Abstract
The European rabbit (Oryctolagus cuniculus) was the first animal model used to understand human diseases like rabies and syphilis. Nowadays, the rabbit is still used to study several human infectious diseases like syphilis, HIV and papillomavirus. However, due to several mainly practical reasons, it has been replaced as an animal model by mice (Mus musculus). The rabbit and mouse share a recent common ancestor and are classified in the superorder Glires which arose at approximately 82 million years ago (mya). These species diverged from the Primates' ancestor at around 92 million years ago and, as such, one expects the rabbit-human and mouse-human genetic distances to be very similar. To evaluate this hypothesis, we developed a set of tools for automatic data extraction, sequence alignment and similarity study, and a web application for visualization of the resulting data. We aligned and calculated the genetic distances for 2793 innate immune system genes from human, rabbit and mouse using sequences available in the NCBI database. The obtained results show that the rabbit-human genetic distance is lower than the mouse-human genetic distance for 88% of these genes. Furthermore, when we considered only genes with a difference in genetic distance higher than 0.05, this figure increase to 93%. These results can be explained by the increase of the mutation rates in the mouse lineage suggested by some authors and clearly show that, at least looking to the genetic distance to human genes, the European rabbit is a better model to study innate immune system genes than the mouse.

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In this paper, a multi-temporal optimal power flow (OPF) model for radial networks is proposed. The mathematical problem formulation is presented as a mixedinteger quadratically constrained programming (MIQCP) problem. The main core of the developed OPF problem is benefiting from the second-order conic programming (SOCP) approach while the quadratic constraints of the power flow equations have been efficiently handled. In the developed model, the dynamic behaviour of the electrical energy storage (EES) has been addressed for the day-ahead operation problem. In addition, the developed model is tested and verified for both normal and contingent events and the obtained results are satisfactory in terms of feasibility and optimality. In the islanded operation, a grid-forming unit is the main responsible for maintaining the voltage reference while other units behave as slave. The model is tested on the modified IEEE 33-bus network to verify the performance of the developed tool.

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We present a literature review that aims to understand the role of the Educational Escape Room (EER) in improving the teaching, learning, and assessment processes through an EER design framework. The main subject is to identify the recent interventions in this field in the last five years. Our study focuses on understanding how it is possible to create an EER available to all students, namely visually challenged users. As a result of the implementation of new learning strategies that promote autonomous learning, a concern arose in adapting educational activities to each student's individual needs. To study the adaptability of each EER, we found the EER design framework essential to increase the student experience by promoting the consolidation of knowledge through narrative and level design. The results of our study show evidence of progress in students' performance while playing an EER, revealing that students' learning can be effective. Research on Procedural Content Generation (PCG) highlighted how important it is to implement adaptability in future studies of EERs. However, we found some limitations regarding the process of evaluating learning through the EERs, showing how important it is to study and implement learning analytics in future studies in this field.

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This paper presents an educational resource to support the teaching of Portuguese sign language. This educational resource emerges in response to the significant needs for the development of adequate digital tools to support deaf people in different tasks, especially in the language learning process. This work is motivated by the results and conclusions from previous studies that identify augmented reality as one of the promising solutions to improve the learning and teaching processes, and benefits from the advances already accomplished in the development and application of augmented reality solutions in several domains of the educational environment. The educational resource presented in this work is an augmented reality solution that enables associating hand gestures, representative of Portuguese sign language, to different cards, which represent different letters of the alphabet. In this way, it is possible to associate the alphabet letters with the respective gestures in a visual and straightforward way, facilitating the learning process.