Abstract
The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell contained mostly transcripts from one allele from the majority of genes; indeed, 76.4% of the hetSNVs displayed stochastic monoallelic expression in single cells. Remarkably, adjacent hetSNVs exhibited a haplotype-consistent allelic ratio; in contrast, distant sites located in two different genes were independent of the haplotype structure. Moreover, the allele-specific expression in single cells correlated with the abundance of the cellular transcript. We observed that genes expressing both alleles in the majority of the single cells at a given time point were rare and enriched with highly expressed genes. The relative abundance of each allele in a cell was controlled by some regulatory mechanisms given that we observed related single-cell allelic profiles according to genes. Overall, these results have direct implications in cellular phenotypic variability. © 2015 The American Society of Human Genetics.

Abstract
This work presents a new approach to tune the parameters of the discontinuous component of the Sliding Mode Generalized Predictive Controller (SMGPC) subject to constraints. The strategy employs Particle Swarm Optimization (PSO) to minimize a second aggregated cost function. The continuous component is obtained by the standard procedure, by Sequential Quadratic Programming (SQP), thus yielding a dual optimization scheme. Simulations and performance indexes for a non minimum linear model result in a better performance, improving robustness and tracking accuracy.

Abstract
This paper presents a new approach to efficiently search for suitable compiler pass sequences, a challenge known as phase ordering. Our approach relies on information about the relative positions of compiler passes in compiler pass sequences previously generated for a set of functions when compiling for a specific processor. We enhanced two iterative compiler pass exploration schemes, one relying on simple sequential compiler pass insertion and other implementing an auto-tuned simulated annealing process, with a data structure that holds information about the relative positions of compiler sequences; in order to reduce the set of compiler passes considered for insertion in a given position of a given candidate compiler pass sequence to include only the passes that have a higher probability of performing well on that relative position in the compiler sequence, speeding up the exploration time as a result. We tested our approach with two different compilers and two different targets; the ReflectC and the LLVM compilers, targeting a MicroBlaze processor and a LEON3 processor, respectively. The experimental results show that we can considerably reduce the number of algorithm iterations by a factor of up to more than an order of magnitude when targeting the MicroBlaze or the LEON3, while finding compiler sequences that result in binaries that when executed on the target processor/simulator are able to outperform (i.e. use less CPU cycles) all the standard optimization levels (i.e., we compare against the most performing optimization level flag on each kernel, e.g. -O1, -O2 or -O3 in the case of LLVM) by a geometric mean performance improvement of 1.23x and 1.20x when targeting the MicroBlaze processor, and 1.94x and 2.65x when targetting the LEON3 processor; for each of the two exploration algorithms and two kernel sets considered. © 2015 ACM.

Abstract
With the emergence of new low-cost gestural interaction devices various studies have been developed on multi-modal human-computer interaction to improve user experience. We present an exploratory study which analysed the user experience with a multimodal interaction game prototype. As a result, we propose a set of preliminary recommendations for combined use of such devices and present implications for advancing the multimodal field in human-computer interaction.

Abstract
In this paper, a mixed-integer linear programing ( MILP) model for the traffic behavior of plug-in electric vehicles ( PEVs) in an urban environment is proposed. It is assumed that any environment can be categorized into different zones based on their urban functions ( e. g. industrial, residential, and commercial). Therefore, the interaction of PEVs that travel between these zones has to be modeled. Besides, it is assumed that in each zone a parking lot ( PL) and individual charging stations exist to provide the required state of charge ( SOC) for PEVs during their daily travel. As a result, the amount of power that these PEVs consume ( rather in PL or charging stations) and the amount of SOC that PEVs carry with them should be precisely computed. The proposed MILP model is applied on two zones urban area with residential and industrial districts and the numerical results prove the proficiency of the model.

Abstract