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Detalhes

Detalhes

  • Nome

    Bruna Costa Tavares
  • Cluster

    Energia
  • Cargo

    Investigador
  • Desde

    01 outubro 2015
002
Publicações

2022

Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation

Autores
Laranjo, M; Pereira, NAM; Oliveira, ASR; Aguiar, MC; Brites, G; Nascimento, BFO; Serambeque, B; Costa, BDP; Pina, J; de Melo, JSS; Pineiro, M; Botelho, MF; Melo, TMVDPE;

Publicação
FRONTIERS IN CHEMISTRY

Abstract
Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosensitizers' performance, considering the singlet oxygen generation data, cell internalization, and intracellular localization, allowed to establish relevant structure-photoactivity relationships and the rationalization of the observed photocytotoxicity. In the diacid and monoalcohol series, chlorins derived from meso-tetraphenylporphyrin proved to be the most efficient photodynamic therapy agents, showing IC50 values of 68 and 344 nM against A375 cells, respectively. These compounds were less active against OE19 and HT1376 cells, the diacid chlorin with IC50 values still in the nano-molar range, whereas the monohydroxymethyl-chlorin showed significantly higher IC50 values. The lead di(hydroxymethyl)-substituted meso-tetraphenylchlorin confirmed its remarkable photoactivity with IC50 values below 75 nM against the studied cancer cell lines. Subcellular accumulation of this chlorin in the mitochondria, endoplasmic reticulum, and plasma membrane was demonstrated.

2020

An innovative approach for distribution network reinforcement planning: Using DER flexibility to minimize investment under uncertainty

Autores
Tavares, B; Soares, FJ;

Publicação
ELECTRIC POWER SYSTEMS RESEARCH

Abstract

2018

Electric Vehicles Charging: Management and Control Strategies

Autores
Soares, FJ; Rua, D; Gouveia, C; Tavares, BD; Coelho, AM; Lopes, JAP;

Publicação
IEEE VEHICULAR TECHNOLOGY MAGAZINE

Abstract
In this article, we present a holistic framework for the integration of electric vehicles (EVs) in electric power systems. Their charging management and control methodologies must be optimized to minimize the negative impact of the charging process on the grid and maximize the benefits that charging controllability may bring to their owners, energy retailers, and system operators. We have assessed the performance of these methods initially through steady-state computational simulations, and then we validated them in a microgrid (MG) laboratory environment. © 2018 IEEE.

2018

Distribution Network Planning Using Detailed Flexibility Models for DER

Autores
Tavares, B; Soares, F;

Publicação
IET Conference Publications

Abstract

2017

Assessing the Impact of Demand Flexibility on Distribution Network Operation

Autores
Tavares, BD; Sumaili, J; Soares, FJ; Madureira, AG; Ferreira, R;

Publicação
2017 IEEE MANCHESTER POWERTECH

Abstract
This paper presents a study about the influence of Distributed Energy Resources' (DER) flexibility on the operation of a Medium Voltage (MV) network, in a Smart Grid (SG) environment. An AC multi-temporal Optimal Power Flow (OPF) tool was developed and used to simulate the impact of the DER flexibility (including storage devices, EVs, controllable loads and micro-generation) in distribution network operation. Some simulations are presented, demonstrating the impact that DER flexibility can have on solving operation problems namely in terms of branch loading and voltage limits.