar to most developed countries. This older adult population also suffers from obesity and obesity-related pathologies. The environment encompasses a set of obesity determinants and knowing the associations between the environment and obesity may help health professionals and caregivers to provide for the older adults.In this study, we aimed to relate anthropometric measures with socio-demographic data in older adults.This is a cross-sectional study using data from the Pronutrisenior project, collected in Vila Nova de Gaia, Portugal. The sample consists of 456 older adults, aged 65 to 92 years without cognitive impairment. The sample consisted of older adults living at their homes. Socio-demographic, clinical, geographical, and anthropometric data was collected. The statistical analysis used IBM-SPSS-22.0 and consisted on descriptive statistics, Pearson correlations and UniANOVA. Significantly results (p < 0.05) are reported.These older adults were mostly females (54.2%) with a mean age of 73.8 years (sd = 6.3), mean body mass index (BMI) of 29.1kg/m2 (sd = 4.8), mean waist-to-height ratio (WHtR) of 0.623 (sd = 0.073) and mean percentage of body fat mass (%BFM) of 40.7% (sd = 8.9%) for females and 30.2% (sd = 8.5%) for males. BMI, WHtR and %BFM were positively correlated. In this sample of older adults, higher values of these measures were associated to being female, younger, less educated; to having articular pains and respiratory problems, and not having insomnia, hypertension, chewing problems nor hearing problems; to drink more liquids but not consuming dairy products daily; to not take nutritional supplements but to take more medicines; to be without somebody to talk to and to be more dependent; and to live in a house without stairs to climb and to live near other older adults, and in a more urbanized area with streets with steeper slopes.In this sample of older adults, obesity is related with health characteristics and those are related with socio-demographic and geographical characteristics of the area of residence. Besides the identification of risk factors for the older adult population, this information may help designing health care policies that takes in consideration the physical and geographical characteristics of the neighbourhood of the area of residence of the older adults.

Supervised
thesis

2020

Valor preditivo dos marcadores nutricionais na mortalidade e morbilidade dos doentes em Hemodiálise.

Author
Rosária Maria Afonso Rodrigues de Melo

Institution
UP-FCNAUP

2020

Avaliação do impacto da ingestão de proteína na glicemia pós-prandial em indivíduos adultos com Diabetes Mellitus tipo I com insulinoterapia funcional

Author
Lisandra Marina Baptista Ribeiro

Institution
UP-FCNAUP

2020

Hábitos alimentares e estado de saúde numa população idosa da Região Autónoma da Madeira.

Author
Sara Gomes Müller Pereira

Institution
UP-FCNAUP

2019

Evolução da densidade mineral óssea em doentes submetidos a cirurgia bariátrica

Author
Beatriz Isabel Guimarães Pereira

Institution
UP-FCNAUP

2019

Défices nutricionais em doentes submetidos a cirurgia bariátrica: relevância da suplementação

Author
Mariana Ferreira e Silva dos Santos Lopes

Institution
UP-FCNAUP