Abstract
This letter is an enhancement to our previous paper that quantifies additional reinforcement costs (ARCs) for low-voltage assets under moderate degree of three-phase imbalance. The original formulas cause an overestimation of the ARCs under severe imbalance. This letter first quantifies the threshold of the severe degree of imbalance (DIB), below which the original formulas are applicable. Then, the ARC formulas are extended to account for the whole range of DIB. Case studies demonstrate that when the asset loading level is below 33.3% (50%) for a feeder (a transformer), the DIB never exceeds the threshold and the original ARC formulas are applicable; otherwise, the DIB can exceed the threshold and the extended formulas yield correct ARCs.

Abstract
This paper presents an overview of the work under development within MAESTRI EU-funded collaborative project. The MAESTRI Total Efficiency Framework (MTEF) aims to advance the sustainability of manufacturing and process industries by providing a management system in the form of a flexible and scalable platform and methodology. The MTEF is based on four pillars: (a) an effective management system targeted at process continuous improvement; (b) Efficiency assessment tools to support improvements, optimisation strategies and decision support; (c) Industrial Symbiosis paradigm to gain value from waste and energy exchange; (d) an Internet-of-Things infrastructure to support easy integration and data exchange among shop-floor, business systems and tools.

Abstract
Climatic data collected between 1963 and 2010 in the Portuguese Dão wine growing region were analysed to evaluate the relationship between climatic indices, seasonal weather and the berry composition of the red cultivar 'Touriga Nacional'. The trends over time for the classical temperature-based indices (growing season temperature, growing degree days, biologically effective degree days, Huglin index and cool night index) were significantly positive and can be mostly attributed to the effects of climate change. The dryness index showed a negative trend although not significant. These indices were able to explain 9 and 45% of the variability in total soluble solids and titratable acidity, respectively, using a multiple stepwise regression analysis. The proportion of explained variability was much improved, to 52% for total soluble solids and 65% for titratable acidity, when new climatic indices were used. The new indices resulted from the generalisation of the classical indices based upon chronological time specification as well as taking into consideration the phenological time instead. Our data shows that the classical climatic indices were not able to sufficiently explain the berry composition, and that new climatic indices should be used for a better understanding of the climate drivers of berry quality.

Abstract
In the vehicle routing problem with heterogeneous fleet and variable costs (HFVRP), the group of routes to be developed to satisfy the demand of the customer must be determined, considering the minimization of the total costs of the travelled distance. Heuristic algorithms based on local searches use simple movements (neighborhoods) to generate feasible solutions to problems related to route design. In this article, we conduct a comparative analysis of granular neighborhoods in a Tabu Search for the HFVRP, in terms of the quality of the obtained solution. The computational experiments, performed on instances of benchmarking for the HFVRP, showed the efficiency and effectiveness of implementing some neighborhoods in metaheuristic algorithms of path, such as the Tabu Search.

Abstract
AbstractTranscriptional dysregulation is a key feature of cancer. Transcription factors (TFs) are the main link between signalling pathways and the transcriptional regulatory machinery of the cell, positioning them as key oncogenic inductors and therefore potential targets of therapeutic intervention. We implemented a computational pipeline to infer TF regulatory activities from basal gene expression and applied it to publicly available and newly generated RNA-seq data from a collection of 1,010 cancer cell lines and 9,250 primary tumors. We show that the predicted TF activities recapitulate known mechanisms of transcriptional dysregulation in cancer and dissect mutant-specific effects in driver genes. Importantly, we show the potential for predicted TF activities to be used as markers of sensitivity to the inhibition of their upstream regulators. Furthermore, combining these inferred activities with existing pharmacogenomic markers significantly improves the stratification of sensitive and resistant cell lines for several compounds. Our approach provides a framework to link driver genomic alterations with transcriptional dysregulation that helps to predict drug sensitivity in cancer and to dissect its mechanistic determinants.

Abstract
In this work we develop a theoretical model to describe the propagation of an optical pulse in a 4-level atomic system. We investigate the existence of dissipative soliton solutions and analyze the stability of these solitary waves, comparing the analytical results with computational simulations based on the effective (1+1)-dimensional model derived from the Maxwell-Bloch equation under the slowly-varying envelope approximation.