Abstract
Continuous assessment of the quality of health-related life (HRQoL) of patients is an important aspect of health and gives rise to several readings. On one hand, the enormous amount of information that is generated allows the extraction of knowledge with great accuracy concerning the disease, the treatments and the impact it has on society, on the other hand, this continuous monitoring allows effective control and one timely intervention on the patient. The QoLIS platform has a set of characteristics advantageous over other, including the wide range of analyses that can be made from the results that it provides. However, the complexity of the calculus evolved on the models used, combined with the number of data processing, hamper its use in real time, hindering their use in the context of a medical appointment. Whereas the use of evaluation of quality of life (QoL) in the context of a appointment is an added value for everyone involved, it was necessary to develop and implement, on the QoLIS, a strategy for determining the value of QoL, by estimate, based on Rasch model (in order to provide the same set of responses) and whose response time allows its effective use

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The aim of this work is to give an overview on the development of theoretical concepts and methodological approaches to investigate innovation networks, in particular the use of social network analysis in the study of university industry relations. The structure of networks can be analysed through the lens of Social Network Analysis. This methodological approach is described and its fundamental concepts are presented. The paper then reviews the applications of this approach on the study of university industry relations. These relations can be considered as an innovation network, in the sense that the interactions established by its participants have more or less defined innovation goals. Different structures in the relations may result in different innovation outcomes, and the use of SNA may be particularly useful to understand differential outcomes. It is thus important to take stock of the knowledge concerning the efforts that have been made to probe the complex phenomena of university industry relations and, in particular, how approaches based on social network analysis have been used to understand it. This work is based on a review of available literature on the topics. The paper aims at systematizing the information and knowledge related to the application of SNA on university industry networks, highlighting the main research pathways, the main conclusions and pointing possible future research questions.

Abstract
An increase of fracture incidence is expected for the next decades, mostly due to the undeniable increase of osteoporotic fractures, associated with the rapid population ageing. The rise in sports-related fractures affecting the young and active population also contributes to this increased fracture incidence, and further amplifies the economical burden of fractures. Fracture often results in severe pain, which is a primary symptom to be treated, not only to guarantee individual's wellbeing, but also because an efficient management of fracture pain is mandatory to ensure proper bone healing. Here, we review the available data on bone innervation and its response to fracture, and discuss putative mechanisms of fracture pain signaling. In addition, the common therapeutic approaches to treat fracture pain are discussed. Although there is still much to learn, research in fracture pain has allowed an initial insight into the mechanisms involved. During the inflammatory response to fracture, several mediators are released and will putatively activate and sensitize primary sensory neurons, in parallel, intense nerve sprouting that occurs in the fracture callus area is also suggested to be involved in pain signaling. The establishment of hyperalgesia and allodynia after fracture indicates the development of peripheral and central sensitization, still, the underlying mechanisms are largely unknown. A major concern during the treatment of fracture pain needs to be the preservation of proper bone healing. However, the most common therapeutic agents, NSAIDS and opiates, can cause significant side effects that include fracture repair impairment. The understanding of the mechanisms of fracture pain signaling will allow the development of mechanisms-based therapies to effectively and safely manage fracture pain.

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The Internet offers a set of information that is constantly growing in both size and complexity, becoming an indispensable tool to our daily-lifes. A particular group of Web users are those with some sort of disabilities or incapacities. These users need this technology to be adaptable to their incapacities and limitations, thus the need fo the entities behind their development assume the inherent responsabilities. This document serves as a summary of a research project aimed at studying the relation between the users needs and the perspectives on the topic presented by the companies behind Web content development, thus characterizing this reality and achieve future adjustments.

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