Abstract

Abstract
The concept of circular economy aims to extend the end-of-life of products by reducing or reusing products and materials, being Design a central part of a successful circular product. In line with the 6Rs strategy for circularity, Redesign (applied by eco-design practices) allows the creation of products that can be easily repaired, upgraded, or disassembled, extending their life, and fomenting a circular economy. For that reason, the aim of this research is to analyse the role of Redesign in the circularity of footwear products. Exploratory qualitative research was conducted, with five in-depth interviews with founders and R&D managers of prominent footwear organizations. Results demonstrate that most interviewed companies, which were born circular, considered Redesign practices from the definition of the product concept. In conclusion, looking at Redesign strategies holistically and through its specific sub-relationships have a major impact on the company's circularity practises.

Abstract
The purpose of this study is to ascertain the hierarchical importance of a patent's characteristics to licensing. This research has a causal-exploratory purpose, in that it sought to establish relationships between variables. This research aims to identify which characteristics are influential in the licensing of Brazilian academic patents in the biotechnology and pharmaceutical technology fields, based on the mining of data contained in licensed and unlicensed patent documents. Which characteristics of Brazilian academic patents are most influential in their licensing potential? An analysis through Random Forest was performed. To the best of our knowledge, there are no studies in Brazil using machine learning to identify which characteristics are influential in licensing a particular academic patent, especially given the difficulty of gathering this information. We found that regardless of the measure used, the three most critical licensing characteristics for the Biotechnology and Pharmaceutical patents analysed are Patent Scope, Life Cycle, and Claims. At the same time, the least important is the Patent Cooperation Treaty. The relevance of this research is based on the fact that after identifying which intrinsic characteristics influence the final value and licensing probabilities of a given patent, it will be possible to develop mathematical models that provide accurate information for establishing technology transfer agreements. In practical terms, the results suggest that greater patent versatility, combined with lifecycle management and a technical effort to build strong claims, increases the licensing potential of academic biopharmaceutical patents.

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Abstract
This study reflects the assumption that all links in a supply chain (SC) must share responsibility for socio-environmental issues. One of the main barriers to ensuring the sustainability of an SC is the difficulty in accessing partners' information, especially beyond the first tier. Due to the great geographical dispersion, large number of small companies, and, mainly, the growth of the fast fashion industry, the textile sector is recognised as a priority when it comes to social sustainability issues. Moreover, consumers are increasingly demanding information about the social footprint of products. Thus, this paper aims to contribute to a better understanding of how SC visibility can contribute to increasing the social sustainability of textile SCs. Using a longitudinal perspective and adopting mixed methods integrated into a design science strategy, we evaluate SC visibility in the context of two Portuguese textile supply chains, before and after the development of a technology-based solution.

Abstract
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by hyperglycemia, which can affect metabolic, vascular, and hematological parameters. A low-carbohydrate, high-fat (LCHF) diet has been shown to improve glycemic control and blood pressure regulation. Exercise in hypoxia (EH) enhances insulin sensitivity, erythropoiesis, and angiogenesis. The combination of LCHF and EH may offer a promising strategy for managing T2DM and hypertension (HTN), although evidence remains limited. This study aimed to assess the effects of an eight-week normobaric EH intervention at 3000 m simulated altitude combined with an LCHF diet on hematological and lipid profiles, inflammation, and blood pressure in older patients with T2DM and HTN. Methods: Forty-two diabetic patients with HTN were randomly assigned to three groups: (1) control group (control diet + exercise in normoxia), (2) EH group (control diet + EH), and (3) intervention group (EH+LCHF) Baseline and eight-week measurements included systolic, diastolic, and mean blood pressure (SBP, DBP, MAP), hematological and lipid profiles, and inflammation biomarkers. Results: Blood pressure decreased after the intervention (p < 0.001), with no significant differences between groups (SBP: p = 0.151; DBP: p = 0.124; MAP: p = 0.18). No differences were observed in lipid profile or C-reactive protein levels (p > 0.05). Mean corpuscular hemoglobin (MCH) increased in the EH group (p = 0.027), while it decreased in the EH+LCHF group (p = 0.046). Conclusions: Adding hypoxia or restricting carbohydrates did not provide additional benefits on blood pressure in T2DM patients with HTN. Further elucidation of the mechanisms underlying hematological adaptations is imperative.