Abstract
The industry faces more and more the challenge of deploying and taking advantage of evidence-based strategic decisions to enhance profit gain. In this research, the possibility of having a fully integrated system composed by a simulator and an IoT platform with the capability of collecting real-time data from the shop floor and returning performance indicators to support decision making is evaluated. The suggested approach involves a Manufacturing Executing System (MES) producing a production schedule, an IoT Platform composed by a message broker and a real-time database, a Simulator including simulation software and a wrapper, and a user application serving as an interface between the user and the IoT Platform and Simulator integrated system. A detailed analysis of the functionalities and integration of the Simulator and the IoT Platform will also be explored. To evaluate the approach, one use case of a production line in the automotive industry is used. The application of the integrated IoT Simulation system permits its validation and consequent future work. © 2019, IEOM Society International.

Abstract
The principles and tools made available by the Industry 4.0, smart factories, or the Internet of Things (IoT), along with the adoption of more comprehensive simulation models, can significantly help the industry to face the current, huge external and internal challenges. This paper presents a new simulation-based approach to support decision making in the design and operational management of manufacturing systems. This approach is used to evaluate different layouts and resources allocation, and help managing operations, by integrating a simulation software with real-time data collected from the production assets through an IoT platform. The developed methodology uses a digital representation of the real production system (that may be viewed as a form of a digital twin) to assess different production scenarios. A set of key performance indicators (e.g. productivity) provided by the simulation can be used by the Manufacturing Execution System (MES) to generate production schedules. The developed approach was implemented and assessed in a real case study, showing its robustness and application potential. Its extension to other industrial contexts and sectors seems, therefore, quite promising. Copyright (C) 2021 The Authors.

Abstract
Industry 4.0 is transforming manufacturing environments, with robotics being a key technology that enhances various capabilities. The flexibility of Autonomous Mobile Robots has led to the rise of multi-robot systems in industrial settings. Considering the high cost of these robots, it is essential to determine the best fit of number and type before making any major investments. Simulation and modeling are valuable decision-support tools, allowing the simulation of different setups to address robot fleet sizing issues. This paper introduces a decision-support framework that combines a fleet manager software stack with the FlexSim simulator, helping decision-makers determine the most suitable mobile robots fleet size tailored to their needs. Unlike previous approaches, the developed solution integrates the same real robot coordination software in both simulation and actual deployment, ensuring that tested scenarios accurately reflect real-world conditions. A case study was conducted to evaluate the framework, involving multiple tasks of loading and unloading materials within a warehouse. Five different scenarios with varying fleet sizes were simulated, and their performances assessed. The analysis concluded that, for the case study under consideration, a fleet of three robots was the most suitable, considering relevant key performance indicators. The results confirmed that the developed solution is an effective alternative for addressing the problem and represents a novel technology with no prior state-of-the-art equivalents.

Abstract
Warehouses and distribution centres play a key role in any Supply Chain, particularly in the retail sector, where a network of stores needs to be replenished in a highly dynamic and increasingly uncertain context. In this regard, companies need to improve their intralogistics systems daily to ensure long-term competitiveness and sustainable growth. This is especially true in picking-by-line systems where many time-consuming and manual tasks are usually involved. This study introduces a new decision support tool based on simulation methods to aid the decision-making process in a picking-by-Line system, aimed to improve the overall picking operations efficiency, through human-centric perspective. A Discrete-Event-Simulation model is proposed to assess a set of parameters under several scenarios, driving a more informed decision-making process towards cost-effective strategies. The proposed approach was validated through an empirical case study showing its effectiveness in assisting operational planning decisions related to capacity and resource allocation. The system demonstrates promising versatility for application across varied warehouse environments. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

Abstract
In the dynamic realm of nowadays manufacturing, integrating digital technologies has become paramount for enhancing operational efficiency and decision-making processes. This article presents a novel system architecture that integrates a Simulation-based Digital Twin (DT) with emerging trends in manufacturing to enhance decision-making, accompanied by a detailed technical approach encompassing protocols and technologies for each component. The DT leverages advanced simulation techniques to model, monitor, and optimize production processes in real time, facilitating both strategic and operational decision-making. Complementing the DT, trending technologies such as artificial intelligence, additive manufacturing, collaborative robots, autonomous vehicles, and connectivity advancements are strategically integrated to enhance operational efficiency and facilitate the adoption of the Manufacturing as a Service (MaaS) paradigm. A case study within a MaaS supplier context, deployed in an industrial laboratory with advanced robotic systems, demonstrates the practical application of optimizing dynamic job-shop configurations using Simulation-based DT, showcasing strategies to improve operational efficiency and resource utilization. The results of the industrial experiment were highly encouraging, underscoring the potential for extension to more intricate industrial systems, with particular emphasis on incorporating sustainability and remanufacturing principles.

Abstract
A new generation of manufacturing systems is emerging through the adoption of new policies to overcome future crises highlighted by constant social, environmental, and economic concerns. The rise of so-called smart manufacturing is noticeable. However, new risks to humankind are being introduced, and, more than ever, science and technology are required to guarantee the future sustainability and resilience of our manufacturing systems. This research presents a Digital Twin approach resorting to simulation models with embedded intelligence to transform efficient manufacturing systems and react to complex and unpredictable circumstances. The methodology covers production scheduling incorporating flexible robots, internal logistics supervision contemplating planning and control of mobile robots, and capacity management. The method demonstrates the potential of integrating Additive Manufacturing technologies to quickly react to production needs. The developed strategy was enforced and assessed in an industrial experiment, exhibiting its robustness and promising application. The attained results were very encouraging, highlighting its potential extension to more complex industrial systems.