Abstract
This article presents a solution for a work related to the curricular unit Energy Markets and Regulation within the scope of PDEEC-Doctoral Program in Electrical and Computer Engineering. The task consists of evaluating optimal dispatch and market pool results (symmetric and asymmetric) for different periods. To check the technical feasibility of implementing the dispatch recommended by the pool market, a DC power flow is analyzed, by accounting for a network with six busbars. Results show that in some periods of higher demand, there could be an overload in some transmission lines of the considered network for certain results of market dispatch. © 2024, Universidade do Porto - Faculdade de Engenharia. All rights reserved.

Abstract
Methylation is considered one of the proteins' most important post-translational modifications (PTM). Plasticity and cellular dynamics are among the many traits that are regulated by methylation. Currently, methylation sites are identified using experimental approaches. However, these methods are time-consuming and expensive. With the use of computer modelling, methylation sites can be identified quickly and accurately, providing valuable information for further trial and investigation. In this study, we propose a new machine-learning model called MeSEP to predict methylation sites that incorporates both evolutionary and structural-based information. To build this model, we first extract evolutionary and structural features from the PSSM and SPD2 profiles, respectively. We then employ Extreme Gradient Boosting (XGBoost) as the classification model to predict methylation sites. To address the issue of imbalanced data and bias towards negative samples, we use the SMOTETomek-based hybrid sampling method. The MeSEP was validated on an independent test set (ITS) and 10-fold cross-validation (TCV) using lysine methylation sites. The method achieved: an accuracy of 82.9% in ITS and 84.6% in TCV; precision of 0.92 in ITS and 0.94 in TCV; area under the curve values of 0.90 in ITS and 0.92 in TCV; F1 score of 0.81 in ITS and 0.83 in TCV; and MCC of 0.67 in ITS and 0.70 in TCV. MeSEP significantly outperformed previous studies found in the literature. MeSEP as a standalone toolkit and all its source codes are publicly available at https://github.com/arafatro/MeSEP.

Abstract
In 2021, the energy sector was put at risk by extreme weather in many different ways: North America and Spain suffered heavy winter storms that led to the collapse of the electricity network; California speci fi cally experienced heavy droughts and heat -wave conditions, causing the operations of hydropower stations to halt; fl oods caused substantial damage to energy infrastructure in central Europe, Australia, and China throughout the year, and unusual wind drought conditions decreased wind power production in the United Kingdom by almost 40% during summer. The total economic impacts of these extreme weather events are estimated at billions of U.S. dollars. Here we review and assess in some detail the main extreme weather events that impacted the energy sector in 2021 worldwide, discussing some of the most relevant case studies and the meteorological conditions that led to them. We provide a perspective on their impacts on electricity generation, transmission, and consumption, and summarize estimations of economic losses.

Abstract

Abstract
Proactive participation of uncertain renewable generation in the day-ahead (DA) wholesale market effectively reduces the system marginal price and carbon emissions, whilst significantly increasing the volumes of real-time balancing mechanism prices to ensure system security and stability. To solve the conflicting interests over the two timescales, this article: 1) proposes a novel hierarchical optimization model to align with the actual operation paradigms of the hierarchical market, whereby the capacity allocation matrix is adopted to coordinate the DA and balancing markets; 2) mathematically formulates and quantitatively analyses the long-term driving factors of balancing actions, enabling system operators (SOs) to design efficient and well-functioning market structures to meet economic and environmental targets; 3) empowers renewable generating units and flexible loads to participate in the balancing market (BM) as 'active' actors and enforces the non-discriminatory provision of balancing services. The performance of the proposed model is validated on a modified IEEE 39-bus power system and a reduced GB network. Results reveal that with effective resource allocation in different timescales of the hierarchical market, the drop speed of balancing costs soars while the intermittent generation climbs. The proposed methodology enables SOs to make the most of all resources available in the market and balance the system flexibly and economically. It thus safeguards the climate mitigation pathways against the risks of substantially higher balancing costs.

Abstract
In an era characterized by extensive use of and reliance on information and communications technology (ICT), cyber-physical power systems (CPPSs) have emerged as a critical integral of modern power infrastructures, providing vital energy sources to consumers, communities, and industries worldwide. The integration of ICT in these systems, while beneficial, introduces a rapidly evolving range of cybersecurity challenges that significantly threaten their confidentiality, integrity, and availability. To address this, our article offers a comprehensive and timely survey of the current landscape of cyber vulnerabilities in CPPS, reflecting the latest developments in the field up to the present. This includes an in-depth analysis of the diverse types of cyber threats to CPPS and their potential consequences, underscoring the necessity for a broad, multidisciplinary approach. Our review is distinguished by its thoroughness and timeliness, covering recent research to offer one of the most current overviews of cybersecurity in CPPSs. We adopt a holistic perspective, integrating technical, societal, environmental, and policy implications, thereby providing a more comprehensive understanding of cybersecurity in CPPSs. We delve into the complexities of cyberattacks, exploring sophisticated, targeted attacks alongside common threats, and emphasize the dynamic nature of cyber threats, providing insights into their evolution and future trends. Additionally, our review highlights critical yet often overlooked challenges, such as system visibility and standardization in security protocols, arguing their significance in enhancing CPPS resilience. Furthermore, our work gives special attention to the aspects of restoration and recovery postcyberattack, an area less emphasized in the existing literature. Through this comprehensive overview of the current state and evolving challenges of CPPS security, our article serves as an indispensable resource for research, practice, and policymaking dedicated to safeguarding the safety, reliability, and resilience of ICT-empowered energy systems.