Cookies
O website necessita de alguns cookies e outros recursos semelhantes para funcionar. Caso o permita, o INESC TEC irá utilizar cookies para recolher dados sobre as suas visitas, contribuindo, assim, para estatísticas agregadas que permitem melhorar o nosso serviço. Ver mais
Aceitar Rejeitar
  • Menu
Publicações

2015

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Autores
Yang J.; Huang T.; Petralia F.; Long Q.; Zhang B.; Argmann C.; Zhao Y.; Mobbs C.V.; Schadt E.E.; Zhu J.; Tu Z.; Ardlie K.G.; Deluca D.S.; Segrè A.V.; Sullivan T.J.; Young T.R.; Gelfand E.T.; Trowbridge C.A.; Maller J.B.; Tukiainen T.; Lek M.; Ward L.D.; Kheradpour P.; Iriarte B.; Meng Y.; Palmer C.D.; Winckler W.; Hirschhorn J.; Kellis M.; MacArthur D.G.; Getz G.; Shablin A.A.; Li G.; Zhou Y.H.; Nobel A.B.; Rusyn I.; Wright F.A.; Lappalainen T.; Ferreira P.G.; Ongen H.; Rivas M.A.; Battle A.; Mostafavi S.; Monlong J.; Sammeth M.; Mele M.; Reverter F.; Goldman J.; Koller D.; Guigo R.; McCarthy M.I.; Dermitzakis E.T.; Gamazon E.R.; Konkashbaev A.; Nicolae D.L.; Cox N.J.; Flutre T.; Wen X.; Stephens M.; Pritchard J.K.; Lin L.; Liu J.; Brown A.; Mestichelli B.; Tidwell D.; Lo E.; Salvatore M.; Shad S.; Thomas J.A.; Lonsdale J.T.; Choi C.; Karasik E.; Ramsey K.; Moser M.T.; Foster B.A.; Gillard B.M.; Syron J.; Fleming J.; Magazine H.; Hasz R.; Walters G.D.; Bridge J.P.; Miklos M.; Sullivan S.; Barker L.K.; Traino H.; Mosavel M.; Siminoff L.A.; Valley D.R.; Rohrer D.C.; Jewel S.; Branton P.; Sobin L.H.; Qi L.; Hariharan P.; Wu S.; Tabor D.; Shive C.; Smith A.M.; Buia S.A.;

Publicação
Scientific Reports

Abstract
Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.

2015

Comparison of Battery Models for Energy Storage Applications on Insular Grids

Autores
Rodrigues, EMG; Godina, R; Osorio, GJ; Lujano Rojas, JM; Matias, JCO; Catalao, JPS;

Publicação
2015 AUSTRALASIAN UNIVERSITIES POWER ENGINEERING CONFERENCE (AUPEC)

Abstract
This paper explores different modelling techniques for representing electrochemical energy storage devices in insular power grid applications. Particular attention is given to Thevenin based and not Thevenin based models. A case study involving two insular power systems with renewable generation are used to stand out the performance of the selected battery technologies: Lithium-ion (Li-ion), Nickel-Cadmium (NiCd), Nickel-Metal Hydride (NiMH) and Lead Acid.

2015

Evaluation of Flexible Demand-Side Load-Following Reserves in Power Systems with High Wind Generation Penetration

Autores
Paterakis, NG; Catalao, JPS; Ntomaris, AV; Erdinc, O;

Publicação
2015 IEEE EINDHOVEN POWERTECH

Abstract
In this study, a two-stage stochastic programming joint energy and reserve day-ahead market structure is proposed in order to procure the required load-following reserves to tackle with wind power production uncertainty. Reserves can be procured both from generation and demand-side. Responsive aggregations of loads, as well as large industrial consumers are considered. The proposed methodology is evaluated through various simulations performed on the insular power grid of Crete, Greece.

2015

An Intelligent Weather Station

Autores
Mestre, G; Ruano, A; Duarte, H; Silva, S; Khosravani, H; Pesteh, S; Ferreira, PM; Horta, R;

Publicação
SENSORS

Abstract
Accurate measurements of global solar radiation, atmospheric temperature and relative humidity, as well as the availability of the predictions of their evolution over time, are important for different areas of applications, such as agriculture, renewable energy and energy management, or thermal comfort in buildings. For this reason, an intelligent, light-weight, self-powered and portable sensor was developed, using a nearest-neighbors (NEN) algorithm and artificial neural network (ANN) models as the time-series predictor mechanisms. The hardware and software design of the implemented prototype are described, as well as the forecasting performance related to the three atmospheric variables, using both approaches, over a prediction horizon of 48-steps-ahead.

2015

Identifying nonconformity root causes using applied knowledge discovery

Autores
Donauer, M; Pecas, P; Azevedo, A;

Publicação
ROBOTICS AND COMPUTER-INTEGRATED MANUFACTURING

Abstract
Quality control, failure analysis and improvement are central elements in manufacturing. Total Quality Management (TQM) provides several quality oriented tools and techniques which, in the event of things, are not always applicable. The increased use of Information Technology (IT) in manufacturing means increased data availability and improved potential for knowledge extraction. Exploiting this knowledge requires data storage and processing facilities with demanding, time consuming sessions for interpretation. Without suitable tools and techniques, knowledge remains hidden in databases. This paper presents a method to help identify root causes of nonconformities (NCs) using a pattern identification approach. Hereby, a general framework, Knowledge Discovery in Databases (KDD), is adapted. This adaptation involves incorporating an economic concentration measure, the Herfindahl-Hirschman Index (HHI), as the data mining algorithm. After presenting the theoretical background, a new methodology is proposed. The suggested approach can be regarded as a quality tool to help make root cause identification of failures simpler and more agile. A case study from the automotive industry is examined using this tool. Results are obtained and presented in the form of matrix based patterns. They suggest that concentration indices help indicate possible root causes of NCs, warranting further investigation in this area.

2015

Learning from evolving video streams in a multi-camera scenario

Autores
Khoshrou, S; Cardoso, JS; Teixeira, LF;

Publicação
MACHINE LEARNING

Abstract
Nowadays, video surveillance systems are taking the first steps toward automation, in order to ease the burden on human resources as well as to avoid human error. As the underlying data distribution and the number of concepts change over time, the conventional learning algorithms fail to provide reliable solutions for this setting. In this paper, we formalize a learning concept suitable for multi-camera video surveillance and propose a learning methodology adapted to that new paradigm. The proposed framework resorts to the universal background model to robustly learn individual object models from small samples and to more effectively detect novel classes. The individual models are incrementally updated in an ensemble-based approach, with older models being progressively forgotten. The framework is designed to detect and label new concepts automatically. The system is also designed to exploit active learning strategies, in order to interact wisely with operator, requesting assistance in the most ambiguous to classify observations. The experimental results obtained both on real and synthetic data sets verify the usefulness of the proposed approach.

  • 2650
  • 4377