Abstract
Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying transcriptional profile is still poorly understood. We have performed deep RNA sequencing in different subpopulations of normal B-lymphocytes and CLL cells from a cohort of 98 patients, and characterized the CLL transcriptional landscape with unprecedented resolution. We detected thousands of transcriptional elements differentially expressed between the CLL and normal B cells, including protein-coding genes, noncoding RNAs, and pseudogenes. Transposable elements are globally derepressed in CLL cells. In addition, two thousand genes-most of which are not differentially expressed-exhibit CLL-specific splicing patterns. Genes involved in metabolic pathways showed higher expression in CLL, while genes related to spliceosome, proteasome, and ribosome were among the most down-regulated in CLL. Clustering of the CLL samples according to RNA-seq derived gene expression levels unveiled two robust molecular subgroups, C1 and C2. C1/C2 subgroups and the mutational status of the immunoglobulin heavy variable (IGHV ) region were the only independent variables in predicting time to treatment in a multivariate analysis with main clinico-biological features. This subdivision was validated in an independent cohort of patients monitored through DNA microarrays. Further analysis shows that B-cell receptor (BCR) activation in the microenvironment of the lymph node may be at the origin of the C1/C2 differences. © 2014 Hansen et al.

Abstract
This paper studies the impact of the energy upon electricity markets using Multidimensional Scaling (MDS). Data from major energy and electricity markets is considered. Several maps produced by MDS are presented and discussed revealing that this method is useful for understanding the correlation between them. Furthermore, theresults help electricity markets agents hedging against Market Clearing Price (MCP) volatility. © Springer Science+Business Media Dordrecht 2014.

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Abstract

Abstract
In this paper the role of Plug-In Electric Vehicles' (PIEVs) parking lot in operating Smart Multi-Energy System (SMES) has been investigated. SMES in this paper has been modeled as a multi-input multi-output model which consists of some storage and energy converters. In the proposed framework, the PIEV's parking lot behaves like an energy storage with selling energy price less than upstream network price and as manageable load when its purchase price is more than upstream network. On the other hand, traffic pattern of PIEVs in parking lot has an uncertain behavior and is modeled based on stochastic approach. In the stochastic model, two branches of scenarios for total state of charge and total capacity of parking lot in each hour are produced. The considered case studies show the effectiveness of the proposed model and the impact of PIEVs' parking lot in operation of SMES elements.

Abstract
Within network measurement context, traffic sampling has been targeted as a promising solution to cope with the huge amount of traffic traversing network devices as only a subset of packets is elected for analysis. Although this brings an evident advantage to measurement overhead, the computational burden of performing sampling tasks in network equipment may overshadow the potential benefits of sampling. Attending that sampling techniques evince distinct temporal and spatial characteristics in handling traffic, this paper is focused on studying the computational weight of current and emerging techniques in terms of memory consumption, CPU load and data volume. Furthermore, the accuracy of these techniques in estimating network parameters such as throughput is evaluated. A sampling framework has also been implemented in order to provide a versatile and fair platform for carrying out the testing and comparison process.