Abstract
The gold standard real-time core temperature (CT) monitoring methods are invasive and cost-inefficient. The application of the Kalman filter for an indirect estimation of CT has been explored in the literature for more than 10 years. This paper presents a comparative study between different state-of-the-art Extended Kalman Filter (EKF) approaches. Moreover, we proposed the addition of an extra layer to the pipeline that applies a pre-emptive mapping concept based on the physiological response of the heart rate (HR) signal, before using it as input to the EKF. The algorithm was trained and tested using two datasets (18 subjects). The best-performing approach with the novel pre-emptive mapping achieved an average Root Mean Squared Error (RMSE) of 0.34 ^?C, while without pre-emptive mapping, it resulted in an RMSE of 0.41 ^?C, leading to a performance improvement of 17%. Given these favorable outcomes, it is compelling to assess the efficacy of this method on a larger dataset in the future.

Abstract
Parkinson's Disease (PD) is a neurodegenerative disease characterized by severe motor symptoms, with no cure to date, and deep brain stimulation (DBS) is one of the most effective therapies to reduce the symptoms. However, not all patients benefit equally of this therapy due to adverse effects caused by the stimulation of unwanted areas, making it essential to use diverse technologies when analysing the effect of the DBS in PD. Wearable devices, such as the iHandU System that analyses motor data combined with the Percept TM PC neurostimulator, capable of recording brain signals in real time, allow a more precise, personalized, and adaptive approach to treatment. While each method alone provides valuable but limited insights, combining and synchronizing data from the different sources enables a more comprehensive and dynamic understanding of the effects of stimulation on the patient. A study with 6 DBS-implanted participants from Centro Hospitalar Universitario de São João was conducted to test a synchronization protocol using both the Percept TM PC and the iHandU System. The protocol combined the Network Time Protocol and the Artifact-Based Synchronization Techniques, with an average of less than 500 ms of delay between signals. The results obtained show that this combination improves signal synchronization accuracy and consistency across subjects, minimizing delays and reducing reliance on visible peaks in cases of low signal quality or inconsistent artifact detection. © 2025 IEEE.

Abstract
Artificial Intelligence (AI) is transforming every aspect of modern society. It demonstrates a high potential to contribute to more flexible operations of safety-critical network infrastructures under deep transformation to tackle global challenges, such as climate change, energy transition, efficiency, and digital transformation, including increasing infrastructure resilience to natural and human-made hazards. The widespread adoption of AI creates the conditions for a new and inevitable interaction between humans and AI-based decision systems. In such a scenario, creating an ecosystem in which humans and AI interact healthily, where the roles and positions of both actors are well-defined, is a critical challenge for research and industry in the coming years. This perspective article outlines the challenges and requirements for effective human-AI interaction by taking an interdisciplinary point of view that merges computer science, decision-making sciences, psychological constructs, and industrial practices. The work focuses on three emblematic safety-critical scenarios from two different domains: energy (power grids) and mobility (railway networks and air traffic management).

Abstract
Parkinson's Disease (PD) is a neurological disease that progresses over time and causes severe motor symptoms. Therefore, treating PD requires constant patient monitoring, which may turn clinical practice overwhelming, preventing its practical implementation, and raising the need for patient monitoring outside the clinical setting. The iHandU system described in this paper fulfils this need by providing an objective way to quantify motor symptoms of PD in non-clinical settings. It integrates an innovative real-time assessment of the severity of motor symptoms based on signal processing and Machine Learning models that mimic the clinical severity classification scales used in practice and allows for a more continuous and personalized therapy planning and management by doctors, through the use of a web dashboard user-friendly interface. This system, recently tested at 5 patients' homes, has shown promising results as a PD patient management digital platform, reaching a usability score of 83.9% (A grade) based on the System Usability Scale (SUS). Such a level shows a strong alignment between user needs, expectations and functionalities. This study highlights the potential of the used system as a Patient Management Tool showing a case study from an ongoing clinical study. By giving additional information to the doctors with features beyond the semi-quantitative rating scales currently used, allowing a more optimized and continuous PD symptom management, it will be possible to advance PD management further.

Abstract
The progressive and complex nature of Parkinson's disease (PD) may largely benefit from regular and personalised monitoring, which is beyond the current clinical practice and routinely available systems. This paper proposes a simple and effective system to address this issue by using a wearable device to quantify a key PD's motor symptom - gait impairment as a proof-of-concept for a future broader approach. In this study, 60 inertial signals were collected from the ankle in 41 PD patients during a clinical standard gait assessment exercise. Each exercise iteration was classified by a specialised neurologist based on the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). A signal processing and feature extraction pipeline was employed to characterise gait, followed by a statistical analysis of their ability to differentiate between the 5 levels of impairment. The results revealed that 4 of the 8 studied features exhibited high discriminatory power between different severity levels of gait impairment, with statistical significance. The distinguishing capability of these 4 extracted features - gait consistency, rotation angle, mean height and length of steps - holds great promise for the development of a gait severity quantification remote monitoring for PD patients at home or on the move, proving the concept of the usefulness of wearable devices for regular and personalised PD symptom monitoring.