Abstract
Mean sea level is a variable of considerable interest in meteorological and oceanographic studies, particularly long-term sea level variation and its relation to climate changes. This study concerns the analysis of monthly mean sea level data from tide gauge stations in the Northeast Atlantic with long and continuous records. Much research effort on mean sea level studies has been focused on identifying long-term linear trends, usually estimated through least-squares fitting of a deterministic function. Here, we estimate nonparametric and robust trends using lowess, a robust smoothing procedure based on locally weighted regression. This approach is more flexible than a linear trend to describe the deterministic part of the variation in tide gauge records, which has a complex structure. A common trend pattern of reduced sea levels around 1975 is found in all the analysed records and interpreted as the result of hydrological and atmospheric forcing associated with drought conditions at the tide gauge sites. This feature is overlooked by a linear regression model. Moreover, nonlinear deterministic behaviour in the time series, such as the one identified, introduces a bias in linear trends determined from short and noisy records.

Abstract
Spatial and temporal sea level variability in the North Atlantic is investigated from Topex/Poseidon (T/P) altimetry data. Time series of sea level anomalies on a regular 5 degrees grid are analysed. Non-linear denoising through thresholding in the wavelet transform domain is carried out for each series in order to remove noise while preserving non-smooth features. Principal Component Analysis (PCA) is used to obtain a spatio-temporal description of the sea level field, To avoid modal mixing and improve interpretation of the principal modes, PCA is implemented separately for seasonal and trend components of the sea level field obtained from a wavelet-based multiresolution analysis. The leading pattern of the seasonal field reflects the dominance of a stable annual cycle over the study area and the change in the seasonal regime approaching the equator with contribution of the semi-annual cycle and phase-shift in the annual cycle in the tropical Atlantic. The leading pattern of the trend field is a broad spatial pattern associated with North Atlantic Oscillation (NAO), reflecting the influence of atmospheric conditions on interannual sea level variability.

Abstract
Long-term heart rate variability (HRV) series can be described by time-variant autoregressive modelling. HRV recordings show dependence between distant observations that is not negligible, suggesting the existence of long-range correlations. In this work, selective adaptive segmentation combined with fractionally integrated autoregressive moving-average models is used to capture long memory in HRV recordings. This approach leads to an improved description of the low- and high-frequency components in HRV spectral analysis. Moreover, it is found that in the 24-h recording of a case report, the long-memory parameter presents a circadian variation, with different regimes for day and night periods.

Abstract
Heart rate variability (HRV) data display non-stationary characteristics and exhibit long-range correlation (memory). Detrended fluctuation analysis (DFA) has become a widely-used technique for long memory estimation in non-stationary HRV data. Recently, we have proposed an alternative approach based on fractional integrated autoregressive moving average (ARFIMA) models. ARFIMA models, combined with selective adaptive segmentation may be used to capture and remove long-range correlation, leading to an improved description and interpretation of tire components in 24 hour HRV recordings. In this work estimation of long memory by DFA and selective adaptive ARFIMA modelling is carried out in 24 hour HRV recordings of 17 healthy subjects of two age groups. The two methods give similar information on long-range global characteristics. However ARFIMA modelling is advantageous, allowing the description of long-range correlation in reduced length segments.

Abstract
Heart rate variability (HRV) data display nonstationary characteristics, exhibit long-range correlations (memory) and instantaneous variability (volatility). Recently, we have proposed fractionally integrated autoregressive moving average (ARFIMA) models for a parametric alternative to the widely-used technique detrended fluctuation analysis, for long memory estimation in HRV. Usually, the volatility in HRV studies is assessed by recursive least squares. In this work, we propose an alternative approach based on ARFIMA models with generalized autoregressive conditionally heteroscedastic (GARCH) innovations. ARFIMA-GARCH models, combined with selective adaptive segmentation, may be used to capture and remove long-range correlation and estimate the conditional volatility in 24 hour HRV recordings. The ARFIMA-GARCH approach is applied to 24 hour HRV recordings from the Noltisalis database allowing to discriminate between the different groups.

Abstract
In the last decades propofol became established as an intravenous agent for the induction and maintenance of both sedation and general anesthesia procedures. In order to achieve the desired clinical effects appropriate infusion rate strategies must be designed. Moreover, it is important to avoid or minimize side effects which may be associated with adverse cardiorespiratory effects and delayed recovery. Nowadays, to attain these purposes the continuous propofol delivery is usually performed through target-controlled infusion (TCI) systems whose algorithms rely on pharmacokinetic and pharmacodynamic models (Schraag, 2001). This work presents statistical models to estimate both the infusion rate and the bolus administration. The modeling strategy relies on multivariate linear models for panel data (Wooldridge, 2002), based on patient characteristics such as age, height, weight and gender along with the desired target concentration. A clinical database collected with a RugLoopII device on 84 patients undergoing ultrasonographic endoscopy under sedation-analgesia with propofol and remifentanil, (Gambús et al., 2011), is used to estimate the models (training set with 74 cases) and assess their performance (test set with 10 cases). The results obtained in the test set comprising a broad range of characteristics are satisfactory since the models are able to predict bolus and infusion rates comparable to those of TCI. © 2012 IFAC.