Abstract
Health is one of the most fundamental human rights. In that sense, the creation of health systems attempted to provide the population with organisations, institutions, and resources to meet their needs. However, health inequalities are prevalent in all countries. Thus, evaluating health systems is vital to understand this issue. Accordingly, the aim of this work is to develop a multi-criteria decision analysis (MCDA) approach to innovatively rank nine of the European health systems with Beveridgian financing that would help determine the shortcomings of the Portuguese National Health Service and discern the operating "best practices", in a close interaction with the Portuguese Ministry of Health. First, the panel of decision-making actors was guided through the design of a cognitive map to promote their learning process and help them identify eleven fundamental points of view. Second, their operationalisation was facilitated by selecting acceptable descriptors of performance. Finally, an MCDA approach was proposed to evaluate the chosen health systems using an additive model, which included a sensitivity and a robustness analysis. In the end, the model was perceived by the panel as being trustworthy and reliable. This framework can be used for further MCDA modelling in similar applications based on participatory procedures.

Abstract
In clinical practice and in particular in the diagnostic process, the assessment of cardiac and respiratory functions is supported by electrocardiogram and auscultation. These exams are non-invasive, quick and inexpensive to perform and easy to interpret. For these reasons, this type of assessment is a constant in the daily life of a clinician and the information obtained is central to the decision making process. Therefore, it is essential that during their training, students of health-related subjects acquire skills in the acquisition and evaluation of the referred physiological signals. Simulation, considering the technological possibilities of today, is an excellent preparation tool since it exposes trainees to near real contexts but without the associated risks. Hence, the simulation of physiological signals plays an important role in the education of healthcare professionals, bioengineering professionals and also in the development and calibration of medical devices. This paper describes a project to develop synchronized electrocardiogram (ECG), phonocardiogram (PCG) and breathing sounds simulators that aims to improve an existing phantom simulator. The developed system allows, in an integrated way, to generate normal and pathological signals, being contemplated several distinct pathologies. For engineering education, it is also possible to simulate the introduction of signal disturbances or hardware malfunctions. A graphical interface allows changing operating parameters in real time.

Abstract

Abstract
Sign Language Recognition (SLR) has become an appealing topic in modern societies because such technology can ideally be used to bridge the gap between deaf and hearing people. Although important steps have been made towards the development of real-world SLR systems, signer-independent SLR is still one of the bottleneck problems of this research field. In this regard, we propose a deep neural network along with an adversarial training objective, specifically designed to address the signer-independent problem. Concretely speaking, the proposed model consists of an encoder, mapping from input images to latent representations, and two classifiers operating on these underlying representations: (i) the signclassifier, for predicting the class/sign labels, and (ii) the signer-classifier, for predicting their signer identities. During the learning stage, the encoder is simultaneously trained to help the sign-classifier as much as possible while trying to fool the signer-classifier. This adversarial training procedure allows learning signer-invariant latent representations that are in fact highly discriminative for sign recognition. Experimental results demonstrate the effectiveness of the proposed model and its capability of dealing with the large inter-signer variations.

Abstract
This paper presents an active fault diagnosis (AFD) method with reduced excitation for detection and identification of sensor faults of vehicles in a platoon formation. By introducing a probing signal into the platooning, it will allow an active excitation of the system, reveling a residual component, with the same frequency, that can be explored to obtain a fault identification of specific system faults. A supervisor is introduced to monitor the platoon behavior and activate the auxiliary input whenever the system natural excitation is insufficient for a clear fault diagnosis. This solution will allow the fault diagnosis to behave as active or passive through the adaptive signal provided by the supervisor. A dual Youla-Jabr-Bongiorno-Kucera (YJBK) matrix transfer function, also known as fault signature matrix (FSM) is investigated to get a fault diagnosis. In order to obtain an online identification of specific faults in the system, a Taylor approximation of the FSM is pursued. Computational simulations with a high-fidelity full-vehicle model, provided by CarSim, are carried out to demonstrate the effectiveness of the proposed active approach. A direct comparison between an active and a passive behavior in the same scenario shows that the active fault diagnosis method outperforms the passive approach whenever the dynamic behavior does not provide sufficient excitation. Furthermore, the excitation supervisor is able to significantly reduce the amount of artificial excitation introduced into the system ensuring a more energy efficient active fault diagnosis.

Abstract
Gastric Cancer (GC) is one of the most common and deadliest types of cancer in the world. To improve GC prognosis, increasing efforts are being made to develop new targeted therapies. Although FGFR2 genetic amplification and protein overexpression in GC have been targeted in clinical trials, so far no improvement in patient overall survival has been found. To address this issue, we studied genetic and epigenetic events affecting FGFR2 and its splicing regulator ESRP1 in GC that could be used as new therapeutic targets or predictive biomarkers. We performed copy number variation (CNV), DNA methylation, and RNA expression analyses of FGFR2/ESRP1 across several cohorts. We discovered that both genes were frequently amplified and demethylated in GC, resulting in increased ESRP1 expression and of a specific FGFR2 isoform: FGFR2-IIIb. We also showed that ESRP1 amplification in GC correlated with a significant decreased expression of FGFR2-IIIc, an alternative FGFR2 splicing isoform. Furthermore, when we performed a survival analysis, we observed that patients harboring diffuse-type tumors with low FGFR2-IIIc expression revealed a better overall survival than patients with FGFR2-IIIc high-expressing diffuse tumors. Our results encourage further studies on the role of ESRP1 in GC and support FGFR2-IIIc as a relevant biomarker in GC.