Abstract
Simple statistical models were developed to relate available meteorological data with daily river discharge (RD) for rivers not influenced by melting of ice and snow. In a case study of the Vouga River (Portugal), the RD could be determined by a linear combination of the recent (P (R)) and non-recent (P (NR)) atmospheric precipitation history. It was found that a simple linear model including only P (R) and P (NR) cannot account for low RD. The model was improved by including non-linear terms of precipitation that accounted for the water loss. Additional improvement of the models was possible by including average monthly air temperature (T). The best model was robust when up to 60% of the original data were randomly removed. The advantage is the simplicity of the models, which take into account only P (R), P (NR) and T. These models can provide a useful tool for RD estimation from current meteorological data.

Abstract
This paper presents the work performed in the implementation of an underwater simulation environment for the development of an autonomous underwater vehicle for the exploration of flooded underground tunnels. In particular, the implementation of a laser based structured light system, multibeam sonar and other robot details were addressed. The simulation was used as a relevant tool in order to study and specify the robot multiple sensors characteristics and placement in order to adequately survey a realistic environment. A detailed description of the research and development work is presented along with the analysis of obtained results and the benefits this work brings to the project.

Abstract
AbstractParkin and PINK1 function in a common pathway to clear damaged mitochondria. Parkin exists in an auto-inhibited conformation stabilized by multiple interdomain interactions. The binding of PINK1-generated phospho-ubiquitin and the phosphorylation of the ubiquitin-like (Ubl) domain of Parkin at Ser65 release its auto-inhibition, but how and when these events take place in cells remain to be defined. Here we show that mutations that we designed to activate Parkin by releasing the Repressor Element of Parkin (REP) domain, or by disrupting the interface between the RING0:RING2 domains, can completely rescue mutations in the Parkin Ubl that are defective in mitochondrial autophagy. Using a FRET reporter assay we show that Parkin undergoes a conformational change upon phosphorylation that can be mimicked by mutating Trp403 in the REP. We propose a hierarchical model whereby pUb binding on mitochondria enables Parkin phosphorylation, which, in turn, leads to REP removal, E3 ligase activation and mitophagy.

Abstract
Nowadays, the prevalence of computing systems in our lives is so ubiquitous that it would not be far-fetched to state that we live in a cyber-physical world dominated by computer systems. These systems demand for more and more computational performance to process large amounts of data from multiple data sources, some of them with guaranteed processing response times. In other words, systems are required to deliver their results within pre-defined (and sometimes extremely short) time bounds. Examples can be found for instance in intelligent transportation systems for fuel consumption reduction in cities or railway, or autonomous driving of vehicles. To cope with such performance requirements, chip designers produced chips with dozens or hundreds of cores, interconnected with complex networks on chip. Unfortunately, the parallelization of the computing activities brings many challenges, among which how to provide timing guarantees, as the timing behaviour of the system running within a many-core processor depends on interactions on shared resources that are most of the time not know by the system designer. P-SOCRATES (Parallel Software Framework for Time-Critical Many-core Systems) is an FP7 European project, which developed a novel methodology to facilitate the deployment of standardized parallel architectures for real-time applications. This methodology was implemented (based on existent models and components) to provide an integrated software development kit, the UpScale SDK, to fully exploit the huge performance opportunities brought by the most advanced many-core processors, whilst ensuring a predictable performance and maintaining (or even reducing) development costs of applications. The presentation will provide an overview of the UpScale SDK, its underlying methodology, and the results of its application on relevant industrial use-cases.

Abstract
This research aims to explore the importance of tourism activities for student mobility, considering the decision process, the experience of the students while on mobility, and their loyalty to the host region, including their cooperation in promoting local attractions among relatives and friends. We present qualitative results obtained from focus groups with Erasmus students from diverse countries inside and outside Europe, who spent at least one semester in the University of Aveiro, Portugal. The discussions explored students' perceptions, experiences and practices before and during the mobility. Our results include evidence on how traveling opportunities are an inherent part of Erasmus students' mobility. Overall, their tourist activities are shown as strong enhancers of the learning process while on mobility, despite competing with limited resources of time and money. Traveling is also an opportunity to spend time with family and friends, namely with other mobility students at the same host university, fostering integration and a higher degree of satisfaction with the mobility experience. In turn, the extended exposure to a different language and culture transform mobility students into ideal ambassadors of the host country, contributing significantly to the promotion of their mobility destinations.

Abstract
The multi-facility layout problem involves the physical organization of departments inside several facilities, to allow flexible and efficient operations. This work studies the facility layout problem in a new perspective, considering a group of facilities, and two different concerns: the location of departments within a group of facilities, and the location of departments inside each facility itself. The problem is formulated as a Quadratic Programming Problem with multiple objectives and unequal areas, allowing layout reconfigurations in each planning period. The objectives of the model are: the minimization of costs (material handling inside facilities and between facilities, and re-layout); the maximization of adjacency between departments; and the minimization of the "unsuitability" of department positions and locations. This unsuitability measure is a new objective proposed in this work, to combine the characteristics of existing locations with the requirements of departments. The model was tested with data from the literature as well as with a problem inspired in a first tier supplier in the automotive industry. Preliminary results show that this work can be viewed as an innovative and promising integrated approach for tackling real, complex facility layout problems.