Abstract
Advancements in the care for patients with breast cancer have demanded the development of biomechanical breast models for the planning and risk mitigation of such invasive surgical procedures. However, these approaches require large amounts of high-quality magnetic resonance imaging (MRI) training data that is of difficult acquisition and availability. Although this can be solved using synthetic data, generating high resolution images comes at the price of very high computational constraints and tipically low performances. On the other hand, producing lower resolution samples yields better results and efficiency but falls short of meeting health professional standards. Therefore, this work aims to validate a joint approach between lower resolution generative models and the proposed super-resolution architecture, titled Shifted Window Image Restoration (SWinIR), which was used to achieve a 4x increase in image size of breast cancer patient MRI samples. Results prove to be promising and to further expand upon the super-resolution state-of-the-art, achieving good maximum peak signal-to-noise ratio of 41.36 and structural similarity index values of 0.962 and thus beating traditional methods and other machine learning architectures.

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Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction relies on the precise identification of perforator vessels supplying blood to transferred tissue. Traditional manual mapping from preoperative imaging is timeconsuming and subjective. To address this, AVA, a semi-automated perforator detection algorithm, was developed to analyze angiography images. AVA follows a three-step process: automated anatomical segmentation, manual annotation of perforators, and segmentation of perforator courses. This approach enhances accuracy, reduces subjectivity, and accelerates the mapping process while generating quantitative reports for surgical planning. To streamline integration into clinical workflows, AVA has been embedded into PACScenter, a medical imaging platform, leveraging DICOM encapsulation for seamless data exchange within a Vendor Neutral Archive (VNA). This integration allows surgeons to interactively annotate perforators, adjust parameters iteratively, and visualize detailed anatomical structures. AVA-PACScenter integration eliminates workflow disruptions by providing real-time perforator analysis within the surgical environment, ultimately improving preoperative planning and intraoperative guidance. Currently undergoing clinical feasibility testing, this integration aims to enhance DIEP flap reconstruction efficiency by reducing manual inputs, improving mapping precision, and facilitating long-term report storage within Dicoogle. By automating perforator analysis, AVA represents a significant advancement toward data-driven, patient-centered surgical planning.

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Lung cancer remains one of the most common and lethal forms of cancer, with approximately 1.8 million deaths annually, often diagnosed at advanced stages. Early detection is crucial, but it depends on physicians' accurate interpretation of computed tomography (CT) scans, a process susceptible to human limitations and variability. ByMe has developed a medical image annotation and anonymization tool designed to address these challenges through a human-centered approach. The tool enables physicians to seamlessly add structured attribute-based annotations (e.g., size, location, morphology) directly within their established workflows, ensuring intuitive interaction.Integrated with Picture Archiving and Communication Systems (PACS), the tool streamlines the annotation process and enhances usability by offering a dedicated worklist for retrospective and prospective case analysis. Robust anonymization features ensure compliance with privacy regulations such as the General Data Protection Regulation (GDPR), enabling secure dataset sharing for research and developing artificial intelligence (AI) models. Designed to empower AI integration, the tool not only facilitates the creation of high-quality datasets but also lays the foundation for incorporating AI-driven insights directly into clinical workflows. Focusing on usability, workflow integration, and privacy, this innovation bridges the gap between precision medicine and advanced technology. By providing the means to develop and train AI models for lung cancer detection, it holds the potential to significantly accelerate diagnosis as well as enhance its accuracy and consistency.

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