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According to the World Health Organization forecast, over 55 million people worldwide have dementia, and about 10 million new cases are detected yearly. Early diagnosis is essential for patients to plan for the future and deal with the disease. Machine Learning algorithms allow us to solve the problems associated with early disease detection. This work attempts to identify the current relevance of the application of machine learning in dementia prediction in the scientific world and suggests open fields for future research. The literature review was conducted by combining bibliometric and content analysis of articles originating in a period of 20 years in the Scopus database. Twenty-seven thousand five hundred twenty papers were identified firstly, of which a limited number focused on machine learning in dementia diagnosis. After the exclusion process, 202 were selected, and 25 were chosen for analysis. The recent increasing interest in the past five years in the theme of machine learning in dementia shows that it is a relevant field for research with still open questions. The methods used to identify dementia or what features are used to identify or predict this disease are explored in this study. The literature review revealed that most studies used magnetic resonance imaging (MRI) and its types as the main feature, accompanied by demographic data such as age, gender, and the mini-mental state examination score (MMSE). Data are usually acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Classification of Alzheimer's disease is more prevalent than prediction of Mild Cognitive Impairment (MCI) or their combination. The authors preferred machine learning algorithms such as SVM, Ensemble methods, and CNN because of their excellent performance and results in previous studies. However, most use not one machine-learning technique but a combination of techniques. Despite achieving good results in the studies considered, there are new concepts for future investigation declared by the authors and suggestions for improvements by employing promising methods with potentially significant results.

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Peripheral arterial disease (PAD) causes blockage of the arteries, altering the blood flow to the lower limbs. This blockage can cause the individual with PAD to feel severe pain in the lower limbs. The main contribution of this research is the discovery of a solution that allows the automatic detection of the onset of claudication based on data analysis from patients' smartphones. For the data-collection procedure, 40 patients were asked to walk with a smartphone on a thirty-meter path, back and forth, for six minutes. Each patient conducted the test twice on two different days. Several machine learning models were compared to detect the onset of claudication on two different datasets. The results suggest that we can identify the onset of claudication using inertial sensors with a best case accuracy of 92.25% for the Extreme Gradient Boosting model.

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