Abstract

Abstract
The aim of this work is to give an overview on the development of theoretical concepts and methodological approaches to investigate innovation networks, in particular the use of social network analysis in the study of university industry relations. The structure of networks can be analysed through the lens of Social Network Analysis. This methodological approach is described and its fundamental concepts are presented. The paper then reviews the applications of this approach on the study of university industry relations. These relations can be considered as an innovation network, in the sense that the interactions established by its participants have more or less defined innovation goals. Different structures in the relations may result in different innovation outcomes, and the use of SNA may be particularly useful to understand differential outcomes. It is thus important to take stock of the knowledge concerning the efforts that have been made to probe the complex phenomena of university industry relations and, in particular, how approaches based on social network analysis have been used to understand it. This work is based on a review of available literature on the topics. The paper aims at systematizing the information and knowledge related to the application of SNA on university industry networks, highlighting the main research pathways, the main conclusions and pointing possible future research questions.

Abstract
An increase of fracture incidence is expected for the next decades, mostly due to the undeniable increase of osteoporotic fractures, associated with the rapid population ageing. The rise in sports-related fractures affecting the young and active population also contributes to this increased fracture incidence, and further amplifies the economical burden of fractures. Fracture often results in severe pain, which is a primary symptom to be treated, not only to guarantee individual's wellbeing, but also because an efficient management of fracture pain is mandatory to ensure proper bone healing. Here, we review the available data on bone innervation and its response to fracture, and discuss putative mechanisms of fracture pain signaling. In addition, the common therapeutic approaches to treat fracture pain are discussed. Although there is still much to learn, research in fracture pain has allowed an initial insight into the mechanisms involved. During the inflammatory response to fracture, several mediators are released and will putatively activate and sensitize primary sensory neurons, in parallel, intense nerve sprouting that occurs in the fracture callus area is also suggested to be involved in pain signaling. The establishment of hyperalgesia and allodynia after fracture indicates the development of peripheral and central sensitization, still, the underlying mechanisms are largely unknown. A major concern during the treatment of fracture pain needs to be the preservation of proper bone healing. However, the most common therapeutic agents, NSAIDS and opiates, can cause significant side effects that include fracture repair impairment. The understanding of the mechanisms of fracture pain signaling will allow the development of mechanisms-based therapies to effectively and safely manage fracture pain.

Abstract
The Internet offers a set of information that is constantly growing in both size and complexity, becoming an indispensable tool to our daily-lifes. A particular group of Web users are those with some sort of disabilities or incapacities. These users need this technology to be adaptable to their incapacities and limitations, thus the need fo the entities behind their development assume the inherent responsabilities. This document serves as a summary of a research project aimed at studying the relation between the users needs and the perspectives on the topic presented by the companies behind Web content development, thus characterizing this reality and achieve future adjustments.

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Abstract
Objectives: To understand and build a collective vision of all existing institutions in the Portuguese National Health Service as well as to perceive how and how far the interaction between those multiple institutions is supported by Information Systems (IS). Methods: Upon identification of the institutions involved in the healthcare process, a set of interviews with experienced people from those institutions was conducted, which produced about five hours of tape. The research was focused exclusively on processes involving two different organizations and any internal processes were altogether excluded from it. Results: The study allowed the identification of about 50 recurrent interaction processes, which were classified into four different varieties in accordance with the nature of the information flow: administrative, clinical, identificational and statistical. In addition, these processes were divided in accordance with the way how that integration is achieved, from completely automated to email or telephone-based. Conclusions: Funds/Money related processes are technologically more rigid and standardized, whereas auditing and inspection ones are less supported by automatic systems. There emerged an interesting level of sharing and integration in clinical processes, although the integration is mostly made at the interface level. The authors identified 5 particularly relevant and dominant actors (2 classes of individuals and 3 institutions) with which there is a need for coordination and cooperation. The authors consider that, in future works, an effort should be made to provide the various institutions with guidelines/interfaces and prompt such institutions to elaborate upon these.