Detalhes
Nome
Bruna Costa TavaresCluster
EnergiaCargo
InvestigadorDesde
01 outubro 2015
Nacionalidade
PortugalCentro
Centro de Sistemas de EnergiaContactos
+351222094230
bruna.c.tavares@inesctec.pt
2022
Autores
Laranjo, M; Pereira, NAM; Oliveira, ASR; Aguiar, MC; Brites, G; Nascimento, BFO; Serambeque, B; Costa, BDP; Pina, J; de Melo, JSS; Pineiro, M; Botelho, MF; Melo, TMVDPE;
Publicação
FRONTIERS IN CHEMISTRY
Abstract
Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosensitizers' performance, considering the singlet oxygen generation data, cell internalization, and intracellular localization, allowed to establish relevant structure-photoactivity relationships and the rationalization of the observed photocytotoxicity. In the diacid and monoalcohol series, chlorins derived from meso-tetraphenylporphyrin proved to be the most efficient photodynamic therapy agents, showing IC50 values of 68 and 344 nM against A375 cells, respectively. These compounds were less active against OE19 and HT1376 cells, the diacid chlorin with IC50 values still in the nano-molar range, whereas the monohydroxymethyl-chlorin showed significantly higher IC50 values. The lead di(hydroxymethyl)-substituted meso-tetraphenylchlorin confirmed its remarkable photoactivity with IC50 values below 75 nM against the studied cancer cell lines. Subcellular accumulation of this chlorin in the mitochondria, endoplasmic reticulum, and plasma membrane was demonstrated.
2020
Autores
Tavares, B; Soares, FJ;
Publicação
ELECTRIC POWER SYSTEMS RESEARCH
Abstract
2018
Autores
Soares, FJ; Rua, D; Gouveia, C; Tavares, BD; Coelho, AM; Lopes, JAP;
Publicação
IEEE VEHICULAR TECHNOLOGY MAGAZINE
Abstract
In this article, we present a holistic framework for the integration of electric vehicles (EVs) in electric power systems. Their charging management and control methodologies must be optimized to minimize the negative impact of the charging process on the grid and maximize the benefits that charging controllability may bring to their owners, energy retailers, and system operators. We have assessed the performance of these methods initially through steady-state computational simulations, and then we validated them in a microgrid (MG) laboratory environment. © 2018 IEEE.
2018
Autores
Tavares, B; Soares, F;
Publicação
IET Conference Publications
Abstract
2017
Autores
Tavares, BD; Sumaili, J; Soares, FJ; Madureira, AG; Ferreira, R;
Publicação
2017 IEEE MANCHESTER POWERTECH
Abstract
This paper presents a study about the influence of Distributed Energy Resources' (DER) flexibility on the operation of a Medium Voltage (MV) network, in a Smart Grid (SG) environment. An AC multi-temporal Optimal Power Flow (OPF) tool was developed and used to simulate the impact of the DER flexibility (including storage devices, EVs, controllable loads and micro-generation) in distribution network operation. Some simulations are presented, demonstrating the impact that DER flexibility can have on solving operation problems namely in terms of branch loading and voltage limits.
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